No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning.
Standard
No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning. / Freundlieb, Nils; Philipp, Stephan; Schneider, Susanne A; Brüggemann, Norbert; Klein, Christine; Gerloff, Christian; Hummel, Friedhelm.
in: PLOS ONE, Jahrgang 7, Nr. 11, 11, 2012, S. 48327.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - No association of the BDNF val66met polymorphism with implicit associative vocabulary and motor learning.
AU - Freundlieb, Nils
AU - Philipp, Stephan
AU - Schneider, Susanne A
AU - Brüggemann, Norbert
AU - Klein, Christine
AU - Gerloff, Christian
AU - Hummel, Friedhelm
PY - 2012
Y1 - 2012
N2 - Brain-derived neurotrophic factor (BDNF) has been suggested to play a major role in plasticity, neurogenesis and learning in the adult brain. The BDNF gene contains a common val66met polymorphism associated with decreased activity-dependent excretion of BDNF and a potential influence on behaviour, more specifically, on motor learning. The objective of this study was to determine the influence of the BDNF val66met polymorphism on short-term implicit associative learning and whether its influence is cognitive domain-specific (motor vs. language). A sample of 38 young healthy participants was genotyped, screened for background and neuropsychological differences, and tested with two associative implicit learning paradigms in two different cognitive domains, i.e., motor and vocabulary learning. Subjects performed the serial reaction time task (SRTT) to determine implicit motor learning and a recently established associative vocabulary learning task (AVL) for implicit learning of action and object words. To determine the influence of the BDNF polymorphism on domain-specific implicit learning, behavioural improvements in the two tasks were compared between val/val (n?=?22) and met carriers (val/met: n?=?15 and met/met: n?=?1). There was no evidence for an impact of the BDNF val66met polymorphism on the behavioural outcome in implicit short-term learning paradigms in young healthy subjects. Whether this polymorphism plays a relevant role in long-term training paradigms or in subjects with impaired neuronal plasticity or reduced learning capacity, such as aged individuals, demented patients or patients with brain lesions, has to be determined in future studies.
AB - Brain-derived neurotrophic factor (BDNF) has been suggested to play a major role in plasticity, neurogenesis and learning in the adult brain. The BDNF gene contains a common val66met polymorphism associated with decreased activity-dependent excretion of BDNF and a potential influence on behaviour, more specifically, on motor learning. The objective of this study was to determine the influence of the BDNF val66met polymorphism on short-term implicit associative learning and whether its influence is cognitive domain-specific (motor vs. language). A sample of 38 young healthy participants was genotyped, screened for background and neuropsychological differences, and tested with two associative implicit learning paradigms in two different cognitive domains, i.e., motor and vocabulary learning. Subjects performed the serial reaction time task (SRTT) to determine implicit motor learning and a recently established associative vocabulary learning task (AVL) for implicit learning of action and object words. To determine the influence of the BDNF polymorphism on domain-specific implicit learning, behavioural improvements in the two tasks were compared between val/val (n?=?22) and met carriers (val/met: n?=?15 and met/met: n?=?1). There was no evidence for an impact of the BDNF val66met polymorphism on the behavioural outcome in implicit short-term learning paradigms in young healthy subjects. Whether this polymorphism plays a relevant role in long-term training paradigms or in subjects with impaired neuronal plasticity or reduced learning capacity, such as aged individuals, demented patients or patients with brain lesions, has to be determined in future studies.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Young Adult
KW - Genotype
KW - Amino Acid Substitution
KW - Reaction Time
KW - Psychomotor Performance/physiology
KW - Polymorphism, Genetic
KW - Learning/physiology
KW - Brain-Derived Neurotrophic Factor/genetics
KW - Verbal Learning/physiology
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Young Adult
KW - Genotype
KW - Amino Acid Substitution
KW - Reaction Time
KW - Psychomotor Performance/physiology
KW - Polymorphism, Genetic
KW - Learning/physiology
KW - Brain-Derived Neurotrophic Factor/genetics
KW - Verbal Learning/physiology
U2 - 10.1371/journal.pone.0048327
DO - 10.1371/journal.pone.0048327
M3 - SCORING: Journal article
VL - 7
SP - 48327
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 11
M1 - 11
ER -
