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Osteonecrosis develops independently from radiological leukemic infiltration of bone in adolescents with acute lymphoblastic leukemia - first findings of the OPAL trial

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Osteonecrosis develops independently from radiological leukemic infiltration of bone in adolescents with acute lymphoblastic leukemia - first findings of the OPAL trial. / Krull, Kathinka; Kunstreich, Marina; Klasen-Sansone, Janina; Kloetgen, Andreas; Gruener, Franziska; Escherich, Gabriele; Bleckmann, Kirsten; Moericke, Anja; Schrappe, Martin; Jorch, Norbert; Steinbach, Daniel; Classen, Carl-Friedrich; Guggemos, Andreas; Kolb, Reinhard; Klee, Dirk; Borkhardt, Arndt; Kuhlen, Michaela.

in: LEUKEMIA LYMPHOMA, Jahrgang 58, Nr. 10, 10.2017, S. 2363-2369.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Krull, K, Kunstreich, M, Klasen-Sansone, J, Kloetgen, A, Gruener, F, Escherich, G, Bleckmann, K, Moericke, A, Schrappe, M, Jorch, N, Steinbach, D, Classen, C-F, Guggemos, A, Kolb, R, Klee, D, Borkhardt, A & Kuhlen, M 2017, 'Osteonecrosis develops independently from radiological leukemic infiltration of bone in adolescents with acute lymphoblastic leukemia - first findings of the OPAL trial', LEUKEMIA LYMPHOMA, Jg. 58, Nr. 10, S. 2363-2369. https://doi.org/10.1080/10428194.2017.1280605

APA

Krull, K., Kunstreich, M., Klasen-Sansone, J., Kloetgen, A., Gruener, F., Escherich, G., Bleckmann, K., Moericke, A., Schrappe, M., Jorch, N., Steinbach, D., Classen, C-F., Guggemos, A., Kolb, R., Klee, D., Borkhardt, A., & Kuhlen, M. (2017). Osteonecrosis develops independently from radiological leukemic infiltration of bone in adolescents with acute lymphoblastic leukemia - first findings of the OPAL trial. LEUKEMIA LYMPHOMA, 58(10), 2363-2369. https://doi.org/10.1080/10428194.2017.1280605

Vancouver

Krull K, Kunstreich M, Klasen-Sansone J, Kloetgen A, Gruener F, Escherich G et al. Osteonecrosis develops independently from radiological leukemic infiltration of bone in adolescents with acute lymphoblastic leukemia - first findings of the OPAL trial. LEUKEMIA LYMPHOMA. 2017 Okt;58(10):2363-2369. https://doi.org/10.1080/10428194.2017.1280605

Bibtex

@article{e6191b04b71540cab6e0708929c59b1e,
title = "Osteonecrosis develops independently from radiological leukemic infiltration of bone in adolescents with acute lymphoblastic leukemia - first findings of the OPAL trial",
abstract = "Osteonecrosis (ON) is a debilitating side effect of anti-leukemic treatment. Thus far, the role of leukemic infiltration (LI) of bone is unclear. The first 30 children aged ≥10 years, who were enrolled in the ongoing OPAL trial and had MRI studies at diagnosis and at 6 months, were analyzed. MRI revealed extensive LIs in 24 (80%) patients. The signal abnormalities changed back to a physiological signal in 29 out of 30 children at 6 months. Of the 24 children with LIs at diagnosis, 3 (12.5%) developed ON ≥ II, whereas 4 (66.7%) patients without LIs subsequently developed ON ≥ II (p = .016). No differences between children initially presenting with/without LIs were observed concerning age, pubertal stage, white blood count, immunophenotype, and clinical presentation. Initial radiological LI of bone and, thus, single MRI at diagnosis cannot identify children at high risk of developing radiological ON at 6 months into treatment.",
author = "Kathinka Krull and Marina Kunstreich and Janina Klasen-Sansone and Andreas Kloetgen and Franziska Gruener and Gabriele Escherich and Kirsten Bleckmann and Anja Moericke and Martin Schrappe and Norbert Jorch and Daniel Steinbach and Carl-Friedrich Classen and Andreas Guggemos and Reinhard Kolb and Dirk Klee and Arndt Borkhardt and Michaela Kuhlen",
year = "2017",
month = oct,
doi = "10.1080/10428194.2017.1280605",
language = "English",
volume = "58",
pages = "2363--2369",
journal = "LEUKEMIA LYMPHOMA",
issn = "1042-8194",
publisher = "informa healthcare",
number = "10",

}

RIS

TY - JOUR

T1 - Osteonecrosis develops independently from radiological leukemic infiltration of bone in adolescents with acute lymphoblastic leukemia - first findings of the OPAL trial

AU - Krull, Kathinka

AU - Kunstreich, Marina

AU - Klasen-Sansone, Janina

AU - Kloetgen, Andreas

AU - Gruener, Franziska

AU - Escherich, Gabriele

AU - Bleckmann, Kirsten

AU - Moericke, Anja

AU - Schrappe, Martin

AU - Jorch, Norbert

AU - Steinbach, Daniel

AU - Classen, Carl-Friedrich

AU - Guggemos, Andreas

AU - Kolb, Reinhard

AU - Klee, Dirk

AU - Borkhardt, Arndt

AU - Kuhlen, Michaela

PY - 2017/10

Y1 - 2017/10

N2 - Osteonecrosis (ON) is a debilitating side effect of anti-leukemic treatment. Thus far, the role of leukemic infiltration (LI) of bone is unclear. The first 30 children aged ≥10 years, who were enrolled in the ongoing OPAL trial and had MRI studies at diagnosis and at 6 months, were analyzed. MRI revealed extensive LIs in 24 (80%) patients. The signal abnormalities changed back to a physiological signal in 29 out of 30 children at 6 months. Of the 24 children with LIs at diagnosis, 3 (12.5%) developed ON ≥ II, whereas 4 (66.7%) patients without LIs subsequently developed ON ≥ II (p = .016). No differences between children initially presenting with/without LIs were observed concerning age, pubertal stage, white blood count, immunophenotype, and clinical presentation. Initial radiological LI of bone and, thus, single MRI at diagnosis cannot identify children at high risk of developing radiological ON at 6 months into treatment.

AB - Osteonecrosis (ON) is a debilitating side effect of anti-leukemic treatment. Thus far, the role of leukemic infiltration (LI) of bone is unclear. The first 30 children aged ≥10 years, who were enrolled in the ongoing OPAL trial and had MRI studies at diagnosis and at 6 months, were analyzed. MRI revealed extensive LIs in 24 (80%) patients. The signal abnormalities changed back to a physiological signal in 29 out of 30 children at 6 months. Of the 24 children with LIs at diagnosis, 3 (12.5%) developed ON ≥ II, whereas 4 (66.7%) patients without LIs subsequently developed ON ≥ II (p = .016). No differences between children initially presenting with/without LIs were observed concerning age, pubertal stage, white blood count, immunophenotype, and clinical presentation. Initial radiological LI of bone and, thus, single MRI at diagnosis cannot identify children at high risk of developing radiological ON at 6 months into treatment.

U2 - 10.1080/10428194.2017.1280605

DO - 10.1080/10428194.2017.1280605

M3 - SCORING: Journal article

C2 - 28140726

VL - 58

SP - 2363

EP - 2369

JO - LEUKEMIA LYMPHOMA

JF - LEUKEMIA LYMPHOMA

SN - 1042-8194

IS - 10

ER -