Occupational airborne exposure, specific sensitization and the atopic Status: evidence of a complex interrelationship
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Occupational airborne exposure, specific sensitization and the atopic Status: evidence of a complex interrelationship. / Baur, Xaver; Barbinova, Lioubov.
in: J OCCUP MED TOXICOL, Jahrgang 8, Nr. 1, 01.01.2013, S. 2.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Occupational airborne exposure, specific sensitization and the atopic Status: evidence of a complex interrelationship
AU - Baur, Xaver
AU - Barbinova, Lioubov
PY - 2013/1/1
Y1 - 2013/1/1
N2 - BACKGROUND: We have investigated the relationship between atopic status and long-term occupational exposure to latex proteins or methyl diethyl diisocyanate (MDI) as high and low molecular weight asthma-inducing agents, respectively.METHODS: This study is based on retrospective analyses of two groups of symptomatic outpatients: 184 healthcare workers with latex exposure and 156 workers with isocyanate (MDI) exposure. We analysed atopic and non-atopic subgroups according to exposure duration and the frequencies of specific sensitization.RESULTS: 45% of the healthcare subgroup specifically sensitized to latex were atopic, whereas in the non-sensitized healthcare subgroup only 26% were atopic. On the other hand, subjects specifically sensitized to MDI were rarely atopic (only 15%), whereas in the subgroup non-sensitized to MDI atopy was present in 38%. After prolonged durations of exposure, the proportion of atopics was further elevated in most healthcare subgroups but it decreased in the MDI-exposed subjects.CONCLUSIONS: We hypothesize that latex proteins as sensitizing agents might promote the development of atopy, whereas exposure to the low molecular weight MDI might inhibit the atopic status.
AB - BACKGROUND: We have investigated the relationship between atopic status and long-term occupational exposure to latex proteins or methyl diethyl diisocyanate (MDI) as high and low molecular weight asthma-inducing agents, respectively.METHODS: This study is based on retrospective analyses of two groups of symptomatic outpatients: 184 healthcare workers with latex exposure and 156 workers with isocyanate (MDI) exposure. We analysed atopic and non-atopic subgroups according to exposure duration and the frequencies of specific sensitization.RESULTS: 45% of the healthcare subgroup specifically sensitized to latex were atopic, whereas in the non-sensitized healthcare subgroup only 26% were atopic. On the other hand, subjects specifically sensitized to MDI were rarely atopic (only 15%), whereas in the subgroup non-sensitized to MDI atopy was present in 38%. After prolonged durations of exposure, the proportion of atopics was further elevated in most healthcare subgroups but it decreased in the MDI-exposed subjects.CONCLUSIONS: We hypothesize that latex proteins as sensitizing agents might promote the development of atopy, whereas exposure to the low molecular weight MDI might inhibit the atopic status.
U2 - 10.1186/1745-6673-8-2
DO - 10.1186/1745-6673-8-2
M3 - SCORING: Journal article
C2 - 23406275
VL - 8
SP - 2
JO - J OCCUP MED TOXICOL
JF - J OCCUP MED TOXICOL
SN - 1745-6673
IS - 1
ER -