New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities
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New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities. / Tabakmakher, Kseniya M; Makarieva, Tatyana N; Denisenko, Vladimir A; Popov, Roman S; Dmitrenok, Pavel S; Dyshlovoy, Sergey A; Grebnev, Boris B; Bokemeyer, Carsten; von Amsberg, Gunhild; Cuong, Nguyen X.
in: MAR DRUGS, Jahrgang 17, Nr. 8, 27.07.2019.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities
AU - Tabakmakher, Kseniya M
AU - Makarieva, Tatyana N
AU - Denisenko, Vladimir A
AU - Popov, Roman S
AU - Dmitrenok, Pavel S
AU - Dyshlovoy, Sergey A
AU - Grebnev, Boris B
AU - Bokemeyer, Carsten
AU - von Amsberg, Gunhild
AU - Cuong, Nguyen X
PY - 2019/7/27
Y1 - 2019/7/27
N2 - Seven new unusual polysulfated steroids-topsentiasterol sulfate G (1), topsentiasterol sulfate I (2), topsentiasterol sulfate H (3), bromotopsentiasterol sulfate D (4), dichlorotopsentiasterol sulfate D (8), bromochlorotopsentiasterol sulfate D (9), and 4β-hydroxyhalistanol sulfate C (10), as well as three previously described-topsentiasterol sulfate D (7), chlorotopsentiasterol sulfate D (5) and iodotopsentiasterol sulfate D (6) have been isolated from the marine sponge Halichondria vansoesti. Structures of these compounds were determined by detailed analysis of 1D- and 2D-NMR and HRESIMS data, as well as chemical transformations. The effects of the compounds on human prostate cancer cells PC-3 and 22Rv1 were investigated.
AB - Seven new unusual polysulfated steroids-topsentiasterol sulfate G (1), topsentiasterol sulfate I (2), topsentiasterol sulfate H (3), bromotopsentiasterol sulfate D (4), dichlorotopsentiasterol sulfate D (8), bromochlorotopsentiasterol sulfate D (9), and 4β-hydroxyhalistanol sulfate C (10), as well as three previously described-topsentiasterol sulfate D (7), chlorotopsentiasterol sulfate D (5) and iodotopsentiasterol sulfate D (6) have been isolated from the marine sponge Halichondria vansoesti. Structures of these compounds were determined by detailed analysis of 1D- and 2D-NMR and HRESIMS data, as well as chemical transformations. The effects of the compounds on human prostate cancer cells PC-3 and 22Rv1 were investigated.
U2 - 10.3390/md17080445
DO - 10.3390/md17080445
M3 - SCORING: Journal article
C2 - 31357591
VL - 17
JO - MAR DRUGS
JF - MAR DRUGS
SN - 1660-3397
IS - 8
ER -