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NT-pro-B-type natriuretic peptide in infants and children: reference values based on combined data from four studies

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NT-pro-B-type natriuretic peptide in infants and children: reference values based on combined data from four studies. / Nir, Amiram; Lindinger, Angelika; Rauh, Manfred; Bar-Oz, Benjamin; Laer, Stephanie; Schwachtgen, Lynn; Koch, Andreas; Falkenberg, Jan; Mir, Thomas S.

in: PEDIATR CARDIOL, Jahrgang 30, Nr. 1, 01.2009, S. 3-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Nir, A, Lindinger, A, Rauh, M, Bar-Oz, B, Laer, S, Schwachtgen, L, Koch, A, Falkenberg, J & Mir, TS 2009, 'NT-pro-B-type natriuretic peptide in infants and children: reference values based on combined data from four studies', PEDIATR CARDIOL, Jg. 30, Nr. 1, S. 3-8. https://doi.org/10.1007/s00246-008-9258-4

APA

Nir, A., Lindinger, A., Rauh, M., Bar-Oz, B., Laer, S., Schwachtgen, L., Koch, A., Falkenberg, J., & Mir, T. S. (2009). NT-pro-B-type natriuretic peptide in infants and children: reference values based on combined data from four studies. PEDIATR CARDIOL, 30(1), 3-8. https://doi.org/10.1007/s00246-008-9258-4

Vancouver

Nir A, Lindinger A, Rauh M, Bar-Oz B, Laer S, Schwachtgen L et al. NT-pro-B-type natriuretic peptide in infants and children: reference values based on combined data from four studies. PEDIATR CARDIOL. 2009 Jan;30(1):3-8. https://doi.org/10.1007/s00246-008-9258-4

Bibtex

@article{561926ab1b8f460c95f22b2db70012bf,
title = "NT-pro-B-type natriuretic peptide in infants and children: reference values based on combined data from four studies",
abstract = "In cardiology, B-type natriuretic peptide and the amino terminal segment of its prohormone (NT-proBNP) are important biomarkers. The importance of these peptides as markers for heart disease in pediatric cardiology is reviewed. The peptide levels are dependent on age, assay, and possibly gender. The normal value range and upper limits for infants and children are needed. To determine reference values, data were combined from four studies that measured NT-proBNP levels in normal infants and children using the same electrochemiluminescence assay. The age intervals for the upper limits of normal were chosen for intervals in which no age-dependent change was observed. Statistical analysis was performed on log-transformed data. A total of 690 subjects (47% males) ages birth to 18 years were included in the review. The levels of NT-proBNP were highest in the first days of life, then showed a marked decline in the first week or weeks. The peptide levels continued to decline gradually with age (r = 0.43; p < 0.001). Male and female levels differed only for children ages 10 to 14 years. However, the upper limit of normal did not differ between the boys and girls in any age group. The findings lead to the conclusion that B-type natriuretic peptide (BNP) and NT-proBNP are important markers for heart disease in pediatric cardiology. The levels of NT-proBNP are highest in the first days of life and decrease drastically thereafter. A mild gradual decline occurs with age throughout childhood. Girls have somewhat higher levels of NT-proBNP during puberty.",
keywords = "Adolescent, Age Factors, Biomarkers/blood, Child, Child, Preschool, Electrochemical Techniques, Female, Heart Diseases/blood, Humans, Infant, Infant, Newborn, Luminescence, Male, Natriuretic Peptide, Brain/blood, Peptide Fragments/blood, Reference Values, Sex Factors",
author = "Amiram Nir and Angelika Lindinger and Manfred Rauh and Benjamin Bar-Oz and Stephanie Laer and Lynn Schwachtgen and Andreas Koch and Jan Falkenberg and Mir, {Thomas S}",
year = "2009",
month = jan,
doi = "10.1007/s00246-008-9258-4",
language = "English",
volume = "30",
pages = "3--8",
journal = "PEDIATR CARDIOL",
issn = "0172-0643",
publisher = "Springer New York",
number = "1",

}

RIS

TY - JOUR

T1 - NT-pro-B-type natriuretic peptide in infants and children: reference values based on combined data from four studies

AU - Nir, Amiram

AU - Lindinger, Angelika

AU - Rauh, Manfred

AU - Bar-Oz, Benjamin

AU - Laer, Stephanie

AU - Schwachtgen, Lynn

AU - Koch, Andreas

AU - Falkenberg, Jan

AU - Mir, Thomas S

PY - 2009/1

Y1 - 2009/1

N2 - In cardiology, B-type natriuretic peptide and the amino terminal segment of its prohormone (NT-proBNP) are important biomarkers. The importance of these peptides as markers for heart disease in pediatric cardiology is reviewed. The peptide levels are dependent on age, assay, and possibly gender. The normal value range and upper limits for infants and children are needed. To determine reference values, data were combined from four studies that measured NT-proBNP levels in normal infants and children using the same electrochemiluminescence assay. The age intervals for the upper limits of normal were chosen for intervals in which no age-dependent change was observed. Statistical analysis was performed on log-transformed data. A total of 690 subjects (47% males) ages birth to 18 years were included in the review. The levels of NT-proBNP were highest in the first days of life, then showed a marked decline in the first week or weeks. The peptide levels continued to decline gradually with age (r = 0.43; p < 0.001). Male and female levels differed only for children ages 10 to 14 years. However, the upper limit of normal did not differ between the boys and girls in any age group. The findings lead to the conclusion that B-type natriuretic peptide (BNP) and NT-proBNP are important markers for heart disease in pediatric cardiology. The levels of NT-proBNP are highest in the first days of life and decrease drastically thereafter. A mild gradual decline occurs with age throughout childhood. Girls have somewhat higher levels of NT-proBNP during puberty.

AB - In cardiology, B-type natriuretic peptide and the amino terminal segment of its prohormone (NT-proBNP) are important biomarkers. The importance of these peptides as markers for heart disease in pediatric cardiology is reviewed. The peptide levels are dependent on age, assay, and possibly gender. The normal value range and upper limits for infants and children are needed. To determine reference values, data were combined from four studies that measured NT-proBNP levels in normal infants and children using the same electrochemiluminescence assay. The age intervals for the upper limits of normal were chosen for intervals in which no age-dependent change was observed. Statistical analysis was performed on log-transformed data. A total of 690 subjects (47% males) ages birth to 18 years were included in the review. The levels of NT-proBNP were highest in the first days of life, then showed a marked decline in the first week or weeks. The peptide levels continued to decline gradually with age (r = 0.43; p < 0.001). Male and female levels differed only for children ages 10 to 14 years. However, the upper limit of normal did not differ between the boys and girls in any age group. The findings lead to the conclusion that B-type natriuretic peptide (BNP) and NT-proBNP are important markers for heart disease in pediatric cardiology. The levels of NT-proBNP are highest in the first days of life and decrease drastically thereafter. A mild gradual decline occurs with age throughout childhood. Girls have somewhat higher levels of NT-proBNP during puberty.

KW - Adolescent

KW - Age Factors

KW - Biomarkers/blood

KW - Child

KW - Child, Preschool

KW - Electrochemical Techniques

KW - Female

KW - Heart Diseases/blood

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Luminescence

KW - Male

KW - Natriuretic Peptide, Brain/blood

KW - Peptide Fragments/blood

KW - Reference Values

KW - Sex Factors

U2 - 10.1007/s00246-008-9258-4

DO - 10.1007/s00246-008-9258-4

M3 - SCORING: Review article

C2 - 18600369

VL - 30

SP - 3

EP - 8

JO - PEDIATR CARDIOL

JF - PEDIATR CARDIOL

SN - 0172-0643

IS - 1

ER -