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Non-immune risk predictors of cardiac allograft vasculopathy: Results from the U.S. organ procurement and transplantation network

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Non-immune risk predictors of cardiac allograft vasculopathy: Results from the U.S. organ procurement and transplantation network. / Fluschnik, Nina; Geelhoed, Bastiaan; Becher, Peter Moritz; Schrage, Benedikt; Brunner, Fabian J; Knappe, Dorit; Bernhardt, Alexander M; Blankenberg, Stefan; Kobashigawa, Jon; Reichenspurner, Hermann; Schnabel, Renate B; Magnussen, Christina.

in: INT J CARDIOL, Jahrgang 331, 15.05.2021, S. 57-62.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fluschnik, N, Geelhoed, B, Becher, PM, Schrage, B, Brunner, FJ, Knappe, D, Bernhardt, AM, Blankenberg, S, Kobashigawa, J, Reichenspurner, H, Schnabel, RB & Magnussen, C 2021, 'Non-immune risk predictors of cardiac allograft vasculopathy: Results from the U.S. organ procurement and transplantation network', INT J CARDIOL, Jg. 331, S. 57-62. https://doi.org/10.1016/j.ijcard.2021.02.002

APA

Fluschnik, N., Geelhoed, B., Becher, P. M., Schrage, B., Brunner, F. J., Knappe, D., Bernhardt, A. M., Blankenberg, S., Kobashigawa, J., Reichenspurner, H., Schnabel, R. B., & Magnussen, C. (2021). Non-immune risk predictors of cardiac allograft vasculopathy: Results from the U.S. organ procurement and transplantation network. INT J CARDIOL, 331, 57-62. https://doi.org/10.1016/j.ijcard.2021.02.002

Vancouver

Fluschnik N, Geelhoed B, Becher PM, Schrage B, Brunner FJ, Knappe D et al. Non-immune risk predictors of cardiac allograft vasculopathy: Results from the U.S. organ procurement and transplantation network. INT J CARDIOL. 2021 Mai 15;331:57-62. https://doi.org/10.1016/j.ijcard.2021.02.002

Bibtex

@article{99f8470d3f9d4988b7297568d97fee0b,
title = "Non-immune risk predictors of cardiac allograft vasculopathy: Results from the U.S. organ procurement and transplantation network",
abstract = "BACKGROUND: Cardiac allograft vasculopathy (CAV) remains a major long-term complication in heart transplant (HT) recipients related to increased mortality. We aimed to identify non-immune recipient- and donor-related risk factors for the development of CAV in HT patients.METHODS: 40,647 recipients, prospectively enrolled from April 1995 to January 2019 in the Organ Procurement and Transplantation Network (OPTN), were analyzed after exclusion of pediatric patients, those with missing information on CAV, and re-transplantation. Multivariable-adjusted Cox regression analyses were performed to identify recipient- and donor-related risk factors for CAV. 5-year population attributable risk for classical cardiovascular risk factors was calculated to estimate the recipients' CAV risk. Analyses were based on OPTN data (June 30, 2019).RESULTS: Of 40,647 post-transplant patients, 14,698 (36.2%) developed CAV with a higher incidence in males (37.3%) than in females (32.6%) (p < 0.001). The mean follow-up time was 68.2 months. In recipients, male sex, African American and Asian ethnicity, ischemic cardiomyopathy, body mass index and smoking were associated with CAV occurrence. In donors, older age, male sex, smoking, diabetes and arterial hypertension were related to CAV. Results remained fairly stable after analysis of different time periods. 5-year attributable CAV risk for classical cardiovascular risk factors was 9.1%.CONCLUSIONS: In this large registry with known limitations concerning data completeness, CAV incidence was higher in males than in females. Next to male sex and donor age, the classical cardiovascular risk factors were related to incident CAV. Classical cardiovascular risk factors played only a minor role for the 5-year attributable CAV risk.",
keywords = "Aged, Allografts, Child, Female, Graft Rejection/epidemiology, Heart Diseases, Heart Transplantation/adverse effects, Humans, Male, Retrospective Studies, Risk Factors, Tissue Donors, Tissue and Organ Procurement",
author = "Nina Fluschnik and Bastiaan Geelhoed and Becher, {Peter Moritz} and Benedikt Schrage and Brunner, {Fabian J} and Dorit Knappe and Bernhardt, {Alexander M} and Stefan Blankenberg and Jon Kobashigawa and Hermann Reichenspurner and Schnabel, {Renate B} and Christina Magnussen",
note = "Copyright {\textcopyright} 2021 Elsevier B.V. All rights reserved.",
year = "2021",
month = may,
day = "15",
doi = "10.1016/j.ijcard.2021.02.002",
language = "English",
volume = "331",
pages = "57--62",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Non-immune risk predictors of cardiac allograft vasculopathy: Results from the U.S. organ procurement and transplantation network

AU - Fluschnik, Nina

AU - Geelhoed, Bastiaan

AU - Becher, Peter Moritz

AU - Schrage, Benedikt

AU - Brunner, Fabian J

AU - Knappe, Dorit

AU - Bernhardt, Alexander M

AU - Blankenberg, Stefan

AU - Kobashigawa, Jon

AU - Reichenspurner, Hermann

AU - Schnabel, Renate B

AU - Magnussen, Christina

N1 - Copyright © 2021 Elsevier B.V. All rights reserved.

PY - 2021/5/15

Y1 - 2021/5/15

N2 - BACKGROUND: Cardiac allograft vasculopathy (CAV) remains a major long-term complication in heart transplant (HT) recipients related to increased mortality. We aimed to identify non-immune recipient- and donor-related risk factors for the development of CAV in HT patients.METHODS: 40,647 recipients, prospectively enrolled from April 1995 to January 2019 in the Organ Procurement and Transplantation Network (OPTN), were analyzed after exclusion of pediatric patients, those with missing information on CAV, and re-transplantation. Multivariable-adjusted Cox regression analyses were performed to identify recipient- and donor-related risk factors for CAV. 5-year population attributable risk for classical cardiovascular risk factors was calculated to estimate the recipients' CAV risk. Analyses were based on OPTN data (June 30, 2019).RESULTS: Of 40,647 post-transplant patients, 14,698 (36.2%) developed CAV with a higher incidence in males (37.3%) than in females (32.6%) (p < 0.001). The mean follow-up time was 68.2 months. In recipients, male sex, African American and Asian ethnicity, ischemic cardiomyopathy, body mass index and smoking were associated with CAV occurrence. In donors, older age, male sex, smoking, diabetes and arterial hypertension were related to CAV. Results remained fairly stable after analysis of different time periods. 5-year attributable CAV risk for classical cardiovascular risk factors was 9.1%.CONCLUSIONS: In this large registry with known limitations concerning data completeness, CAV incidence was higher in males than in females. Next to male sex and donor age, the classical cardiovascular risk factors were related to incident CAV. Classical cardiovascular risk factors played only a minor role for the 5-year attributable CAV risk.

AB - BACKGROUND: Cardiac allograft vasculopathy (CAV) remains a major long-term complication in heart transplant (HT) recipients related to increased mortality. We aimed to identify non-immune recipient- and donor-related risk factors for the development of CAV in HT patients.METHODS: 40,647 recipients, prospectively enrolled from April 1995 to January 2019 in the Organ Procurement and Transplantation Network (OPTN), were analyzed after exclusion of pediatric patients, those with missing information on CAV, and re-transplantation. Multivariable-adjusted Cox regression analyses were performed to identify recipient- and donor-related risk factors for CAV. 5-year population attributable risk for classical cardiovascular risk factors was calculated to estimate the recipients' CAV risk. Analyses were based on OPTN data (June 30, 2019).RESULTS: Of 40,647 post-transplant patients, 14,698 (36.2%) developed CAV with a higher incidence in males (37.3%) than in females (32.6%) (p < 0.001). The mean follow-up time was 68.2 months. In recipients, male sex, African American and Asian ethnicity, ischemic cardiomyopathy, body mass index and smoking were associated with CAV occurrence. In donors, older age, male sex, smoking, diabetes and arterial hypertension were related to CAV. Results remained fairly stable after analysis of different time periods. 5-year attributable CAV risk for classical cardiovascular risk factors was 9.1%.CONCLUSIONS: In this large registry with known limitations concerning data completeness, CAV incidence was higher in males than in females. Next to male sex and donor age, the classical cardiovascular risk factors were related to incident CAV. Classical cardiovascular risk factors played only a minor role for the 5-year attributable CAV risk.

KW - Aged

KW - Allografts

KW - Child

KW - Female

KW - Graft Rejection/epidemiology

KW - Heart Diseases

KW - Heart Transplantation/adverse effects

KW - Humans

KW - Male

KW - Retrospective Studies

KW - Risk Factors

KW - Tissue Donors

KW - Tissue and Organ Procurement

U2 - 10.1016/j.ijcard.2021.02.002

DO - 10.1016/j.ijcard.2021.02.002

M3 - SCORING: Journal article

C2 - 33571561

VL - 331

SP - 57

EP - 62

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

ER -