Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin.
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Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin. / Hossaini, Mehdi; Jongen, Joost L M; Biesheuvel, Karla; Kuhl, Dietmar; Holstege, Jan C.
in: MOL PAIN, Jahrgang 6, 2010, S. 43.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin.
AU - Hossaini, Mehdi
AU - Jongen, Joost L M
AU - Biesheuvel, Karla
AU - Kuhl, Dietmar
AU - Holstege, Jan C
PY - 2010
Y1 - 2010
N2 - In pain processing, long term synaptic changes play an important role, especially during chronic pain. The immediate early gene Arc/Arg3.1 has been widely implicated in mediating long-term plasticity in telencephalic regions, such as the hippocampus and cortex. Accordingly, Arc/Arg3.1 knockout (KO) mice show a deficit in long-term memory consolidation. Here, we identify expression of Arc/Arg3.1 in the rat spinal cord using immunohistochemistry and in situ hybridization following pain stimuli.
AB - In pain processing, long term synaptic changes play an important role, especially during chronic pain. The immediate early gene Arc/Arg3.1 has been widely implicated in mediating long-term plasticity in telencephalic regions, such as the hippocampus and cortex. Accordingly, Arc/Arg3.1 knockout (KO) mice show a deficit in long-term memory consolidation. Here, we identify expression of Arc/Arg3.1 in the rat spinal cord using immunohistochemistry and in situ hybridization following pain stimuli.
U2 - 10.1186/1744-8069-6-43
DO - 10.1186/1744-8069-6-43
M3 - SCORING: Zeitschriftenaufsatz
VL - 6
SP - 43
ER -