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P-105 Glycine attenuates impairments of interhemispheric gamma-band connectivity in the ketamine model of schizophrenia

Standard

P-105 Glycine attenuates impairments of interhemispheric gamma-band connectivity in the ketamine model of schizophrenia. / Curic, Stjepan; Haaf, Moritz; Steinmann, Saskia; Rauh, Jonas; Leicht, Gregor; Mulert, Christoph.

in: CLIN NEUROPHYSIOL, Jahrgang 148, e56, 04.2023.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › Konferenz-Abstract in Fachzeitschrift › Forschung

Harvard

Curic, S, Haaf, M, Steinmann, S, Rauh, J, Leicht, G & Mulert, C 2023, 'P-105 Glycine attenuates impairments of interhemispheric gamma-band connectivity in the ketamine model of schizophrenia', CLIN NEUROPHYSIOL, Jg. 148, e56. https://doi.org/10.1016/j.clinph.2023.02.122

APA

Curic, S., Haaf, M., Steinmann, S., Rauh, J., Leicht, G., & Mulert, C. (2023). P-105 Glycine attenuates impairments of interhemispheric gamma-band connectivity in the ketamine model of schizophrenia. CLIN NEUROPHYSIOL, 148, [e56]. https://doi.org/10.1016/j.clinph.2023.02.122

Vancouver

Curic S, Haaf M, Steinmann S, Rauh J, Leicht G, Mulert C. P-105 Glycine attenuates impairments of interhemispheric gamma-band connectivity in the ketamine model of schizophrenia. CLIN NEUROPHYSIOL. 2023 Apr;148. e56. https://doi.org/10.1016/j.clinph.2023.02.122

Bibtex

@article{37676afff8ba4b6b802f237ace76b632,
title = "P-105 Glycine attenuates impairments of interhemispheric gamma-band connectivity in the ketamine model of schizophrenia",
abstract = "Background: In patients with schizophrenia alterations in auditory perception are common. Disturbed N-methyl-D-aspartate receptor (NMDAR) functioning has been suggested as a possible mechanism causing Excitatory-to-inhibitory (E/I) imbalance, altered connectivity and changes in auditory perception in schizophrenia. The current study examined the effects of ketamine, a NMDAR antagonist as well as glycine, a glutamate N-Methyl-D-Aspartate receptor (NMDAR)-coagonist on mechanisms underlying interhemispheric gamma-band connectivity and conscious auditory perception during dichotic listening (DL).Methods: In a double-blind, randomized, placebo-controlled crossover design, 25 n healthy volunteers were measured using 64-channel-electroencephalography (EEG). Psychopathologic changes were assessed by PANSS and the subjective 5D-ASC questionnaire.Results: Interhemispheric connectivity analysis were performed using eLORETA source estimation and lagged phase synchronization (LPS) in the gamma-band range (30–100 Hz). Ketamine induced a schizophrenia-like change in laterality of dichotic hearing that could be reversed by glycine-modulation. In addition, interhemispheric gamma-band connectivity was found to be altered both under ketamine and glycine (higher interhemispheric gamma-band connectivity). Pretreatment with glycine normalized the ketamine-induced alterations of interhemispheric connectivity.Conclusion: These findings argue for an important role of glutamatergic neurotransmission for the interhemispheric communication between bilateral auditory cortices. NMDAR-modulation could help to restore E/I-imbalance causing disturbed auditory perception in schizophrenia.",
author = "Stjepan Curic and Moritz Haaf and Saskia Steinmann and Jonas Rauh and Gregor Leicht and Christoph Mulert",
year = "2023",
month = apr,
doi = "10.1016/j.clinph.2023.02.122",
language = "English",
volume = "148",
journal = "CLIN NEUROPHYSIOL",
issn = "1388-2457",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - P-105 Glycine attenuates impairments of interhemispheric gamma-band connectivity in the ketamine model of schizophrenia

AU - Curic, Stjepan

AU - Haaf, Moritz

AU - Steinmann, Saskia

AU - Rauh, Jonas

AU - Leicht, Gregor

AU - Mulert, Christoph

PY - 2023/4

Y1 - 2023/4

N2 - Background: In patients with schizophrenia alterations in auditory perception are common. Disturbed N-methyl-D-aspartate receptor (NMDAR) functioning has been suggested as a possible mechanism causing Excitatory-to-inhibitory (E/I) imbalance, altered connectivity and changes in auditory perception in schizophrenia. The current study examined the effects of ketamine, a NMDAR antagonist as well as glycine, a glutamate N-Methyl-D-Aspartate receptor (NMDAR)-coagonist on mechanisms underlying interhemispheric gamma-band connectivity and conscious auditory perception during dichotic listening (DL).Methods: In a double-blind, randomized, placebo-controlled crossover design, 25 n healthy volunteers were measured using 64-channel-electroencephalography (EEG). Psychopathologic changes were assessed by PANSS and the subjective 5D-ASC questionnaire.Results: Interhemispheric connectivity analysis were performed using eLORETA source estimation and lagged phase synchronization (LPS) in the gamma-band range (30–100 Hz). Ketamine induced a schizophrenia-like change in laterality of dichotic hearing that could be reversed by glycine-modulation. In addition, interhemispheric gamma-band connectivity was found to be altered both under ketamine and glycine (higher interhemispheric gamma-band connectivity). Pretreatment with glycine normalized the ketamine-induced alterations of interhemispheric connectivity.Conclusion: These findings argue for an important role of glutamatergic neurotransmission for the interhemispheric communication between bilateral auditory cortices. NMDAR-modulation could help to restore E/I-imbalance causing disturbed auditory perception in schizophrenia.

AB - Background: In patients with schizophrenia alterations in auditory perception are common. Disturbed N-methyl-D-aspartate receptor (NMDAR) functioning has been suggested as a possible mechanism causing Excitatory-to-inhibitory (E/I) imbalance, altered connectivity and changes in auditory perception in schizophrenia. The current study examined the effects of ketamine, a NMDAR antagonist as well as glycine, a glutamate N-Methyl-D-Aspartate receptor (NMDAR)-coagonist on mechanisms underlying interhemispheric gamma-band connectivity and conscious auditory perception during dichotic listening (DL).Methods: In a double-blind, randomized, placebo-controlled crossover design, 25 n healthy volunteers were measured using 64-channel-electroencephalography (EEG). Psychopathologic changes were assessed by PANSS and the subjective 5D-ASC questionnaire.Results: Interhemispheric connectivity analysis were performed using eLORETA source estimation and lagged phase synchronization (LPS) in the gamma-band range (30–100 Hz). Ketamine induced a schizophrenia-like change in laterality of dichotic hearing that could be reversed by glycine-modulation. In addition, interhemispheric gamma-band connectivity was found to be altered both under ketamine and glycine (higher interhemispheric gamma-band connectivity). Pretreatment with glycine normalized the ketamine-induced alterations of interhemispheric connectivity.Conclusion: These findings argue for an important role of glutamatergic neurotransmission for the interhemispheric communication between bilateral auditory cortices. NMDAR-modulation could help to restore E/I-imbalance causing disturbed auditory perception in schizophrenia.

U2 - 10.1016/j.clinph.2023.02.122

DO - 10.1016/j.clinph.2023.02.122

M3 - Conference abstract in journal

VL - 148

JO - CLIN NEUROPHYSIOL

JF - CLIN NEUROPHYSIOL

SN - 1388-2457

M1 - e56

ER -