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No differences in ventral striatum responsivity between adolescents with a positive family history of alcoholism and controls

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No differences in ventral striatum responsivity between adolescents with a positive family history of alcoholism and controls. / Müller, Kathrin U; Gan, Gabriela; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Büchel, Christian; Conrod, Patricia; Fauth-Bühler, Mira; Flor, Herta; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Lawrence, Claire; Loth, Eva; Mann, Karl; Martinot, Jean-Luc; Nees, Frauke; Paus, Tomáš; Pausova, Zdenka; Rietschel, Marcella; Ströhle, Andreas; Struve, Maren; Schumann, Gunter; Smolka, Michael N; IMAGEN Consortium.

in: ADDICT BIOL, Jahrgang 20, Nr. 3, 2014, S. 534-45.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Müller, KU, Gan, G, Banaschewski, T, Barker, GJ, Bokde, ALW, Büchel, C, Conrod, P, Fauth-Bühler, M, Flor, H, Gallinat, J, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Lawrence, C, Loth, E, Mann, K, Martinot, J-L, Nees, F, Paus, T, Pausova, Z, Rietschel, M, Ströhle, A, Struve, M, Schumann, G, Smolka, MN & IMAGEN Consortium 2014, 'No differences in ventral striatum responsivity between adolescents with a positive family history of alcoholism and controls', ADDICT BIOL, Jg. 20, Nr. 3, S. 534-45. https://doi.org/10.1111/adb.12136

APA

Müller, K. U., Gan, G., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., Conrod, P., Fauth-Bühler, M., Flor, H., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Lawrence, C., Loth, E., Mann, K., Martinot, J-L., Nees, F., ... IMAGEN Consortium (2014). No differences in ventral striatum responsivity between adolescents with a positive family history of alcoholism and controls. ADDICT BIOL, 20(3), 534-45. https://doi.org/10.1111/adb.12136

Vancouver

Müller KU, Gan G, Banaschewski T, Barker GJ, Bokde ALW, Büchel C et al. No differences in ventral striatum responsivity between adolescents with a positive family history of alcoholism and controls. ADDICT BIOL. 2014;20(3):534-45. https://doi.org/10.1111/adb.12136

Bibtex

@article{d771b04e26cd4b8d9692fcefcc2748d8,
title = "No differences in ventral striatum responsivity between adolescents with a positive family history of alcoholism and controls",
abstract = "Individuals with alcohol-dependent parents show an elevated risk of developing alcohol-related problems themselves. Modulations of the mesolimbic reward circuit have been postulated as a pre-existing marker of alcoholism. We tested whether a positive family history of alcoholism is correlated with ventral striatum functionality during a reward task. All participants performed a modified version of the monetary incentive delay task while their brain responses were measured with functional magnetic resonance imaging. We compared 206 healthy adolescents (aged 13-15) who had any first- or second-degree relative with alcoholism to 206 matched controls with no biological relative with alcoholism. Reward anticipation as well as feedback of win recruited the ventral striatum in all participants, but adolescents with a positive family history of alcoholism did not differ from their matched peers. Also we did not find any correlation between family history density and reward anticipation or feedback of win. This finding of no differences did not change when we analyzed a subsample of 77 adolescents with at least one parent with alcohol use disorder and their matched controls. Because this result is in line with another study reporting no differences between children with alcohol-dependent parents and controls at young age, but contrasts with studies of older individuals, one might conclude that at younger age the effect of family history has not yet exerted its influence on the still developing mesolimbic reward circuit.",
author = "M{\"u}ller, {Kathrin U} and Gabriela Gan and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Christian B{\"u}chel and Patricia Conrod and Mira Fauth-B{\"u}hler and Herta Flor and J{\"u}rgen Gallinat and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Claire Lawrence and Eva Loth and Karl Mann and Jean-Luc Martinot and Frauke Nees and Tom{\'a}{\v s} Paus and Zdenka Pausova and Marcella Rietschel and Andreas Str{\"o}hle and Maren Struve and Gunter Schumann and Smolka, {Michael N} and {IMAGEN Consortium}",
note = "{\textcopyright} 2014 Society for the Study of Addiction.",
year = "2014",
doi = "10.1111/adb.12136",
language = "English",
volume = "20",
pages = "534--45",
journal = "ADDICT BIOL",
issn = "1355-6215",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - No differences in ventral striatum responsivity between adolescents with a positive family history of alcoholism and controls

AU - Müller, Kathrin U

AU - Gan, Gabriela

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Büchel, Christian

AU - Conrod, Patricia

AU - Fauth-Bühler, Mira

AU - Flor, Herta

AU - Gallinat, Jürgen

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Lawrence, Claire

AU - Loth, Eva

AU - Mann, Karl

AU - Martinot, Jean-Luc

AU - Nees, Frauke

AU - Paus, Tomáš

AU - Pausova, Zdenka

AU - Rietschel, Marcella

AU - Ströhle, Andreas

AU - Struve, Maren

AU - Schumann, Gunter

AU - Smolka, Michael N

AU - IMAGEN Consortium

N1 - © 2014 Society for the Study of Addiction.

PY - 2014

Y1 - 2014

N2 - Individuals with alcohol-dependent parents show an elevated risk of developing alcohol-related problems themselves. Modulations of the mesolimbic reward circuit have been postulated as a pre-existing marker of alcoholism. We tested whether a positive family history of alcoholism is correlated with ventral striatum functionality during a reward task. All participants performed a modified version of the monetary incentive delay task while their brain responses were measured with functional magnetic resonance imaging. We compared 206 healthy adolescents (aged 13-15) who had any first- or second-degree relative with alcoholism to 206 matched controls with no biological relative with alcoholism. Reward anticipation as well as feedback of win recruited the ventral striatum in all participants, but adolescents with a positive family history of alcoholism did not differ from their matched peers. Also we did not find any correlation between family history density and reward anticipation or feedback of win. This finding of no differences did not change when we analyzed a subsample of 77 adolescents with at least one parent with alcohol use disorder and their matched controls. Because this result is in line with another study reporting no differences between children with alcohol-dependent parents and controls at young age, but contrasts with studies of older individuals, one might conclude that at younger age the effect of family history has not yet exerted its influence on the still developing mesolimbic reward circuit.

AB - Individuals with alcohol-dependent parents show an elevated risk of developing alcohol-related problems themselves. Modulations of the mesolimbic reward circuit have been postulated as a pre-existing marker of alcoholism. We tested whether a positive family history of alcoholism is correlated with ventral striatum functionality during a reward task. All participants performed a modified version of the monetary incentive delay task while their brain responses were measured with functional magnetic resonance imaging. We compared 206 healthy adolescents (aged 13-15) who had any first- or second-degree relative with alcoholism to 206 matched controls with no biological relative with alcoholism. Reward anticipation as well as feedback of win recruited the ventral striatum in all participants, but adolescents with a positive family history of alcoholism did not differ from their matched peers. Also we did not find any correlation between family history density and reward anticipation or feedback of win. This finding of no differences did not change when we analyzed a subsample of 77 adolescents with at least one parent with alcohol use disorder and their matched controls. Because this result is in line with another study reporting no differences between children with alcohol-dependent parents and controls at young age, but contrasts with studies of older individuals, one might conclude that at younger age the effect of family history has not yet exerted its influence on the still developing mesolimbic reward circuit.

U2 - 10.1111/adb.12136

DO - 10.1111/adb.12136

M3 - SCORING: Journal article

C2 - 24903627

VL - 20

SP - 534

EP - 545

JO - ADDICT BIOL

JF - ADDICT BIOL

SN - 1355-6215

IS - 3

ER -