Overall Survival After Whole-Brain Radiation Therapy for Intracerebral Metastases from Testicular Cancer
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Overall Survival After Whole-Brain Radiation Therapy for Intracerebral Metastases from Testicular Cancer. / Rades, Dirk; Dziggel, Liesa; Veninga, Theo; Bajrovic, Amira; Schild, Steven E.
in: ANTICANCER RES, Jahrgang 36, Nr. 9, 09.2016, S. 4817-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Overall Survival After Whole-Brain Radiation Therapy for Intracerebral Metastases from Testicular Cancer
AU - Rades, Dirk
AU - Dziggel, Liesa
AU - Veninga, Theo
AU - Bajrovic, Amira
AU - Schild, Steven E
N1 - Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
PY - 2016/9
Y1 - 2016/9
N2 - BACKGROUND/AIM: To identify predictors and develop a score for overall survival of patients with intracerebral metastasis from testicular cancer.PATIENTS AND METHODS: Whole-brain radiation therapy program, age, Karnofsky performance score (KPS), number of intracerebral metastases, number of other metastatic sites and time between testicular cancer diagnosis and radiation therapy were analyzed for their association with overall survival in eight patients.RESULTS: KPS of 80-90% was significantly associated with better overall survival (p=0.006), one or no other metastatic sites showed a trend for a better outcome (p=0.10). The following scores were assigned: KPS 60-70%=0 points, KPS 80-90%=1 point, ≥2 other metastatic sites=0 points, 0-1 other metastatic sites=1 point. Two groups, with 0 and with 1-2 points, were formed. Overall survival rates were 33% vs. 100% at 6 months and 0% vs. 100% at 12 months (p=0.006), respectively.CONCLUSION: A simple instrument enabling physicians to judge the overall survival of patients with intracerebral metastasis from testicular cancer is provided.
AB - BACKGROUND/AIM: To identify predictors and develop a score for overall survival of patients with intracerebral metastasis from testicular cancer.PATIENTS AND METHODS: Whole-brain radiation therapy program, age, Karnofsky performance score (KPS), number of intracerebral metastases, number of other metastatic sites and time between testicular cancer diagnosis and radiation therapy were analyzed for their association with overall survival in eight patients.RESULTS: KPS of 80-90% was significantly associated with better overall survival (p=0.006), one or no other metastatic sites showed a trend for a better outcome (p=0.10). The following scores were assigned: KPS 60-70%=0 points, KPS 80-90%=1 point, ≥2 other metastatic sites=0 points, 0-1 other metastatic sites=1 point. Two groups, with 0 and with 1-2 points, were formed. Overall survival rates were 33% vs. 100% at 6 months and 0% vs. 100% at 12 months (p=0.006), respectively.CONCLUSION: A simple instrument enabling physicians to judge the overall survival of patients with intracerebral metastasis from testicular cancer is provided.
KW - Adult
KW - Aged
KW - Brain
KW - Brain Neoplasms
KW - Humans
KW - Kaplan-Meier Estimate
KW - Karnofsky Performance Status
KW - Male
KW - Middle Aged
KW - Neoplasm Metastasis
KW - Prognosis
KW - Survival Rate
KW - Testicular Neoplasms
KW - Journal Article
U2 - 10.21873/anticanres.11042
DO - 10.21873/anticanres.11042
M3 - SCORING: Journal article
C2 - 27630334
VL - 36
SP - 4817
EP - 4819
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 9
ER -