Novel cell death program leads to neutrophil extracellular traps
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Novel cell death program leads to neutrophil extracellular traps. / Fuchs, Tobias A; Abed, Ulrike; Goosmann, Christian; Hurwitz, Robert; Schulze, Ilka; Wahn, Volker; Weinrauch, Yvette; Brinkmann, Volker; Zychlinsky, Arturo.
in: J CELL BIOL, Jahrgang 176, Nr. 2, 15.01.2007, S. 231-41.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Novel cell death program leads to neutrophil extracellular traps
AU - Fuchs, Tobias A
AU - Abed, Ulrike
AU - Goosmann, Christian
AU - Hurwitz, Robert
AU - Schulze, Ilka
AU - Wahn, Volker
AU - Weinrauch, Yvette
AU - Brinkmann, Volker
AU - Zychlinsky, Arturo
PY - 2007/1/15
Y1 - 2007/1/15
N2 - Neutrophil extracellular traps (NETs) are extracellular structures composed of chromatin and granule proteins that bind and kill microorganisms. We show that upon stimulation, the nuclei of neutrophils lose their shape, and the eu- and heterochromatin homogenize. Later, the nuclear envelope and the granule membranes disintegrate, allowing the mixing of NET components. Finally, the NETs are released as the cell membrane breaks. This cell death process is distinct from apoptosis and necrosis and depends on the generation of reactive oxygen species (ROS) by NADPH oxidase. Patients with chronic granulomatous disease carry mutations in NADPH oxidase and cannot activate this cell-death pathway or make NETs. This novel ROS-dependent death allows neutrophils to fulfill their antimicrobial function, even beyond their lifespan.
AB - Neutrophil extracellular traps (NETs) are extracellular structures composed of chromatin and granule proteins that bind and kill microorganisms. We show that upon stimulation, the nuclei of neutrophils lose their shape, and the eu- and heterochromatin homogenize. Later, the nuclear envelope and the granule membranes disintegrate, allowing the mixing of NET components. Finally, the NETs are released as the cell membrane breaks. This cell death process is distinct from apoptosis and necrosis and depends on the generation of reactive oxygen species (ROS) by NADPH oxidase. Patients with chronic granulomatous disease carry mutations in NADPH oxidase and cannot activate this cell-death pathway or make NETs. This novel ROS-dependent death allows neutrophils to fulfill their antimicrobial function, even beyond their lifespan.
KW - Antibodies
KW - Antigens, CD95
KW - Apoptosis
KW - Catalase
KW - Cell Death
KW - Cell Survival
KW - Chromatin
KW - Cytoplasmic Granules
KW - Enzyme Inhibitors
KW - Granulomatous Disease, Chronic
KW - Humans
KW - Hydrogen Peroxide
KW - Immunity, Innate
KW - Leukocyte Elastase
KW - Microscopy, Electron
KW - NADPH Oxidase
KW - Neutrophil Activation
KW - Neutrophils
KW - Nuclear Envelope
KW - Onium Compounds
KW - Phagocytosis
KW - Reactive Oxygen Species
KW - Staphylococcus aureus
KW - Tetradecanoylphorbol Acetate
KW - Vacuoles
U2 - 10.1083/jcb.200606027
DO - 10.1083/jcb.200606027
M3 - SCORING: Journal article
C2 - 17210947
VL - 176
SP - 231
EP - 241
JO - J CELL BIOL
JF - J CELL BIOL
SN - 0021-9525
IS - 2
ER -