PortalPublikationenNo association of the variant rs11887120 in DNMT3A with cogn...

No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment

Standard

No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment. / Bey, Katharina; Wolfsgruber, Steffen; Karaca, Ilker; Wagner, Holger; Lardenoije, Roy; Becker, Julian; Milz, Esther; Kornhuber, Johannes; Peters, Oliver; Frölich, Lutz; Hüll, Michael; Rüther, Eckart; Wiltfang, Jens; Riedel-Heller, Steffi; Scherer, Martin; Jessen, Frank; Maier, Wolfgang; van den Hove, Daniel L; Rutten, Bart Pf; Wagner, Michael; Ramirez, Alfredo.

in: EPIGENOMICS-UK, Jahrgang 8, Nr. 5, 05.2016, S. 593-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bey, K, Wolfsgruber, S, Karaca, I, Wagner, H, Lardenoije, R, Becker, J, Milz, E, Kornhuber, J, Peters, O, Frölich, L, Hüll, M, Rüther, E, Wiltfang, J, Riedel-Heller, S, Scherer, M, Jessen, F, Maier, W, van den Hove, DL, Rutten, BP, Wagner, M & Ramirez, A 2016, 'No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment', EPIGENOMICS-UK, Jg. 8, Nr. 5, S. 593-8. https://doi.org/10.2217/epi-2015-0014

APA

Bey, K., Wolfsgruber, S., Karaca, I., Wagner, H., Lardenoije, R., Becker, J., Milz, E., Kornhuber, J., Peters, O., Frölich, L., Hüll, M., Rüther, E., Wiltfang, J., Riedel-Heller, S., Scherer, M., Jessen, F., Maier, W., van den Hove, D. L., Rutten, B. P., ... Ramirez, A. (2016). No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment. EPIGENOMICS-UK, 8(5), 593-8. https://doi.org/10.2217/epi-2015-0014

Vancouver

Bey K, Wolfsgruber S, Karaca I, Wagner H, Lardenoije R, Becker J et al. No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment. EPIGENOMICS-UK. 2016 Mai;8(5):593-8. https://doi.org/10.2217/epi-2015-0014

Bibtex

@article{040afe95b9ed43b6b8d299c3626b93bc,
title = "No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment",
abstract = "Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI.",
keywords = "Journal Article",
author = "Katharina Bey and Steffen Wolfsgruber and Ilker Karaca and Holger Wagner and Roy Lardenoije and Julian Becker and Esther Milz and Johannes Kornhuber and Oliver Peters and Lutz Fr{\"o}lich and Michael H{\"u}ll and Eckart R{\"u}ther and Jens Wiltfang and Steffi Riedel-Heller and Martin Scherer and Frank Jessen and Wolfgang Maier and {van den Hove}, {Daniel L} and Rutten, {Bart Pf} and Michael Wagner and Alfredo Ramirez",
year = "2016",
month = may,
doi = "10.2217/epi-2015-0014",
language = "English",
volume = "8",
pages = "593--8",
journal = "EPIGENOMICS-UK",
issn = "1750-1911",
publisher = "Future Medicine Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - No association of the variant rs11887120 in DNMT3A with cognitive decline in individuals with mild cognitive impairment

AU - Bey, Katharina

AU - Wolfsgruber, Steffen

AU - Karaca, Ilker

AU - Wagner, Holger

AU - Lardenoije, Roy

AU - Becker, Julian

AU - Milz, Esther

AU - Kornhuber, Johannes

AU - Peters, Oliver

AU - Frölich, Lutz

AU - Hüll, Michael

AU - Rüther, Eckart

AU - Wiltfang, Jens

AU - Riedel-Heller, Steffi

AU - Scherer, Martin

AU - Jessen, Frank

AU - Maier, Wolfgang

AU - van den Hove, Daniel L

AU - Rutten, Bart Pf

AU - Wagner, Michael

AU - Ramirez, Alfredo

PY - 2016/5

Y1 - 2016/5

N2 - Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI.

AB - Alterations in DNA methylation have been associated with cognitive decline and Alzheimer's disease. A recent study of mild cognitive impairment (MCI) reported a significant association between annual decline in cognitive function and the rs11887120 SNP located in DNMT3A, a gene implicated in DNA methylation. Here, we aimed to replicate this finding in two independent MCI cohorts (n = 1024); however, no significant association was observed in either cohort or the pooled dataset. In stratified analyses for conversion to Alzheimer's disease status, no association between rs11887120 and cognitive decline was observed in either converters or nonconverters. In conclusion, our analyses provide no support for the hypothesis that genetic variants in DNMT3A are implicated in cognitive performance decline in individuals with MCI.

KW - Journal Article

U2 - 10.2217/epi-2015-0014

DO - 10.2217/epi-2015-0014

M3 - SCORING: Journal article

C2 - 27092400

VL - 8

SP - 593

EP - 598

JO - EPIGENOMICS-UK

JF - EPIGENOMICS-UK

SN - 1750-1911

IS - 5

ER -