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NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation

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NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation. / Neumann, Katrin; Schiller, Birgit; Tiegs, Gisa.

in: INT J MOL SCI, Jahrgang 19, Nr. 9, 12.09.2018, S. 2732.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Neumann, K, Schiller, B & Tiegs, G 2018, 'NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation', INT J MOL SCI, Jg. 19, Nr. 9, S. 2732. https://doi.org/10.3390/ijms19092732

APA

Neumann, K., Schiller, B., & Tiegs, G. (2018). NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation. INT J MOL SCI, 19(9), 2732. https://doi.org/10.3390/ijms19092732

Vancouver

Neumann K, Schiller B, Tiegs G. NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation. INT J MOL SCI. 2018 Sep 12;19(9):2732. https://doi.org/10.3390/ijms19092732

Bibtex

@article{a291abdd22b3498b9b6da8b7f01dca66,
title = "NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation",
abstract = "In sterile liver inflammation, danger signals are released in response to tissue injury to alert the immune system; e.g., by activation of the NLRP3 inflammasome. Recently, IL-33 has been identified as a novel type of danger signal or {"}alarmin{"}, which is released from damaged and necrotic cells. IL-33 is a pleiotropic cytokine that targets a broad range of immune cells and exhibits pro- and anti-inflammatory properties dependent on the disease. This review summarizes the immunomodulatory roles of the NLRP3 inflammasome and IL-33 in sterile liver inflammation and highlights potential therapeutic strategies targeting these pathways in liver disease.",
keywords = "Animals, Hepatitis, Autoimmune, Humans, Inflammasomes, Interleukin-33, Liver, Liver Diseases, Alcoholic, NLR Family, Pyrin Domain-Containing 3 Protein, Non-alcoholic Fatty Liver Disease, Journal Article, Review",
author = "Katrin Neumann and Birgit Schiller and Gisa Tiegs",
year = "2018",
month = sep,
day = "12",
doi = "10.3390/ijms19092732",
language = "English",
volume = "19",
pages = "2732",
journal = "INT J MOL SCI",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "9",

}

RIS

TY - JOUR

T1 - NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation

AU - Neumann, Katrin

AU - Schiller, Birgit

AU - Tiegs, Gisa

PY - 2018/9/12

Y1 - 2018/9/12

N2 - In sterile liver inflammation, danger signals are released in response to tissue injury to alert the immune system; e.g., by activation of the NLRP3 inflammasome. Recently, IL-33 has been identified as a novel type of danger signal or "alarmin", which is released from damaged and necrotic cells. IL-33 is a pleiotropic cytokine that targets a broad range of immune cells and exhibits pro- and anti-inflammatory properties dependent on the disease. This review summarizes the immunomodulatory roles of the NLRP3 inflammasome and IL-33 in sterile liver inflammation and highlights potential therapeutic strategies targeting these pathways in liver disease.

AB - In sterile liver inflammation, danger signals are released in response to tissue injury to alert the immune system; e.g., by activation of the NLRP3 inflammasome. Recently, IL-33 has been identified as a novel type of danger signal or "alarmin", which is released from damaged and necrotic cells. IL-33 is a pleiotropic cytokine that targets a broad range of immune cells and exhibits pro- and anti-inflammatory properties dependent on the disease. This review summarizes the immunomodulatory roles of the NLRP3 inflammasome and IL-33 in sterile liver inflammation and highlights potential therapeutic strategies targeting these pathways in liver disease.

KW - Animals

KW - Hepatitis, Autoimmune

KW - Humans

KW - Inflammasomes

KW - Interleukin-33

KW - Liver

KW - Liver Diseases, Alcoholic

KW - NLR Family, Pyrin Domain-Containing 3 Protein

KW - Non-alcoholic Fatty Liver Disease

KW - Journal Article

KW - Review

U2 - 10.3390/ijms19092732

DO - 10.3390/ijms19092732

M3 - SCORING: Review article

C2 - 30213101

VL - 19

SP - 2732

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 9

ER -