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Neuroprotective actions of a histidine analogue in models of ischemic stroke.

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Neuroprotective actions of a histidine analogue in models of ischemic stroke. / Tang, Sung-Chun; Arumugam, Thiruma V; Cutler, Roy G; Jo, Dong-Gyu; Magnus, Tim; Chan, Sic L; Mughal, Mohamed R; Telljohann, Richard S; Nassar, Matthew; Ouyang, Xin; Calderan, Andrea; Ruzza, Paolo; Guiotto, Andrea; Mattson, Mark P.

in: J NEUROCHEM, Jahrgang 101, Nr. 3, 3, 2007, S. 729-736.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Tang, S-C, Arumugam, TV, Cutler, RG, Jo, D-G, Magnus, T, Chan, SL, Mughal, MR, Telljohann, RS, Nassar, M, Ouyang, X, Calderan, A, Ruzza, P, Guiotto, A & Mattson, MP 2007, 'Neuroprotective actions of a histidine analogue in models of ischemic stroke.', J NEUROCHEM, Jg. 101, Nr. 3, 3, S. 729-736. <http://www.ncbi.nlm.nih.gov/pubmed/17254011?dopt=Citation>

APA

Tang, S-C., Arumugam, T. V., Cutler, R. G., Jo, D-G., Magnus, T., Chan, S. L., Mughal, M. R., Telljohann, R. S., Nassar, M., Ouyang, X., Calderan, A., Ruzza, P., Guiotto, A., & Mattson, M. P. (2007). Neuroprotective actions of a histidine analogue in models of ischemic stroke. J NEUROCHEM, 101(3), 729-736. [3]. http://www.ncbi.nlm.nih.gov/pubmed/17254011?dopt=Citation

Vancouver

Tang S-C, Arumugam TV, Cutler RG, Jo D-G, Magnus T, Chan SL et al. Neuroprotective actions of a histidine analogue in models of ischemic stroke. J NEUROCHEM. 2007;101(3):729-736. 3.

Bibtex

@article{e6a04301701240f4acf32169b290205b,
title = "Neuroprotective actions of a histidine analogue in models of ischemic stroke.",
abstract = "Histidine is a naturally occurring amino acid with antioxidant properties, which is present in low amounts in tissues throughout the body. We recently synthesized and characterized histidine analogues related to the natural dipeptide carnosine, which selectively scavenge the toxic lipid peroxidation product 4-hydroxynonenal (HNE). We now report that the histidine analogue histidyl hydrazide is effective in reducing brain damage and improving functional outcome in a mouse model of focal ischemic stroke when administered intravenously at a dose of 20 mg/kg, either 30 min before or 60 min and 3 h after the onset of middle cerebral artery occlusion. The histidine analogue also protected cultured rat primary neurons against death induced by HNE, chemical hypoxia, glucose deprivation, and combined oxygen and glucose deprivation. The histidine analogue prevented neuronal apoptosis as indicated by decreased production of cleaved caspase-3 protein. These findings suggest a therapeutic potential for HNE-scavenging histidine analogues in the treatment of stroke and related neurodegenerative conditions.",
author = "Sung-Chun Tang and Arumugam, {Thiruma V} and Cutler, {Roy G} and Dong-Gyu Jo and Tim Magnus and Chan, {Sic L} and Mughal, {Mohamed R} and Telljohann, {Richard S} and Matthew Nassar and Xin Ouyang and Andrea Calderan and Paolo Ruzza and Andrea Guiotto and Mattson, {Mark P}",
year = "2007",
language = "Deutsch",
volume = "101",
pages = "729--736",
journal = "J NEUROCHEM",
issn = "0022-3042",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Neuroprotective actions of a histidine analogue in models of ischemic stroke.

AU - Tang, Sung-Chun

AU - Arumugam, Thiruma V

AU - Cutler, Roy G

AU - Jo, Dong-Gyu

AU - Magnus, Tim

AU - Chan, Sic L

AU - Mughal, Mohamed R

AU - Telljohann, Richard S

AU - Nassar, Matthew

AU - Ouyang, Xin

AU - Calderan, Andrea

AU - Ruzza, Paolo

AU - Guiotto, Andrea

AU - Mattson, Mark P

PY - 2007

Y1 - 2007

N2 - Histidine is a naturally occurring amino acid with antioxidant properties, which is present in low amounts in tissues throughout the body. We recently synthesized and characterized histidine analogues related to the natural dipeptide carnosine, which selectively scavenge the toxic lipid peroxidation product 4-hydroxynonenal (HNE). We now report that the histidine analogue histidyl hydrazide is effective in reducing brain damage and improving functional outcome in a mouse model of focal ischemic stroke when administered intravenously at a dose of 20 mg/kg, either 30 min before or 60 min and 3 h after the onset of middle cerebral artery occlusion. The histidine analogue also protected cultured rat primary neurons against death induced by HNE, chemical hypoxia, glucose deprivation, and combined oxygen and glucose deprivation. The histidine analogue prevented neuronal apoptosis as indicated by decreased production of cleaved caspase-3 protein. These findings suggest a therapeutic potential for HNE-scavenging histidine analogues in the treatment of stroke and related neurodegenerative conditions.

AB - Histidine is a naturally occurring amino acid with antioxidant properties, which is present in low amounts in tissues throughout the body. We recently synthesized and characterized histidine analogues related to the natural dipeptide carnosine, which selectively scavenge the toxic lipid peroxidation product 4-hydroxynonenal (HNE). We now report that the histidine analogue histidyl hydrazide is effective in reducing brain damage and improving functional outcome in a mouse model of focal ischemic stroke when administered intravenously at a dose of 20 mg/kg, either 30 min before or 60 min and 3 h after the onset of middle cerebral artery occlusion. The histidine analogue also protected cultured rat primary neurons against death induced by HNE, chemical hypoxia, glucose deprivation, and combined oxygen and glucose deprivation. The histidine analogue prevented neuronal apoptosis as indicated by decreased production of cleaved caspase-3 protein. These findings suggest a therapeutic potential for HNE-scavenging histidine analogues in the treatment of stroke and related neurodegenerative conditions.

M3 - SCORING: Zeitschriftenaufsatz

VL - 101

SP - 729

EP - 736

JO - J NEUROCHEM

JF - J NEUROCHEM

SN - 0022-3042

IS - 3

M1 - 3

ER -