Osteonecrosis in children with acute lymphoblastic leukemia at initial diagnosis and prior to any chemotherapy
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Osteonecrosis in children with acute lymphoblastic leukemia at initial diagnosis and prior to any chemotherapy. / Krull, Kathinka; Kunstreich, Marina; Bronsema, Annika; Bleckmann, Kirsten; Classen, Carl-Friedrich; Erdlenbruch, Bernhard; Jorch, Norbert; Kolb, Reinhard; Leipold, Alfred; Moser, Olga; Prokop, Aram; Scheurlen, Wolfram; Steinbach, Daniel; Klasen-Sansone, Janina; Klee, Dirk; Escherich, Gabriele; Moericke, Anja; Schrappe, Martin; Borkhardt, Arndt; Kuhlen, Michaela.
in: LEUKEMIA LYMPHOMA, Jahrgang 60, Nr. 1, 01.2019, S. 78-84.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Osteonecrosis in children with acute lymphoblastic leukemia at initial diagnosis and prior to any chemotherapy
AU - Krull, Kathinka
AU - Kunstreich, Marina
AU - Bronsema, Annika
AU - Bleckmann, Kirsten
AU - Classen, Carl-Friedrich
AU - Erdlenbruch, Bernhard
AU - Jorch, Norbert
AU - Kolb, Reinhard
AU - Leipold, Alfred
AU - Moser, Olga
AU - Prokop, Aram
AU - Scheurlen, Wolfram
AU - Steinbach, Daniel
AU - Klasen-Sansone, Janina
AU - Klee, Dirk
AU - Escherich, Gabriele
AU - Moericke, Anja
AU - Schrappe, Martin
AU - Borkhardt, Arndt
AU - Kuhlen, Michaela
PY - 2019/1
Y1 - 2019/1
N2 - Osteonecrosis (ON) is a common and debilitating side effect of anti-leukemic treatment in children with acute lymphoblastic leukemia (ALL). However, the impact of leukemia itself on ON development remains elusive. We analyzed 76 children enrolled in the ongoing OPAL trial, who had magnetic resonance imaging (MRI) studies at diagnosis. MRI screening revealed 14 osteonecrotic lesions (5 × hips, 9 × knees) of any grade (I-III) in 7 (9.2%) patients. Six months on, the number of ON per patient increased (1 patient), remained constant (2), and decreased (2). The severity increased from grade I to II in two patients, remained constant (1), completely resolved (2), and decreased from grade III to osteoedema (1). No differences between adolescents initially presenting with/without ON were observed concerning age, pubertal stage, body mass index, leukemia characteristics, and clinical presentation. In MRI screening, a remarkable number of adolescents with ALL present with ON at diagnosis. The course of these ON remains highly unpredictable.
AB - Osteonecrosis (ON) is a common and debilitating side effect of anti-leukemic treatment in children with acute lymphoblastic leukemia (ALL). However, the impact of leukemia itself on ON development remains elusive. We analyzed 76 children enrolled in the ongoing OPAL trial, who had magnetic resonance imaging (MRI) studies at diagnosis. MRI screening revealed 14 osteonecrotic lesions (5 × hips, 9 × knees) of any grade (I-III) in 7 (9.2%) patients. Six months on, the number of ON per patient increased (1 patient), remained constant (2), and decreased (2). The severity increased from grade I to II in two patients, remained constant (1), completely resolved (2), and decreased from grade III to osteoedema (1). No differences between adolescents initially presenting with/without ON were observed concerning age, pubertal stage, body mass index, leukemia characteristics, and clinical presentation. In MRI screening, a remarkable number of adolescents with ALL present with ON at diagnosis. The course of these ON remains highly unpredictable.
KW - Journal Article
U2 - 10.1080/10428194.2018.1466292
DO - 10.1080/10428194.2018.1466292
M3 - SCORING: Journal article
C2 - 29718744
VL - 60
SP - 78
EP - 84
JO - LEUKEMIA LYMPHOMA
JF - LEUKEMIA LYMPHOMA
SN - 1042-8194
IS - 1
ER -
