Outcomes in patients with dual antegrade conduction in the atrioventricular node: insights from a multicentre observational study
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Outcomes in patients with dual antegrade conduction in the atrioventricular node: insights from a multicentre observational study. / Hartmann, Jens; Jungen, Christiane; Stec, Sebastian; Klatt, Niklas; Willems, Stephan; Makimoto, Hisaki; Steven, Daniel; Pürerfellner, Helmut; Martinek, Martin; Meyer, Christian.
in: CLIN RES CARDIOL, Jahrgang 109, Nr. 8, 08.2020, S. 1025-1034.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Outcomes in patients with dual antegrade conduction in the atrioventricular node: insights from a multicentre observational study
AU - Hartmann, Jens
AU - Jungen, Christiane
AU - Stec, Sebastian
AU - Klatt, Niklas
AU - Willems, Stephan
AU - Makimoto, Hisaki
AU - Steven, Daniel
AU - Pürerfellner, Helmut
AU - Martinek, Martin
AU - Meyer, Christian
PY - 2020/8
Y1 - 2020/8
N2 - BACKGROUND: Supraventricular tachycardias induced by dual antegrade conduction via the atrioventricular (AV) node are rare but often misdiagnosed with severe consequences for the affected patients. As long-term follow-up in these patients was not available so far, this study investigates outcomes in patients with dual antegrade conduction in the AV node.METHODS AND RESULTS: In this multicentre observational study, patients from six European centres were studied. Catheter ablation was performed in 17 patients (52 ± 16 years) with dual antegrade conduction via both AV nodal pathways between 2012 and 2018. Patients with the final diagnosis of a manifest dual AV nodal non-re-entrant tachycardia had a mean delay of the correct diagnosis of over 1 year (range 2-31 months). Two patients received prescription of non-indicated oral anticoagulation, two further patients suffered from inappropriate shocks of an implantable cardioverter defibrillator. In 12 patients, a co-existence of dual antegrade and re-entry conduction in the AV node was present. Mean fast pathway conduction time was 138 ± 61 ms and mean slow pathway conduction time was 593 ± 134 ms. Successful radiofrequency catheter ablation was performed in all patients. Post-procedurally oral anticoagulation was discontinued, without detection of cerebrovascular events or atrial fibrillation during a long-term follow-up of median 17 months (range 6-72 months).CONCLUSION: This first multicentre study investigating patients with supraventricular tachycardia and dual antegrade conduction in the AV node demonstrates that catheter ablation is safe and effective while long-term patient outcome is good. Autonomic tone dependent changes in ante- vs. retrograde conduction via slow and/or fast pathway can challenge the diagnosis and therapy in some patients.
AB - BACKGROUND: Supraventricular tachycardias induced by dual antegrade conduction via the atrioventricular (AV) node are rare but often misdiagnosed with severe consequences for the affected patients. As long-term follow-up in these patients was not available so far, this study investigates outcomes in patients with dual antegrade conduction in the AV node.METHODS AND RESULTS: In this multicentre observational study, patients from six European centres were studied. Catheter ablation was performed in 17 patients (52 ± 16 years) with dual antegrade conduction via both AV nodal pathways between 2012 and 2018. Patients with the final diagnosis of a manifest dual AV nodal non-re-entrant tachycardia had a mean delay of the correct diagnosis of over 1 year (range 2-31 months). Two patients received prescription of non-indicated oral anticoagulation, two further patients suffered from inappropriate shocks of an implantable cardioverter defibrillator. In 12 patients, a co-existence of dual antegrade and re-entry conduction in the AV node was present. Mean fast pathway conduction time was 138 ± 61 ms and mean slow pathway conduction time was 593 ± 134 ms. Successful radiofrequency catheter ablation was performed in all patients. Post-procedurally oral anticoagulation was discontinued, without detection of cerebrovascular events or atrial fibrillation during a long-term follow-up of median 17 months (range 6-72 months).CONCLUSION: This first multicentre study investigating patients with supraventricular tachycardia and dual antegrade conduction in the AV node demonstrates that catheter ablation is safe and effective while long-term patient outcome is good. Autonomic tone dependent changes in ante- vs. retrograde conduction via slow and/or fast pathway can challenge the diagnosis and therapy in some patients.
KW - Atrioventricular Node/physiopathology
KW - Catheter Ablation/methods
KW - Electrocardiography
KW - Female
KW - Follow-Up Studies
KW - Heart Rate/physiology
KW - Humans
KW - Male
KW - Middle Aged
KW - Retrospective Studies
KW - Tachycardia, Atrioventricular Nodal Reentry/diagnosis
KW - Treatment Outcome
U2 - 10.1007/s00392-020-01596-y
DO - 10.1007/s00392-020-01596-y
M3 - SCORING: Journal article
C2 - 32002633
VL - 109
SP - 1025
EP - 1034
JO - CLIN RES CARDIOL
JF - CLIN RES CARDIOL
SN - 1861-0684
IS - 8
ER -