On the fracture behavior of cortical bone microstructure: The effects of morphology and material characteristics of bone structural components
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On the fracture behavior of cortical bone microstructure: The effects of morphology and material characteristics of bone structural components. / Allahyari, P; Silani, M; Yaghoubi, V; Milovanovic, P; Schmidt, F N; Busse, B; Qwamizadeh, M.
in: J MECH BEHAV BIOMED, Jahrgang 137, 105530, 01.2023.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - On the fracture behavior of cortical bone microstructure: The effects of morphology and material characteristics of bone structural components
AU - Allahyari, P
AU - Silani, M
AU - Yaghoubi, V
AU - Milovanovic, P
AU - Schmidt, F N
AU - Busse, B
AU - Qwamizadeh, M
N1 - Copyright © 2022 Elsevier Ltd. All rights reserved.
PY - 2023/1
Y1 - 2023/1
N2 - Bone encompasses a complex arrangement of materials at different length scales, which endows it with a range of mechanical, chemical, and biological capabilities. Changes in the microstructure and characteristics of the material, as well as the accumulation of microcracks, affect the bone fracture properties. In this study, two-dimensional finite element models of the microstructure of cortical bone were considered. The eXtended Finite Element Method (XFEM) developed by Abaqus software was used for the analysis of the microcrack propagation in the model as well as for local sensitivity analysis. The stress-strain behavior obtained for the different introduced models was substantially different, confirming the importance of bone tissue microstructure for its failure behavior. Considering the role of interfaces, the results highlighted the effect of cement lines on the crack deflection path and global fracture behavior of the bone microstructure. Furthermore, bone micromorphology and areal fraction of cortical bone tissue components such as osteons, cement lines, and pores affected the bone fracture behavior; specifically, pores altered the crack propagation path since increasing porosity reduced the maximum stress needed to start crack propagation. Therefore, cement line structure, mineralization, and areal fraction are important parameters in bone fracture. The parameter-wise sensitivity analysis demonstrated that areal fraction and strain energy release rate had the greatest and the lowest effect on ultimate strength, respectively. Furthermore, the component-wise sensitivity analysis revealed that for the areal fraction parameter, pores had the greatest effect on ultimate strength, whereas for the other parameters such as elastic modulus and strain energy release rate, cement lines had the most important effect on the ultimate strength. In conclusion, the finding of the current study can help to predict the fracture mechanisms in bone by taking the morphological and material properties of its microstructure into account.
AB - Bone encompasses a complex arrangement of materials at different length scales, which endows it with a range of mechanical, chemical, and biological capabilities. Changes in the microstructure and characteristics of the material, as well as the accumulation of microcracks, affect the bone fracture properties. In this study, two-dimensional finite element models of the microstructure of cortical bone were considered. The eXtended Finite Element Method (XFEM) developed by Abaqus software was used for the analysis of the microcrack propagation in the model as well as for local sensitivity analysis. The stress-strain behavior obtained for the different introduced models was substantially different, confirming the importance of bone tissue microstructure for its failure behavior. Considering the role of interfaces, the results highlighted the effect of cement lines on the crack deflection path and global fracture behavior of the bone microstructure. Furthermore, bone micromorphology and areal fraction of cortical bone tissue components such as osteons, cement lines, and pores affected the bone fracture behavior; specifically, pores altered the crack propagation path since increasing porosity reduced the maximum stress needed to start crack propagation. Therefore, cement line structure, mineralization, and areal fraction are important parameters in bone fracture. The parameter-wise sensitivity analysis demonstrated that areal fraction and strain energy release rate had the greatest and the lowest effect on ultimate strength, respectively. Furthermore, the component-wise sensitivity analysis revealed that for the areal fraction parameter, pores had the greatest effect on ultimate strength, whereas for the other parameters such as elastic modulus and strain energy release rate, cement lines had the most important effect on the ultimate strength. In conclusion, the finding of the current study can help to predict the fracture mechanisms in bone by taking the morphological and material properties of its microstructure into account.
KW - Humans
KW - Finite Element Analysis
KW - Models, Biological
KW - Cortical Bone
KW - Fractures, Bone
KW - Bone and Bones
KW - Stress, Mechanical
U2 - 10.1016/j.jmbbm.2022.105530
DO - 10.1016/j.jmbbm.2022.105530
M3 - SCORING: Journal article
C2 - 36334581
VL - 137
JO - J MECH BEHAV BIOMED
JF - J MECH BEHAV BIOMED
SN - 1751-6161
M1 - 105530
ER -