NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells
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NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells. / Padoan, Benedetta; Casar, Christian; Krause, Jenny; Schultheiss, Christoph; Baumdick, Martin E; Niehrs, Annika; Zecher, Britta F; Pujantell, Maria; Yuki, Yuko; Martin, Maureen; Remmerswaal, Ester B M; Dekker, Tamara; van der Bom-Baylon, Nelly D; Noble, Janelle A; Carrington, Mary; Bemelman, Frederike J; van Lier, Rene A W; Binder, Mascha; Gagliani, Nicola; Bunders, Madeleine J; Altfeld, Marcus.
in: CELL REP, Jahrgang 43, Nr. 4, 23.04.2024, S. 114089.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells
AU - Padoan, Benedetta
AU - Casar, Christian
AU - Krause, Jenny
AU - Schultheiss, Christoph
AU - Baumdick, Martin E
AU - Niehrs, Annika
AU - Zecher, Britta F
AU - Pujantell, Maria
AU - Yuki, Yuko
AU - Martin, Maureen
AU - Remmerswaal, Ester B M
AU - Dekker, Tamara
AU - van der Bom-Baylon, Nelly D
AU - Noble, Janelle A
AU - Carrington, Mary
AU - Bemelman, Frederike J
AU - van Lier, Rene A W
AU - Binder, Mascha
AU - Gagliani, Nicola
AU - Bunders, Madeleine J
AU - Altfeld, Marcus
N1 - Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
PY - 2024/4/23
Y1 - 2024/4/23
N2 - Although natural killer (NK) cells are recognized for their modulation of immune responses, the mechanisms by which human NK cells mediate immune regulation are unclear. Here, we report that expression of human leukocyte antigen (HLA)-DP, a ligand for the activating NK cell receptor NKp44, is significantly upregulated on CD8+ effector T cells, in particular in human cytomegalovirus (HCMV)+ individuals. HLA-DP+ CD8+ T cells expressing NKp44-binding HLA-DP antigens activate NKp44+ NK cells, while HLA-DP+ CD8+ T cells not expressing NKp44-binding HLA-DP antigens do not. In line with this, frequencies of HLA-DP+ CD8+ T cells are increased in individuals not encoding for NKp44-binding HLA-DP haplotypes, and contain hyper-expanded CD8+ T cell clones, compared to individuals expressing NKp44-binding HLA-DP molecules. These findings identify a molecular interaction facilitating the HLA-DP haplotype-specific editing of HLA-DP+ CD8+ T cell effector populations by NKp44+ NK cells and preventing the generation of hyper-expanded T cell clones, which have been suggested to have increased potential for autoimmunity.
AB - Although natural killer (NK) cells are recognized for their modulation of immune responses, the mechanisms by which human NK cells mediate immune regulation are unclear. Here, we report that expression of human leukocyte antigen (HLA)-DP, a ligand for the activating NK cell receptor NKp44, is significantly upregulated on CD8+ effector T cells, in particular in human cytomegalovirus (HCMV)+ individuals. HLA-DP+ CD8+ T cells expressing NKp44-binding HLA-DP antigens activate NKp44+ NK cells, while HLA-DP+ CD8+ T cells not expressing NKp44-binding HLA-DP antigens do not. In line with this, frequencies of HLA-DP+ CD8+ T cells are increased in individuals not encoding for NKp44-binding HLA-DP haplotypes, and contain hyper-expanded CD8+ T cell clones, compared to individuals expressing NKp44-binding HLA-DP molecules. These findings identify a molecular interaction facilitating the HLA-DP haplotype-specific editing of HLA-DP+ CD8+ T cell effector populations by NKp44+ NK cells and preventing the generation of hyper-expanded T cell clones, which have been suggested to have increased potential for autoimmunity.
U2 - 10.1016/j.celrep.2024.114089
DO - 10.1016/j.celrep.2024.114089
M3 - SCORING: Journal article
C2 - 38615318
VL - 43
SP - 114089
JO - CELL REP
JF - CELL REP
SN - 2211-1247
IS - 4
ER -
