Novelty-induced behavioral traits correlate with numbers of brainstem noradrenergic neurons and septal cholinergic neurons in C57BL/6J mice.
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Novelty-induced behavioral traits correlate with numbers of brainstem noradrenergic neurons and septal cholinergic neurons in C57BL/6J mice. / Tereshchenko, Yuliya; Brandewiede, Jörg; Schachner, Melitta; Irintchev, Andrey; Morellini, Fabio.
in: BEHAV BRAIN RES, Jahrgang 191, Nr. 2, 2, 2008, S. 280-284.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Novelty-induced behavioral traits correlate with numbers of brainstem noradrenergic neurons and septal cholinergic neurons in C57BL/6J mice.
AU - Tereshchenko, Yuliya
AU - Brandewiede, Jörg
AU - Schachner, Melitta
AU - Irintchev, Andrey
AU - Morellini, Fabio
PY - 2008
Y1 - 2008
N2 - It is generally accepted that different brain regions regulate specific behavioral responses and that structural alterations in these regions may affect behavior. We investigated whether inter-individual variability in novelty-induced behaviors in C57BL/6J mice correlates with numbers of noradrenergic neurons in the locus coeruleus and cholinergic neurons in the septum. We found that exploration of new stimuli correlated negatively with numbers of noradrenergic neurons, whereas anxiety correlated positively with numbers of cholinergic neurons. The observed correlations suggest physiologically plausible links between structure and function and indicate that precise morphological estimates can be predictive for behavioral responses.
AB - It is generally accepted that different brain regions regulate specific behavioral responses and that structural alterations in these regions may affect behavior. We investigated whether inter-individual variability in novelty-induced behaviors in C57BL/6J mice correlates with numbers of noradrenergic neurons in the locus coeruleus and cholinergic neurons in the septum. We found that exploration of new stimuli correlated negatively with numbers of noradrenergic neurons, whereas anxiety correlated positively with numbers of cholinergic neurons. The observed correlations suggest physiologically plausible links between structure and function and indicate that precise morphological estimates can be predictive for behavioral responses.
M3 - SCORING: Zeitschriftenaufsatz
VL - 191
SP - 280
EP - 284
JO - BEHAV BRAIN RES
JF - BEHAV BRAIN RES
SN - 0166-4328
IS - 2
M1 - 2
ER -