Noradrenergic arousal after encoding reverses the course of systems consolidation in humans

Valentina Krenz; Tobias Sommer; Arjen Alink; Benno Roozendaal; Lars Schwabe

doi:10.1038/s41467-021-26250-7

Noradrenergic arousal after encoding reverses the course of systems consolidation in humans

Standard

Noradrenergic arousal after encoding reverses the course of systems consolidation in humans. / Krenz, Valentina; Sommer, Tobias ; Alink, Arjen; Roozendaal, Benno; Schwabe, Lars.

in: NAT COMMUN, Jahrgang 12, Nr. 1, 6054, 18.10.2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Krenz, V, Sommer, T , Alink, A, Roozendaal, B & Schwabe, L 2021, 'Noradrenergic arousal after encoding reverses the course of systems consolidation in humans', NAT COMMUN, Jg. 12, Nr. 1, 6054. https://doi.org/10.1038/s41467-021-26250-7

APA

Krenz, V., Sommer, T., Alink, A., Roozendaal, B., & Schwabe, L. (2021). Noradrenergic arousal after encoding reverses the course of systems consolidation in humans. NAT COMMUN, 12(1), [6054]. https://doi.org/10.1038/s41467-021-26250-7

Vancouver

Krenz V, Sommer T , Alink A, Roozendaal B, Schwabe L. Noradrenergic arousal after encoding reverses the course of systems consolidation in humans. NAT COMMUN. 2021 Okt 18;12(1). 6054. https://doi.org/10.1038/s41467-021-26250-7

Bibtex

@article{1cc526f0b30549948c6d30aeaa8b793a,

title = "Noradrenergic arousal after encoding reverses the course of systems consolidation in humans",

abstract = "It is commonly assumed that episodic memories undergo a time-dependent systems consolidation process, during which hippocampus-dependent memories eventually become reliant on neocortical areas. Here we show that systems consolidation dynamics can be experimentally manipulated and even reversed. We combined a single pharmacological elevation of post-encoding noradrenergic activity through the α2-adrenoceptor antagonist yohimbine with fMRI scanning both during encoding and recognition testing either 1 or 28 days later. We show that yohimbine administration, in contrast to placebo, leads to a time-dependent increase in hippocampal activity and multivariate encoding-retrieval pattern similarity, an indicator of episodic reinstatement, between 1 and 28 days. This is accompanied by a time-dependent decrease in neocortical activity. Behaviorally, these neural changes are linked to a reduced memory decline over time after yohimbine intake. These findings indicate that noradrenergic activity shortly after encoding may alter and even reverse systems consolidation in humans, thus maintaining vividness of memories over time.",

author = "Valentina Krenz and Tobias Sommer and Arjen Alink and Benno Roozendaal and Lars Schwabe",

note = "{\textcopyright} 2021. The Author(s).",

year = "2021",

month = oct,

day = "18",

doi = "10.1038/s41467-021-26250-7",

language = "English",

volume = "12",

journal = "NAT COMMUN",

issn = "2041-1723",

publisher = "NATURE PUBLISHING GROUP",

number = "1",

}

RIS

TY - JOUR

T1 - Noradrenergic arousal after encoding reverses the course of systems consolidation in humans

AU - Krenz, Valentina

AU - Sommer, Tobias

AU - Alink, Arjen

AU - Roozendaal, Benno

AU - Schwabe, Lars

PY - 2021/10/18

Y1 - 2021/10/18

N2 - It is commonly assumed that episodic memories undergo a time-dependent systems consolidation process, during which hippocampus-dependent memories eventually become reliant on neocortical areas. Here we show that systems consolidation dynamics can be experimentally manipulated and even reversed. We combined a single pharmacological elevation of post-encoding noradrenergic activity through the α2-adrenoceptor antagonist yohimbine with fMRI scanning both during encoding and recognition testing either 1 or 28 days later. We show that yohimbine administration, in contrast to placebo, leads to a time-dependent increase in hippocampal activity and multivariate encoding-retrieval pattern similarity, an indicator of episodic reinstatement, between 1 and 28 days. This is accompanied by a time-dependent decrease in neocortical activity. Behaviorally, these neural changes are linked to a reduced memory decline over time after yohimbine intake. These findings indicate that noradrenergic activity shortly after encoding may alter and even reverse systems consolidation in humans, thus maintaining vividness of memories over time.

AB - It is commonly assumed that episodic memories undergo a time-dependent systems consolidation process, during which hippocampus-dependent memories eventually become reliant on neocortical areas. Here we show that systems consolidation dynamics can be experimentally manipulated and even reversed. We combined a single pharmacological elevation of post-encoding noradrenergic activity through the α2-adrenoceptor antagonist yohimbine with fMRI scanning both during encoding and recognition testing either 1 or 28 days later. We show that yohimbine administration, in contrast to placebo, leads to a time-dependent increase in hippocampal activity and multivariate encoding-retrieval pattern similarity, an indicator of episodic reinstatement, between 1 and 28 days. This is accompanied by a time-dependent decrease in neocortical activity. Behaviorally, these neural changes are linked to a reduced memory decline over time after yohimbine intake. These findings indicate that noradrenergic activity shortly after encoding may alter and even reverse systems consolidation in humans, thus maintaining vividness of memories over time.

U2 - 10.1038/s41467-021-26250-7

DO - 10.1038/s41467-021-26250-7

M3 - SCORING: Journal article

C2 - 34663784

VL - 12

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

M1 - 6054

ER -