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Onset of thymic recovery and plateau of thymic output are differentially regulated after stem cell transplantation in children

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Onset of thymic recovery and plateau of thymic output are differentially regulated after stem cell transplantation in children. / Eyrich, Matthias; Wollny, Gernot; Tzaribaschev, Nikolaj; Dietz, Klaus; Brügger, Dorothee; Bader, Peter; Lang, Peter; Schilbach, Karin; Winkler, Beate; Niethammer, Dietrich; Schlegel, Paul G.

in: BIOL BLOOD MARROW TR, Jahrgang 11, Nr. 3, 03.2005, S. 194-205.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Eyrich, M, Wollny, G, Tzaribaschev, N, Dietz, K, Brügger, D, Bader, P, Lang, P, Schilbach, K, Winkler, B, Niethammer, D & Schlegel, PG 2005, 'Onset of thymic recovery and plateau of thymic output are differentially regulated after stem cell transplantation in children', BIOL BLOOD MARROW TR, Jg. 11, Nr. 3, S. 194-205. https://doi.org/10.1016/j.bbmt.2004.12.001

APA

Eyrich, M., Wollny, G., Tzaribaschev, N., Dietz, K., Brügger, D., Bader, P., Lang, P., Schilbach, K., Winkler, B., Niethammer, D., & Schlegel, P. G. (2005). Onset of thymic recovery and plateau of thymic output are differentially regulated after stem cell transplantation in children. BIOL BLOOD MARROW TR, 11(3), 194-205. https://doi.org/10.1016/j.bbmt.2004.12.001

Vancouver

Eyrich M, Wollny G, Tzaribaschev N, Dietz K, Brügger D, Bader P et al. Onset of thymic recovery and plateau of thymic output are differentially regulated after stem cell transplantation in children. BIOL BLOOD MARROW TR. 2005 Mär;11(3):194-205. https://doi.org/10.1016/j.bbmt.2004.12.001

Bibtex

@article{619bd308f9764a6082941d0ebc5edd64,
title = "Onset of thymic recovery and plateau of thymic output are differentially regulated after stem cell transplantation in children",
abstract = "Thymus-dependent T-cell regeneration is a major pathway for immune reconstitution after stem cell transplantation in children. Therefore, we prospectively assessed T-cell dynamics and thymic function in 164 pediatric patients between 1 and 124 months after transplantation by measuring T-cell receptor recombination excision circles and spontaneous expression of Ki67 in peripheral T-cell subsets. We analyzed the effect of recipient age, conditioning regimen, type of donor and graft, stem cell dose, and graft-versus-host disease on the onset and the plateau of thymic output. A high rate of spontaneous proliferation in early-reconstituting naive and memory T cells inversely correlated with total T-cell numbers. Accordingly, T-cell receptor recombination excision circle content was diminished in early-appearing naive T cells. A multivariate analysis revealed that the onset of thymic recovery was inversely correlated only with recipient age ( P < .0002), whereas the plateau of thymic output was higher in patients receiving increased stem cell numbers ( P < .0022). Donor type, stem cell source, and conditioning regimen influenced none of the analyzed parameters. In conclusion, lymphopenia-driven proliferation is important for T-cell homeostasis in children early after stem cell transplantation, but it might result in underestimation of thymic function. Onset and plateau of thymic activity are independently regulated by different transplant-related factors.",
keywords = "Adolescent, Adult, Cell Proliferation, Child, Child, Preschool, Cohort Studies, Gene Rearrangement, T-Lymphocyte, Hematopoietic Stem Cell Transplantation/adverse effects, Homeostasis/immunology, Humans, Infant, Ki-67 Antigen/analysis, Lymphopenia, Multivariate Analysis, Myeloablative Agonists/therapeutic use, Prognosis, Prospective Studies, T-Lymphocyte Subsets/immunology, T-Lymphocytes/cytology, Thymus Gland/cytology, Time Factors, Transplantation Conditioning/adverse effects",
author = "Matthias Eyrich and Gernot Wollny and Nikolaj Tzaribaschev and Klaus Dietz and Dorothee Br{\"u}gger and Peter Bader and Peter Lang and Karin Schilbach and Beate Winkler and Dietrich Niethammer and Schlegel, {Paul G}",
year = "2005",
month = mar,
doi = "10.1016/j.bbmt.2004.12.001",
language = "English",
volume = "11",
pages = "194--205",
journal = "BIOL BLOOD MARROW TR",
issn = "1083-8791",
publisher = "Elsevier Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Onset of thymic recovery and plateau of thymic output are differentially regulated after stem cell transplantation in children

AU - Eyrich, Matthias

AU - Wollny, Gernot

AU - Tzaribaschev, Nikolaj

AU - Dietz, Klaus

AU - Brügger, Dorothee

AU - Bader, Peter

AU - Lang, Peter

AU - Schilbach, Karin

AU - Winkler, Beate

AU - Niethammer, Dietrich

AU - Schlegel, Paul G

PY - 2005/3

Y1 - 2005/3

N2 - Thymus-dependent T-cell regeneration is a major pathway for immune reconstitution after stem cell transplantation in children. Therefore, we prospectively assessed T-cell dynamics and thymic function in 164 pediatric patients between 1 and 124 months after transplantation by measuring T-cell receptor recombination excision circles and spontaneous expression of Ki67 in peripheral T-cell subsets. We analyzed the effect of recipient age, conditioning regimen, type of donor and graft, stem cell dose, and graft-versus-host disease on the onset and the plateau of thymic output. A high rate of spontaneous proliferation in early-reconstituting naive and memory T cells inversely correlated with total T-cell numbers. Accordingly, T-cell receptor recombination excision circle content was diminished in early-appearing naive T cells. A multivariate analysis revealed that the onset of thymic recovery was inversely correlated only with recipient age ( P < .0002), whereas the plateau of thymic output was higher in patients receiving increased stem cell numbers ( P < .0022). Donor type, stem cell source, and conditioning regimen influenced none of the analyzed parameters. In conclusion, lymphopenia-driven proliferation is important for T-cell homeostasis in children early after stem cell transplantation, but it might result in underestimation of thymic function. Onset and plateau of thymic activity are independently regulated by different transplant-related factors.

AB - Thymus-dependent T-cell regeneration is a major pathway for immune reconstitution after stem cell transplantation in children. Therefore, we prospectively assessed T-cell dynamics and thymic function in 164 pediatric patients between 1 and 124 months after transplantation by measuring T-cell receptor recombination excision circles and spontaneous expression of Ki67 in peripheral T-cell subsets. We analyzed the effect of recipient age, conditioning regimen, type of donor and graft, stem cell dose, and graft-versus-host disease on the onset and the plateau of thymic output. A high rate of spontaneous proliferation in early-reconstituting naive and memory T cells inversely correlated with total T-cell numbers. Accordingly, T-cell receptor recombination excision circle content was diminished in early-appearing naive T cells. A multivariate analysis revealed that the onset of thymic recovery was inversely correlated only with recipient age ( P < .0002), whereas the plateau of thymic output was higher in patients receiving increased stem cell numbers ( P < .0022). Donor type, stem cell source, and conditioning regimen influenced none of the analyzed parameters. In conclusion, lymphopenia-driven proliferation is important for T-cell homeostasis in children early after stem cell transplantation, but it might result in underestimation of thymic function. Onset and plateau of thymic activity are independently regulated by different transplant-related factors.

KW - Adolescent

KW - Adult

KW - Cell Proliferation

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Gene Rearrangement, T-Lymphocyte

KW - Hematopoietic Stem Cell Transplantation/adverse effects

KW - Homeostasis/immunology

KW - Humans

KW - Infant

KW - Ki-67 Antigen/analysis

KW - Lymphopenia

KW - Multivariate Analysis

KW - Myeloablative Agonists/therapeutic use

KW - Prognosis

KW - Prospective Studies

KW - T-Lymphocyte Subsets/immunology

KW - T-Lymphocytes/cytology

KW - Thymus Gland/cytology

KW - Time Factors

KW - Transplantation Conditioning/adverse effects

U2 - 10.1016/j.bbmt.2004.12.001

DO - 10.1016/j.bbmt.2004.12.001

M3 - SCORING: Journal article

C2 - 15744238

VL - 11

SP - 194

EP - 205

JO - BIOL BLOOD MARROW TR

JF - BIOL BLOOD MARROW TR

SN - 1083-8791

IS - 3

ER -