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Outcome and fewer indications for adjuvant therapy for patients with oral squamous cell carcinomas under standardized tumor board conditions

Standard

Outcome and fewer indications for adjuvant therapy for patients with oral squamous cell carcinomas under standardized tumor board conditions. / Gröbe, Alexander; Rybak, Lena; Schön, Gerhard; Smeets, Ralf; Tribius, Silke; Schafhausen, Philippe; Clauditz, Till S; Hanken, Henning; Heiland, Max.

in: J CANCER RES CLIN, Jahrgang 142, Nr. 2, 02.2016, S. 505-20.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gröbe, A, Rybak, L, Schön, G, Smeets, R, Tribius, S, Schafhausen, P, Clauditz, TS, Hanken, H & Heiland, M 2016, 'Outcome and fewer indications for adjuvant therapy for patients with oral squamous cell carcinomas under standardized tumor board conditions', J CANCER RES CLIN, Jg. 142, Nr. 2, S. 505-20. https://doi.org/10.1007/s00432-015-2058-3

APA

Gröbe, A., Rybak, L., Schön, G., Smeets, R., Tribius, S., Schafhausen, P., Clauditz, T. S., Hanken, H., & Heiland, M. (2016). Outcome and fewer indications for adjuvant therapy for patients with oral squamous cell carcinomas under standardized tumor board conditions. J CANCER RES CLIN, 142(2), 505-20. https://doi.org/10.1007/s00432-015-2058-3

Vancouver

Gröbe A, Rybak L, Schön G, Smeets R, Tribius S, Schafhausen P et al. Outcome and fewer indications for adjuvant therapy for patients with oral squamous cell carcinomas under standardized tumor board conditions. J CANCER RES CLIN. 2016 Feb;142(2):505-20. https://doi.org/10.1007/s00432-015-2058-3

Bibtex

@article{fc463426dabb444797e390b208d30980,
title = "Outcome and fewer indications for adjuvant therapy for patients with oral squamous cell carcinomas under standardized tumor board conditions",
abstract = "PURPOSE: The aim of our study was to review the outcome of patients with oral squamous cell carcinoma (OSCC) treated according to the current diagnostic and treatment protocols [{"}Tumor Board Group{"} (TBG)] compared to patients diagnosed before the introduction of standardized and certified guidelines [{"}Conventional Group{"} (CG)]. We also analyzed the influence of prognostic factors on overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) rates.METHODS: A total of 321 patients (TBG 95 patients and CG 226 patients) with histologically confirmed OSCC were included in our study. RFS, DFS and OS rates were analyzed by Kaplan-Meier estimates. Cox regression was performed for multivariate analysis of prognostic factors. Results were statistically significant with a p value of <0.05.RESULTS: T, N, AJCC stage, age and therapy resulted to be independent risk factors for OS and DFS. We were not able to identify statistically significant prognostic factors for RFS apart from grading. 31.58 % of patients from the TBG received postoperative adjuvant treatment compared to 74.78 % within the CG. The OS rate was 79.63 % at 30 months for patients from the TBG in comparison with 65.54 % for patients from the CG.CONCLUSION: The implementation of standardized guidelines including the establishment of the {"}Tumor Board Conference{"} results in a higher percentage of patients receiving surgery as only treatment and in better OS rates. To further support this positive trend, patients shall be followed longer and analyzed in future. T, N and M as well as AJCC stage were identified as most important prognostic factors for OS and DFS in our study.",
author = "Alexander Gr{\"o}be and Lena Rybak and Gerhard Sch{\"o}n and Ralf Smeets and Silke Tribius and Philippe Schafhausen and Clauditz, {Till S} and Henning Hanken and Max Heiland",
year = "2016",
month = feb,
doi = "10.1007/s00432-015-2058-3",
language = "English",
volume = "142",
pages = "505--20",
journal = "J CANCER RES CLIN",
issn = "0171-5216",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Outcome and fewer indications for adjuvant therapy for patients with oral squamous cell carcinomas under standardized tumor board conditions

AU - Gröbe, Alexander

AU - Rybak, Lena

AU - Schön, Gerhard

AU - Smeets, Ralf

AU - Tribius, Silke

AU - Schafhausen, Philippe

AU - Clauditz, Till S

AU - Hanken, Henning

AU - Heiland, Max

PY - 2016/2

Y1 - 2016/2

N2 - PURPOSE: The aim of our study was to review the outcome of patients with oral squamous cell carcinoma (OSCC) treated according to the current diagnostic and treatment protocols ["Tumor Board Group" (TBG)] compared to patients diagnosed before the introduction of standardized and certified guidelines ["Conventional Group" (CG)]. We also analyzed the influence of prognostic factors on overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) rates.METHODS: A total of 321 patients (TBG 95 patients and CG 226 patients) with histologically confirmed OSCC were included in our study. RFS, DFS and OS rates were analyzed by Kaplan-Meier estimates. Cox regression was performed for multivariate analysis of prognostic factors. Results were statistically significant with a p value of <0.05.RESULTS: T, N, AJCC stage, age and therapy resulted to be independent risk factors for OS and DFS. We were not able to identify statistically significant prognostic factors for RFS apart from grading. 31.58 % of patients from the TBG received postoperative adjuvant treatment compared to 74.78 % within the CG. The OS rate was 79.63 % at 30 months for patients from the TBG in comparison with 65.54 % for patients from the CG.CONCLUSION: The implementation of standardized guidelines including the establishment of the "Tumor Board Conference" results in a higher percentage of patients receiving surgery as only treatment and in better OS rates. To further support this positive trend, patients shall be followed longer and analyzed in future. T, N and M as well as AJCC stage were identified as most important prognostic factors for OS and DFS in our study.

AB - PURPOSE: The aim of our study was to review the outcome of patients with oral squamous cell carcinoma (OSCC) treated according to the current diagnostic and treatment protocols ["Tumor Board Group" (TBG)] compared to patients diagnosed before the introduction of standardized and certified guidelines ["Conventional Group" (CG)]. We also analyzed the influence of prognostic factors on overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) rates.METHODS: A total of 321 patients (TBG 95 patients and CG 226 patients) with histologically confirmed OSCC were included in our study. RFS, DFS and OS rates were analyzed by Kaplan-Meier estimates. Cox regression was performed for multivariate analysis of prognostic factors. Results were statistically significant with a p value of <0.05.RESULTS: T, N, AJCC stage, age and therapy resulted to be independent risk factors for OS and DFS. We were not able to identify statistically significant prognostic factors for RFS apart from grading. 31.58 % of patients from the TBG received postoperative adjuvant treatment compared to 74.78 % within the CG. The OS rate was 79.63 % at 30 months for patients from the TBG in comparison with 65.54 % for patients from the CG.CONCLUSION: The implementation of standardized guidelines including the establishment of the "Tumor Board Conference" results in a higher percentage of patients receiving surgery as only treatment and in better OS rates. To further support this positive trend, patients shall be followed longer and analyzed in future. T, N and M as well as AJCC stage were identified as most important prognostic factors for OS and DFS in our study.

U2 - 10.1007/s00432-015-2058-3

DO - 10.1007/s00432-015-2058-3

M3 - SCORING: Journal article

C2 - 26507888

VL - 142

SP - 505

EP - 520

JO - J CANCER RES CLIN

JF - J CANCER RES CLIN

SN - 0171-5216

IS - 2

ER -