New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities

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New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities. / Tabakmakher, Kseniya M; Makarieva, Tatyana N; Denisenko, Vladimir A; Popov, Roman S; Dmitrenok, Pavel S; Dyshlovoy, Sergey A; Grebnev, Boris B; Bokemeyer, Carsten; von Amsberg, Gunhild; Cuong, Nguyen X.

in: MAR DRUGS, Jahrgang 17, Nr. 8, 27.07.2019.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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@article{74601d3019aa4c4f81dc7c6eced631a5,
title = "New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities",
abstract = "Seven new unusual polysulfated steroids-topsentiasterol sulfate G (1), topsentiasterol sulfate I (2), topsentiasterol sulfate H (3), bromotopsentiasterol sulfate D (4), dichlorotopsentiasterol sulfate D (8), bromochlorotopsentiasterol sulfate D (9), and 4β-hydroxyhalistanol sulfate C (10), as well as three previously described-topsentiasterol sulfate D (7), chlorotopsentiasterol sulfate D (5) and iodotopsentiasterol sulfate D (6) have been isolated from the marine sponge Halichondria vansoesti. Structures of these compounds were determined by detailed analysis of 1D- and 2D-NMR and HRESIMS data, as well as chemical transformations. The effects of the compounds on human prostate cancer cells PC-3 and 22Rv1 were investigated.",
author = "Tabakmakher, {Kseniya M} and Makarieva, {Tatyana N} and Denisenko, {Vladimir A} and Popov, {Roman S} and Dmitrenok, {Pavel S} and Dyshlovoy, {Sergey A} and Grebnev, {Boris B} and Carsten Bokemeyer and {von Amsberg}, Gunhild and Cuong, {Nguyen X}",
year = "2019",
month = jul,
day = "27",
doi = "10.3390/md17080445",
language = "English",
volume = "17",
journal = "MAR DRUGS",
issn = "1660-3397",
publisher = "MDPI AG",
number = "8",

}

RIS

TY - JOUR

T1 - New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities

AU - Tabakmakher, Kseniya M

AU - Makarieva, Tatyana N

AU - Denisenko, Vladimir A

AU - Popov, Roman S

AU - Dmitrenok, Pavel S

AU - Dyshlovoy, Sergey A

AU - Grebnev, Boris B

AU - Bokemeyer, Carsten

AU - von Amsberg, Gunhild

AU - Cuong, Nguyen X

PY - 2019/7/27

Y1 - 2019/7/27

N2 - Seven new unusual polysulfated steroids-topsentiasterol sulfate G (1), topsentiasterol sulfate I (2), topsentiasterol sulfate H (3), bromotopsentiasterol sulfate D (4), dichlorotopsentiasterol sulfate D (8), bromochlorotopsentiasterol sulfate D (9), and 4β-hydroxyhalistanol sulfate C (10), as well as three previously described-topsentiasterol sulfate D (7), chlorotopsentiasterol sulfate D (5) and iodotopsentiasterol sulfate D (6) have been isolated from the marine sponge Halichondria vansoesti. Structures of these compounds were determined by detailed analysis of 1D- and 2D-NMR and HRESIMS data, as well as chemical transformations. The effects of the compounds on human prostate cancer cells PC-3 and 22Rv1 were investigated.

AB - Seven new unusual polysulfated steroids-topsentiasterol sulfate G (1), topsentiasterol sulfate I (2), topsentiasterol sulfate H (3), bromotopsentiasterol sulfate D (4), dichlorotopsentiasterol sulfate D (8), bromochlorotopsentiasterol sulfate D (9), and 4β-hydroxyhalistanol sulfate C (10), as well as three previously described-topsentiasterol sulfate D (7), chlorotopsentiasterol sulfate D (5) and iodotopsentiasterol sulfate D (6) have been isolated from the marine sponge Halichondria vansoesti. Structures of these compounds were determined by detailed analysis of 1D- and 2D-NMR and HRESIMS data, as well as chemical transformations. The effects of the compounds on human prostate cancer cells PC-3 and 22Rv1 were investigated.

U2 - 10.3390/md17080445

DO - 10.3390/md17080445

M3 - SCORING: Journal article

C2 - 31357591

VL - 17

JO - MAR DRUGS

JF - MAR DRUGS

SN - 1660-3397

IS - 8

ER -