PortalPublikationenOnset and spreading patterns of upper and lower motor neuron...

Onset and spreading patterns of upper and lower motor neuron symptoms in amyotrophic lateral sclerosis

Standard

Onset and spreading patterns of upper and lower motor neuron symptoms in amyotrophic lateral sclerosis. / Körner, Sonja; Kollewe, Katja; Fahlbusch, Marion; Zapf, Antonia; Dengler, Reinhard; Krampfl, Klaus; Petri, Susanne.

in: MUSCLE NERVE, Jahrgang 43, Nr. 5, 05.2011, S. 636-642.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Körner, S, Kollewe, K, Fahlbusch, M, Zapf, A, Dengler, R, Krampfl, K & Petri, S 2011, 'Onset and spreading patterns of upper and lower motor neuron symptoms in amyotrophic lateral sclerosis', MUSCLE NERVE, Jg. 43, Nr. 5, S. 636-642. https://doi.org/10.1002/mus.21936

APA

Körner, S., Kollewe, K., Fahlbusch, M., Zapf, A., Dengler, R., Krampfl, K., & Petri, S. (2011). Onset and spreading patterns of upper and lower motor neuron symptoms in amyotrophic lateral sclerosis. MUSCLE NERVE, 43(5), 636-642. https://doi.org/10.1002/mus.21936

Vancouver

Körner S, Kollewe K, Fahlbusch M, Zapf A, Dengler R, Krampfl K et al. Onset and spreading patterns of upper and lower motor neuron symptoms in amyotrophic lateral sclerosis. MUSCLE NERVE. 2011 Mai;43(5):636-642. https://doi.org/10.1002/mus.21936

Bibtex

@article{e3b648ce7cb94019ab58865cb58f5e07,
title = "Onset and spreading patterns of upper and lower motor neuron symptoms in amyotrophic lateral sclerosis",
abstract = "INTRODUCTION: The potential linkage between upper (UMN) and lower motor neuron (LMN) involvement in amyotrophic lateral sclerosis (ALS) has not yet been fully elucidated. There is ongoing discussion as to whether ALS is primarily a disease of UMNs or LMNs.METHODS: We performed a retrospective analysis of 189 ALS patients from our ALS outpatient database to investigate the different spreading patterns of UMN and LMN affection in disease progression in relation to the onset region.RESULTS: The body region with the highest UMN involvement at onset in general also had the highest frequency of LMN signs and vice versa. This is in line with the hypothesis of a focal onset of disease, which then spreads to adjacent areas. However, there was a great variation between ALS phenotypes.DISCUSSION: These observations support the hypothesis of focal damage of a localized group of motor neurons, which then spreads to adjacent motor neurons.",
keywords = "Adult, Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis, Cohort Studies, Disease Progression, Electromyography, Female, Humans, Male, Middle Aged, Motor Neuron Disease, Motor Neurons, Muscle, Skeletal, Retrospective Studies, Comparative Study, Journal Article",
author = "Sonja K{\"o}rner and Katja Kollewe and Marion Fahlbusch and Antonia Zapf and Reinhard Dengler and Klaus Krampfl and Susanne Petri",
note = "Copyright {\textcopyright} 2010 Wiley Periodicals, Inc.",
year = "2011",
month = may,
doi = "10.1002/mus.21936",
language = "English",
volume = "43",
pages = "636--642",
journal = "MUSCLE NERVE",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Onset and spreading patterns of upper and lower motor neuron symptoms in amyotrophic lateral sclerosis

AU - Körner, Sonja

AU - Kollewe, Katja

AU - Fahlbusch, Marion

AU - Zapf, Antonia

AU - Dengler, Reinhard

AU - Krampfl, Klaus

AU - Petri, Susanne

N1 - Copyright © 2010 Wiley Periodicals, Inc.

PY - 2011/5

Y1 - 2011/5

N2 - INTRODUCTION: The potential linkage between upper (UMN) and lower motor neuron (LMN) involvement in amyotrophic lateral sclerosis (ALS) has not yet been fully elucidated. There is ongoing discussion as to whether ALS is primarily a disease of UMNs or LMNs.METHODS: We performed a retrospective analysis of 189 ALS patients from our ALS outpatient database to investigate the different spreading patterns of UMN and LMN affection in disease progression in relation to the onset region.RESULTS: The body region with the highest UMN involvement at onset in general also had the highest frequency of LMN signs and vice versa. This is in line with the hypothesis of a focal onset of disease, which then spreads to adjacent areas. However, there was a great variation between ALS phenotypes.DISCUSSION: These observations support the hypothesis of focal damage of a localized group of motor neurons, which then spreads to adjacent motor neurons.

AB - INTRODUCTION: The potential linkage between upper (UMN) and lower motor neuron (LMN) involvement in amyotrophic lateral sclerosis (ALS) has not yet been fully elucidated. There is ongoing discussion as to whether ALS is primarily a disease of UMNs or LMNs.METHODS: We performed a retrospective analysis of 189 ALS patients from our ALS outpatient database to investigate the different spreading patterns of UMN and LMN affection in disease progression in relation to the onset region.RESULTS: The body region with the highest UMN involvement at onset in general also had the highest frequency of LMN signs and vice versa. This is in line with the hypothesis of a focal onset of disease, which then spreads to adjacent areas. However, there was a great variation between ALS phenotypes.DISCUSSION: These observations support the hypothesis of focal damage of a localized group of motor neurons, which then spreads to adjacent motor neurons.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Amyotrophic Lateral Sclerosis

KW - Cohort Studies

KW - Disease Progression

KW - Electromyography

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Motor Neuron Disease

KW - Motor Neurons

KW - Muscle, Skeletal

KW - Retrospective Studies

KW - Comparative Study

KW - Journal Article

U2 - 10.1002/mus.21936

DO - 10.1002/mus.21936

M3 - SCORING: Journal article

C2 - 21484822

VL - 43

SP - 636

EP - 642

JO - MUSCLE NERVE

JF - MUSCLE NERVE

SN - 0148-639X

IS - 5

ER -