Opioid activities of human beta-casomorphins.
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Opioid activities of human beta-casomorphins. / Koch, G; Wiedemann, Klaus; Teschemacher, H.
in: N-S ARCH PHARMACOL, Jahrgang 331, Nr. 4, 4, 1985, S. 351-354.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Opioid activities of human beta-casomorphins.
AU - Koch, G
AU - Wiedemann, Klaus
AU - Teschemacher, H
PY - 1985
Y1 - 1985
N2 - Opioid activities of human beta-casomorphin-4, -5, -7 and -8 and, for comparison, of the corresponding bovine beta-casomorphins were studied in the guinea-pig ileum preparation. Binding parameters, i.e. KD-values and binding site concentrations, for the interaction of human and bovine beta-casomorphins with opioid receptors in rat brain homogenates were determined in inhibition experiments, using [3H]-(D-Ala2, MePhe4, Gly-ol5)enkephalin, [3H]-(D-Ala2, D-Leu5)enkephalin and [3H]ethylketazocin as mu-, delta- and kappa-opioid receptor ligands. Analysis of binding data was performed using a non-linear curve fitting program. All beta-casomorphins examined displayed opioid activity. The affinity was highest for mu-receptors, less so for delta-receptors and lowest for kappa-receptors. It is suggested that human beta-casomorphins might play a role as "food hormones".
AB - Opioid activities of human beta-casomorphin-4, -5, -7 and -8 and, for comparison, of the corresponding bovine beta-casomorphins were studied in the guinea-pig ileum preparation. Binding parameters, i.e. KD-values and binding site concentrations, for the interaction of human and bovine beta-casomorphins with opioid receptors in rat brain homogenates were determined in inhibition experiments, using [3H]-(D-Ala2, MePhe4, Gly-ol5)enkephalin, [3H]-(D-Ala2, D-Leu5)enkephalin and [3H]ethylketazocin as mu-, delta- and kappa-opioid receptor ligands. Analysis of binding data was performed using a non-linear curve fitting program. All beta-casomorphins examined displayed opioid activity. The affinity was highest for mu-receptors, less so for delta-receptors and lowest for kappa-receptors. It is suggested that human beta-casomorphins might play a role as "food hormones".
M3 - SCORING: Zeitschriftenaufsatz
VL - 331
SP - 351
EP - 354
JO - N-S ARCH PHARMACOL
JF - N-S ARCH PHARMACOL
SN - 0028-1298
IS - 4
M1 - 4
ER -
