Optical coherence tomography for tissue classification of the larynx in an outpatient setting-a translational challenge on the verge of a resolution?
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Optical coherence tomography for tissue classification of the larynx in an outpatient setting-a translational challenge on the verge of a resolution? / Wittig, Lukas; Betz, Christian; Eggert, Dennis.
in: Translational Biophotonics, Jahrgang n/a, Nr. n/a, 2020, S. e202000013.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Optical coherence tomography for tissue classification of the larynx in an outpatient setting-a translational challenge on the verge of a resolution?
AU - Wittig, Lukas
AU - Betz, Christian
AU - Eggert, Dennis
N1 - https://doi.org/10.1002/tbio.202000013
PY - 2020
Y1 - 2020
N2 - Abstract The detection and tissue classification of mucosal lesions of the upper aerodigestive tract (UADT) is crucial for the development of a treatment plan. Using modern endoscopic examination techniques mucosal changes can be detected early on in an office-based setting. However, the further classification of these lesions requires a surgical procedure with a biopsy taken under general anesthesia. Optical coherence tomography (OCT) is a noninvasive, light-based optical tool which can provide high-resolution cross-sectional images of tissue at near microscopic resolution. Applying it through a single mode optical fiber allows endoscopic approaches. Routine endoscopic assessment and a thin epithelial layer makes the larynx the perfect organ for implementing OCT into the clinical endoscopic routine. This review is focused on summarizing previous and ongoing translational applications of OCT imaging for tissue classification in the UADT focusing on the larynx, discussing limitations and benefits and offering an outlook on possible future applications.
AB - Abstract The detection and tissue classification of mucosal lesions of the upper aerodigestive tract (UADT) is crucial for the development of a treatment plan. Using modern endoscopic examination techniques mucosal changes can be detected early on in an office-based setting. However, the further classification of these lesions requires a surgical procedure with a biopsy taken under general anesthesia. Optical coherence tomography (OCT) is a noninvasive, light-based optical tool which can provide high-resolution cross-sectional images of tissue at near microscopic resolution. Applying it through a single mode optical fiber allows endoscopic approaches. Routine endoscopic assessment and a thin epithelial layer makes the larynx the perfect organ for implementing OCT into the clinical endoscopic routine. This review is focused on summarizing previous and ongoing translational applications of OCT imaging for tissue classification in the UADT focusing on the larynx, discussing limitations and benefits and offering an outlook on possible future applications.
KW - cancer
KW - deep learning
KW - larynx
KW - mucosal lesion
KW - optical coherence tomography
KW - upper aerodigestive tract
U2 - 10.1002/tbio.202000013
DO - 10.1002/tbio.202000013
M3 - SCORING: Review
VL - n/a
SP - e202000013
IS - n/a
ER -