New systemic agents for hepatocellular carcinoma: an update 2020

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New systemic agents for hepatocellular carcinoma: an update 2020. / von Felden, Johann.

in: CURR OPIN GASTROEN, Jahrgang 36, Nr. 3, 05.2020, S. 177-183.

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@article{dfd16dd11e604d9d84ae7596c3ea792f,
title = "New systemic agents for hepatocellular carcinoma: an update 2020",
abstract = "PURPOSE OF REVIEW: Despite major therapeutic improvements in most cancer entities, hepatocellular carcinoma (HCC) has remained a dismal disease. In fact, incidence and mortality are increasing in many parts of the world, including the United States. Given that a number of systemic agents has recently been tested positive in phase 3 clinical trials, the objective of this review is to summarize the current treatment landscape for advanced HCC.RECENT FINDINGS: Following the positive SHARP trial in 2008, sorafenib has been the only systemic agent for advanced HCC for almost a decade. However, in first line, lenvatinib was tested noninferior to sorafenib, and most recently, the combination of atezolizumab with bevacizumab was tested superior to sorafenib. In second line, regorafenib, cabozantinib, and ramucirumab (the latter for patients with AFP ≥400 ng/ml) have shown prolonged overall survival compared with placebo.SUMMARY: Systemic treatment options for advanced HCC have substantially increased over the past years. The combination of atezolizumab and bevacizumab will likely become the new standard of care as it is the first treatment to report improved overall survival compared with sorafenib and the first, and so far only, positive phase 3 clinical trial for an immune-checkpoint inhibitor-containing regimen in advanced HCC.",
author = "{von Felden}, Johann",
year = "2020",
month = may,
doi = "10.1097/MOG.0000000000000626",
language = "English",
volume = "36",
pages = "177--183",
journal = "CURR OPIN GASTROEN",
issn = "0267-1379",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - New systemic agents for hepatocellular carcinoma: an update 2020

AU - von Felden, Johann

PY - 2020/5

Y1 - 2020/5

N2 - PURPOSE OF REVIEW: Despite major therapeutic improvements in most cancer entities, hepatocellular carcinoma (HCC) has remained a dismal disease. In fact, incidence and mortality are increasing in many parts of the world, including the United States. Given that a number of systemic agents has recently been tested positive in phase 3 clinical trials, the objective of this review is to summarize the current treatment landscape for advanced HCC.RECENT FINDINGS: Following the positive SHARP trial in 2008, sorafenib has been the only systemic agent for advanced HCC for almost a decade. However, in first line, lenvatinib was tested noninferior to sorafenib, and most recently, the combination of atezolizumab with bevacizumab was tested superior to sorafenib. In second line, regorafenib, cabozantinib, and ramucirumab (the latter for patients with AFP ≥400 ng/ml) have shown prolonged overall survival compared with placebo.SUMMARY: Systemic treatment options for advanced HCC have substantially increased over the past years. The combination of atezolizumab and bevacizumab will likely become the new standard of care as it is the first treatment to report improved overall survival compared with sorafenib and the first, and so far only, positive phase 3 clinical trial for an immune-checkpoint inhibitor-containing regimen in advanced HCC.

AB - PURPOSE OF REVIEW: Despite major therapeutic improvements in most cancer entities, hepatocellular carcinoma (HCC) has remained a dismal disease. In fact, incidence and mortality are increasing in many parts of the world, including the United States. Given that a number of systemic agents has recently been tested positive in phase 3 clinical trials, the objective of this review is to summarize the current treatment landscape for advanced HCC.RECENT FINDINGS: Following the positive SHARP trial in 2008, sorafenib has been the only systemic agent for advanced HCC for almost a decade. However, in first line, lenvatinib was tested noninferior to sorafenib, and most recently, the combination of atezolizumab with bevacizumab was tested superior to sorafenib. In second line, regorafenib, cabozantinib, and ramucirumab (the latter for patients with AFP ≥400 ng/ml) have shown prolonged overall survival compared with placebo.SUMMARY: Systemic treatment options for advanced HCC have substantially increased over the past years. The combination of atezolizumab and bevacizumab will likely become the new standard of care as it is the first treatment to report improved overall survival compared with sorafenib and the first, and so far only, positive phase 3 clinical trial for an immune-checkpoint inhibitor-containing regimen in advanced HCC.

U2 - 10.1097/MOG.0000000000000626

DO - 10.1097/MOG.0000000000000626

M3 - SCORING: Review article

C2 - 32101985

VL - 36

SP - 177

EP - 183

JO - CURR OPIN GASTROEN

JF - CURR OPIN GASTROEN

SN - 0267-1379

IS - 3

ER -