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Outcomes in young adults with acute ischemic stroke undergoing endovascular thrombectomy: a real-world multi-center experience

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Outcomes in young adults with acute ischemic stroke undergoing endovascular thrombectomy: a real-world multi-center experience. / Yeo, Leonard Leong-Litt; Chen, Vanessa Hui-En; Leow, Aloysius Sheng-Ting; Meyer, Lukas; Fiehler, Jens; Tu, Tian-Ming; Huilian Tham, Carol; Sia, Ching-Hui; Jamous, Ala; Behme, Daniel; Kastrup, Andreas; Papanagiotou, Panagiotis; Styczen, Hanna; Forsting, Michael; Lee, Tsong-Hai; Chu, Chan-Lin; Fischer, Sebastian; Maus, Volker; Abdullayev, Nuran; Kabbasch, Christoph; Mönch, Sebastian; Maegerlein, Christian; Arnberg, Fabian; Andersson, Tommy; Holmin, Staffan; Teoh, Hock-Luen; Paliwal, Prakash; Ahmad, Aftab; Gopinathan, Anil; Yang, Cunli; Seet, Raymond Chee-Seong; Chan, Bernard Poon-Lap; Sharma, Vijay K; Tan, Benjamin Yong-Qiang.

in: EUR J NEUROL, Jahrgang 28, Nr. 8, 08.2021, S. 2736-2744.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Yeo, LL-L, Chen, VH-E, Leow, AS-T, Meyer, L, Fiehler, J, Tu, T-M, Huilian Tham, C, Sia, C-H, Jamous, A, Behme, D, Kastrup, A, Papanagiotou, P, Styczen, H, Forsting, M, Lee, T-H, Chu, C-L, Fischer, S, Maus, V, Abdullayev, N, Kabbasch, C, Mönch, S, Maegerlein, C, Arnberg, F, Andersson, T, Holmin, S, Teoh, H-L, Paliwal, P, Ahmad, A, Gopinathan, A, Yang, C, Seet, RC-S, Chan, BP-L, Sharma, VK & Tan, BY-Q 2021, 'Outcomes in young adults with acute ischemic stroke undergoing endovascular thrombectomy: a real-world multi-center experience', EUR J NEUROL, Jg. 28, Nr. 8, S. 2736-2744. https://doi.org/10.1111/ene.14899

APA

Yeo, L. L-L., Chen, V. H-E., Leow, A. S-T., Meyer, L., Fiehler, J., Tu, T-M., Huilian Tham, C., Sia, C-H., Jamous, A., Behme, D., Kastrup, A., Papanagiotou, P., Styczen, H., Forsting, M., Lee, T-H., Chu, C-L., Fischer, S., Maus, V., Abdullayev, N., ... Tan, B. Y-Q. (2021). Outcomes in young adults with acute ischemic stroke undergoing endovascular thrombectomy: a real-world multi-center experience. EUR J NEUROL, 28(8), 2736-2744. https://doi.org/10.1111/ene.14899

Vancouver

Yeo LL-L, Chen VH-E, Leow AS-T, Meyer L, Fiehler J, Tu T-M et al. Outcomes in young adults with acute ischemic stroke undergoing endovascular thrombectomy: a real-world multi-center experience. EUR J NEUROL. 2021 Aug;28(8):2736-2744. https://doi.org/10.1111/ene.14899

Bibtex

@article{58e488e822cc44dba783fb5d75aad78f,
title = "Outcomes in young adults with acute ischemic stroke undergoing endovascular thrombectomy: a real-world multi-center experience",
abstract = "Endovascular thrombectomy (EVT) is the standard of care for anterior circulation acute ischemic stroke (AIS) with large vessel occlusion (LVO). Young patients with AIS-LVO have distinctly different underlying stroke mechanisms and etiologies. Much is unknown about the safety and efficacy of EVT in this population of young AIS-LVO patients. All consecutive AIS-LVO patients aged 50 years and below were included in this multicenter cohort study. The primary outcome measured was functional recovery at 90 days, with modified Rankin Scale of 0-2 deemed as good functional outcome. A total of 275 AIS-LVO patients that underwent EVT from 10 tertiary centers in Germany, Sweden, Singapore, and Taiwan were included. Successful reperfusion was achieved in 85.1% (234/275). Good functional outcomes were achieved in 66.0% (182/275). Arterial dissection was the most prevalent stroke etiology (42/195, 21.5%). National Institutes of Health Stroke Scale (NIHSS) score at presentation was inversely related to good functional outcomes (aOR: 0.92, 95% CI: 0.88-0.96 per point increase, p < 0.001). Successful reperfusion (aOR: 3.22, 95% CI: 1.44-7.21, p = 0.005), higher ASPECTS (aOR: 1.21, 95% CI: 1.01-1.44, p = 0.036), and bridging intravenous thrombolysis (aOR: 2.37, 95% CI: 1.29-4.34, p = 0.005) independently predicted good functional outcomes. Successful reperfusion was inversely associated with in-hospital mortality (aOR: 0.14, 95% CI: 0.03-0.57, p = 0.006). History of hypertension strongly predicted in-hospital mortality (aOR: 4.59, 95% CI: 1.10-19.13, p = 0.036). While differences in functional outcomes exist across varying stroke aetiologies, high rates of successful reperfusion and good outcomes are generally achieved in young AIS-LVO patients undergoing EVT.",
keywords = "Brain Ischemia/complications, Cohort Studies, Endovascular Procedures, Humans, Ischemic Stroke, Retrospective Studies, Stroke/surgery, Thrombectomy, Treatment Outcome, Young Adult",
author = "Yeo, {Leonard Leong-Litt} and Chen, {Vanessa Hui-En} and Leow, {Aloysius Sheng-Ting} and Lukas Meyer and Jens Fiehler and Tian-Ming Tu and {Huilian Tham}, Carol and Ching-Hui Sia and Ala Jamous and Daniel Behme and Andreas Kastrup and Panagiotis Papanagiotou and Hanna Styczen and Michael Forsting and Tsong-Hai Lee and Chan-Lin Chu and Sebastian Fischer and Volker Maus and Nuran Abdullayev and Christoph Kabbasch and Sebastian M{\"o}nch and Christian Maegerlein and Fabian Arnberg and Tommy Andersson and Staffan Holmin and Hock-Luen Teoh and Prakash Paliwal and Aftab Ahmad and Anil Gopinathan and Cunli Yang and Seet, {Raymond Chee-Seong} and Chan, {Bernard Poon-Lap} and Sharma, {Vijay K} and Tan, {Benjamin Yong-Qiang}",
note = "{\textcopyright} 2021 European Academy of Neurology.",
year = "2021",
month = aug,
doi = "10.1111/ene.14899",
language = "English",
volume = "28",
pages = "2736--2744",
journal = "EUR J NEUROL",
issn = "1351-5101",
publisher = "Wiley-Blackwell",
number = "8",

}

RIS

TY - JOUR

T1 - Outcomes in young adults with acute ischemic stroke undergoing endovascular thrombectomy: a real-world multi-center experience

AU - Yeo, Leonard Leong-Litt

AU - Chen, Vanessa Hui-En

AU - Leow, Aloysius Sheng-Ting

AU - Meyer, Lukas

AU - Fiehler, Jens

AU - Tu, Tian-Ming

AU - Huilian Tham, Carol

AU - Sia, Ching-Hui

AU - Jamous, Ala

AU - Behme, Daniel

AU - Kastrup, Andreas

AU - Papanagiotou, Panagiotis

AU - Styczen, Hanna

AU - Forsting, Michael

AU - Lee, Tsong-Hai

AU - Chu, Chan-Lin

AU - Fischer, Sebastian

AU - Maus, Volker

AU - Abdullayev, Nuran

AU - Kabbasch, Christoph

AU - Mönch, Sebastian

AU - Maegerlein, Christian

AU - Arnberg, Fabian

AU - Andersson, Tommy

AU - Holmin, Staffan

AU - Teoh, Hock-Luen

AU - Paliwal, Prakash

AU - Ahmad, Aftab

AU - Gopinathan, Anil

AU - Yang, Cunli

AU - Seet, Raymond Chee-Seong

AU - Chan, Bernard Poon-Lap

AU - Sharma, Vijay K

AU - Tan, Benjamin Yong-Qiang

N1 - © 2021 European Academy of Neurology.

PY - 2021/8

Y1 - 2021/8

N2 - Endovascular thrombectomy (EVT) is the standard of care for anterior circulation acute ischemic stroke (AIS) with large vessel occlusion (LVO). Young patients with AIS-LVO have distinctly different underlying stroke mechanisms and etiologies. Much is unknown about the safety and efficacy of EVT in this population of young AIS-LVO patients. All consecutive AIS-LVO patients aged 50 years and below were included in this multicenter cohort study. The primary outcome measured was functional recovery at 90 days, with modified Rankin Scale of 0-2 deemed as good functional outcome. A total of 275 AIS-LVO patients that underwent EVT from 10 tertiary centers in Germany, Sweden, Singapore, and Taiwan were included. Successful reperfusion was achieved in 85.1% (234/275). Good functional outcomes were achieved in 66.0% (182/275). Arterial dissection was the most prevalent stroke etiology (42/195, 21.5%). National Institutes of Health Stroke Scale (NIHSS) score at presentation was inversely related to good functional outcomes (aOR: 0.92, 95% CI: 0.88-0.96 per point increase, p < 0.001). Successful reperfusion (aOR: 3.22, 95% CI: 1.44-7.21, p = 0.005), higher ASPECTS (aOR: 1.21, 95% CI: 1.01-1.44, p = 0.036), and bridging intravenous thrombolysis (aOR: 2.37, 95% CI: 1.29-4.34, p = 0.005) independently predicted good functional outcomes. Successful reperfusion was inversely associated with in-hospital mortality (aOR: 0.14, 95% CI: 0.03-0.57, p = 0.006). History of hypertension strongly predicted in-hospital mortality (aOR: 4.59, 95% CI: 1.10-19.13, p = 0.036). While differences in functional outcomes exist across varying stroke aetiologies, high rates of successful reperfusion and good outcomes are generally achieved in young AIS-LVO patients undergoing EVT.

AB - Endovascular thrombectomy (EVT) is the standard of care for anterior circulation acute ischemic stroke (AIS) with large vessel occlusion (LVO). Young patients with AIS-LVO have distinctly different underlying stroke mechanisms and etiologies. Much is unknown about the safety and efficacy of EVT in this population of young AIS-LVO patients. All consecutive AIS-LVO patients aged 50 years and below were included in this multicenter cohort study. The primary outcome measured was functional recovery at 90 days, with modified Rankin Scale of 0-2 deemed as good functional outcome. A total of 275 AIS-LVO patients that underwent EVT from 10 tertiary centers in Germany, Sweden, Singapore, and Taiwan were included. Successful reperfusion was achieved in 85.1% (234/275). Good functional outcomes were achieved in 66.0% (182/275). Arterial dissection was the most prevalent stroke etiology (42/195, 21.5%). National Institutes of Health Stroke Scale (NIHSS) score at presentation was inversely related to good functional outcomes (aOR: 0.92, 95% CI: 0.88-0.96 per point increase, p < 0.001). Successful reperfusion (aOR: 3.22, 95% CI: 1.44-7.21, p = 0.005), higher ASPECTS (aOR: 1.21, 95% CI: 1.01-1.44, p = 0.036), and bridging intravenous thrombolysis (aOR: 2.37, 95% CI: 1.29-4.34, p = 0.005) independently predicted good functional outcomes. Successful reperfusion was inversely associated with in-hospital mortality (aOR: 0.14, 95% CI: 0.03-0.57, p = 0.006). History of hypertension strongly predicted in-hospital mortality (aOR: 4.59, 95% CI: 1.10-19.13, p = 0.036). While differences in functional outcomes exist across varying stroke aetiologies, high rates of successful reperfusion and good outcomes are generally achieved in young AIS-LVO patients undergoing EVT.

KW - Brain Ischemia/complications

KW - Cohort Studies

KW - Endovascular Procedures

KW - Humans

KW - Ischemic Stroke

KW - Retrospective Studies

KW - Stroke/surgery

KW - Thrombectomy

KW - Treatment Outcome

KW - Young Adult

U2 - 10.1111/ene.14899

DO - 10.1111/ene.14899

M3 - SCORING: Journal article

C2 - 33960072

VL - 28

SP - 2736

EP - 2744

JO - EUR J NEUROL

JF - EUR J NEUROL

SN - 1351-5101

IS - 8

ER -