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Overexpression of the chromatin remodeler death-domain-associated protein in prostate cancer is an independent predictor of early prostate-specific antigen recurrence

Standard

Overexpression of the chromatin remodeler death-domain-associated protein in prostate cancer is an independent predictor of early prostate-specific antigen recurrence. / Tsourlakis, Maria Christina; Schoop, Michael; Plaß, Christoph; Huland, Hartwig; Graefen, Markus; Steuber, Thomas; Schlomm, Thorsten; Simon, Ronald; Sauter, Guido; Sirma, Hüseyin; Minner, Sarah.

in: HUM PATHOL, Jahrgang 44, Nr. 9, 01.09.2013, S. 1789-96.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Tsourlakis, MC, Schoop, M, Plaß, C, Huland, H, Graefen, M, Steuber, T, Schlomm, T, Simon, R, Sauter, G, Sirma, H & Minner, S 2013, 'Overexpression of the chromatin remodeler death-domain-associated protein in prostate cancer is an independent predictor of early prostate-specific antigen recurrence', HUM PATHOL, Jg. 44, Nr. 9, S. 1789-96. https://doi.org/10.1016/j.humpath.2013.01.022

APA

Tsourlakis, M. C., Schoop, M., Plaß, C., Huland, H., Graefen, M., Steuber, T., Schlomm, T., Simon, R., Sauter, G., Sirma, H., & Minner, S. (2013). Overexpression of the chromatin remodeler death-domain-associated protein in prostate cancer is an independent predictor of early prostate-specific antigen recurrence. HUM PATHOL, 44(9), 1789-96. https://doi.org/10.1016/j.humpath.2013.01.022

Vancouver

Tsourlakis MC, Schoop M, Plaß C, Huland H, Graefen M, Steuber T et al. Overexpression of the chromatin remodeler death-domain-associated protein in prostate cancer is an independent predictor of early prostate-specific antigen recurrence. HUM PATHOL. 2013 Sep 1;44(9):1789-96. https://doi.org/10.1016/j.humpath.2013.01.022

Bibtex

@article{34ebaed8d88e457d85059a64b3e4660d,
title = "Overexpression of the chromatin remodeler death-domain-associated protein in prostate cancer is an independent predictor of early prostate-specific antigen recurrence",
abstract = "Molecular markers reliably predicting the aggressiveness of prostate cancer are currently lacking. Death-domain-associated protein (DAXX) has been implicated in the regulation of chromatin remodeling, transcription, and apoptosis that are integral to oncogenesis and cancer progression. DAXX expression was analyzed by immunohistochemistry on a tissue microarray containing 7478 prostate cancer specimens. Results were compared with tumor phenotype, biochemical recurrence, and v-ets erythroblastosis virus E26 oncogene homolog (ERG) status. DAXX expression was predominantly seen in the nucleus. DAXX expression was detectable in 4609 (80.6%) of 5718 interpretable cancers and considered strong in 5.9%, moderate in 45.8%, and weak in 28.9%. Strong DAXX expression was associated with both transmembrane protease, serine 2 (TMPRSS2)/ERG rearrangement and ERG expression (P < .0001 each). Strong DAXX expression was tightly linked to high Gleason grade, advanced pT stage, increased cell proliferation index, and early prostate-specific antigen recurrence (P < .0001 each). The prognostic role of DAXX expression was independent of Gleason grade, pT stage, and pN stage. Our study establishes DAXX as a novel independent prognosticator in prostate cancer and suggests an important role of DAXX expression for both prostate cancer development and progression. Furthermore, DAXX appears to exert biologically different effects in ERG-positive and ERG-negative prostate cancers.",
keywords = "Adaptor Proteins, Signal Transducing, Adenocarcinoma, Aged, Cell Nucleus, Cell Proliferation, Humans, Male, Middle Aged, Neoplasm Grading, Neoplasm Recurrence, Local, Neoplasm Staging, Nuclear Proteins, Prognosis, Prostate-Specific Antigen, Prostatectomy, Prostatic Neoplasms, Tissue Array Analysis, Trans-Activators, Tumor Markers, Biological",
author = "Tsourlakis, {Maria Christina} and Michael Schoop and Christoph Pla{\ss} and Hartwig Huland and Markus Graefen and Thomas Steuber and Thorsten Schlomm and Ronald Simon and Guido Sauter and H{\"u}seyin Sirma and Sarah Minner",
note = "Copyright {\textcopyright} 2013 Elsevier Inc. All rights reserved.",
year = "2013",
month = sep,
day = "1",
doi = "10.1016/j.humpath.2013.01.022",
language = "English",
volume = "44",
pages = "1789--96",
journal = "HUM PATHOL",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "9",

}

RIS

TY - JOUR

T1 - Overexpression of the chromatin remodeler death-domain-associated protein in prostate cancer is an independent predictor of early prostate-specific antigen recurrence

AU - Tsourlakis, Maria Christina

AU - Schoop, Michael

AU - Plaß, Christoph

AU - Huland, Hartwig

AU - Graefen, Markus

AU - Steuber, Thomas

AU - Schlomm, Thorsten

AU - Simon, Ronald

AU - Sauter, Guido

AU - Sirma, Hüseyin

AU - Minner, Sarah

N1 - Copyright © 2013 Elsevier Inc. All rights reserved.

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Molecular markers reliably predicting the aggressiveness of prostate cancer are currently lacking. Death-domain-associated protein (DAXX) has been implicated in the regulation of chromatin remodeling, transcription, and apoptosis that are integral to oncogenesis and cancer progression. DAXX expression was analyzed by immunohistochemistry on a tissue microarray containing 7478 prostate cancer specimens. Results were compared with tumor phenotype, biochemical recurrence, and v-ets erythroblastosis virus E26 oncogene homolog (ERG) status. DAXX expression was predominantly seen in the nucleus. DAXX expression was detectable in 4609 (80.6%) of 5718 interpretable cancers and considered strong in 5.9%, moderate in 45.8%, and weak in 28.9%. Strong DAXX expression was associated with both transmembrane protease, serine 2 (TMPRSS2)/ERG rearrangement and ERG expression (P < .0001 each). Strong DAXX expression was tightly linked to high Gleason grade, advanced pT stage, increased cell proliferation index, and early prostate-specific antigen recurrence (P < .0001 each). The prognostic role of DAXX expression was independent of Gleason grade, pT stage, and pN stage. Our study establishes DAXX as a novel independent prognosticator in prostate cancer and suggests an important role of DAXX expression for both prostate cancer development and progression. Furthermore, DAXX appears to exert biologically different effects in ERG-positive and ERG-negative prostate cancers.

AB - Molecular markers reliably predicting the aggressiveness of prostate cancer are currently lacking. Death-domain-associated protein (DAXX) has been implicated in the regulation of chromatin remodeling, transcription, and apoptosis that are integral to oncogenesis and cancer progression. DAXX expression was analyzed by immunohistochemistry on a tissue microarray containing 7478 prostate cancer specimens. Results were compared with tumor phenotype, biochemical recurrence, and v-ets erythroblastosis virus E26 oncogene homolog (ERG) status. DAXX expression was predominantly seen in the nucleus. DAXX expression was detectable in 4609 (80.6%) of 5718 interpretable cancers and considered strong in 5.9%, moderate in 45.8%, and weak in 28.9%. Strong DAXX expression was associated with both transmembrane protease, serine 2 (TMPRSS2)/ERG rearrangement and ERG expression (P < .0001 each). Strong DAXX expression was tightly linked to high Gleason grade, advanced pT stage, increased cell proliferation index, and early prostate-specific antigen recurrence (P < .0001 each). The prognostic role of DAXX expression was independent of Gleason grade, pT stage, and pN stage. Our study establishes DAXX as a novel independent prognosticator in prostate cancer and suggests an important role of DAXX expression for both prostate cancer development and progression. Furthermore, DAXX appears to exert biologically different effects in ERG-positive and ERG-negative prostate cancers.

KW - Adaptor Proteins, Signal Transducing

KW - Adenocarcinoma

KW - Aged

KW - Cell Nucleus

KW - Cell Proliferation

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasm Grading

KW - Neoplasm Recurrence, Local

KW - Neoplasm Staging

KW - Nuclear Proteins

KW - Prognosis

KW - Prostate-Specific Antigen

KW - Prostatectomy

KW - Prostatic Neoplasms

KW - Tissue Array Analysis

KW - Trans-Activators

KW - Tumor Markers, Biological

U2 - 10.1016/j.humpath.2013.01.022

DO - 10.1016/j.humpath.2013.01.022

M3 - SCORING: Journal article

C2 - 23642739

VL - 44

SP - 1789

EP - 1796

JO - HUM PATHOL

JF - HUM PATHOL

SN - 0046-8177

IS - 9

ER -