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Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro.

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Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro. / Lange, Annika; Gustke, Heike; Glassmeier, Günter; Heine, Markus; Zangemeister-Wittke, Uwe; Schwarz, Jürgen; Schumacher, Udo; Lange, Tobias.

in: LUNG CANCER, Jahrgang 74, Nr. 2, 2, 2011, S. 178-187.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lange, A, Gustke, H, Glassmeier, G, Heine, M, Zangemeister-Wittke, U, Schwarz, J, Schumacher, U & Lange, T 2011, 'Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro.', LUNG CANCER, Jg. 74, Nr. 2, 2, S. 178-187. <http://www.ncbi.nlm.nih.gov/pubmed/21511354?dopt=Citation>

APA

Lange, A., Gustke, H., Glassmeier, G., Heine, M., Zangemeister-Wittke, U., Schwarz, J., Schumacher, U., & Lange, T. (2011). Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro. LUNG CANCER, 74(2), 178-187. [2]. http://www.ncbi.nlm.nih.gov/pubmed/21511354?dopt=Citation

Vancouver

Lange A, Gustke H, Glassmeier G, Heine M, Zangemeister-Wittke U, Schwarz J et al. Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro. LUNG CANCER. 2011;74(2):178-187. 2.

Bibtex

@article{59e7065daa904668af63af4e67651627,
title = "Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro.",
abstract = "Small cell lung cancer (SCLC) is one of the most aggressive malignancies implying a very poor prognosis for patients even under therapy. Since it is known that SCLC cells exhibit neurone-like characteristics, we investigated whether a neuronal induction medium (NID) consisting of indomethacin (200 ?M), 3-isobutyl-1-methylxanthine (IBMX, 500 ?M) and insulin (5 ?g/ml) induces neuronal differentiation and by this reduces malignancy of SCLC in vitro.",
keywords = "Humans, Cell Line, Tumor, Cell Differentiation/drug effects, 1-Methyl-3-isobutylxanthine/*pharmacology, Antigens, CD56/metabolism, Cell Growth Processes/drug effects, Cyclooxygenase 1/genetics/metabolism, Cyclooxygenase 2/genetics/metabolism, Indomethacin/*pharmacology, Lung Neoplasms/*drug therapy/pathology/physiopathology, Neural Cell Adhesion Molecule L1/metabolism, Neurons/*drug effects/metabolism/pathology, Small Cell Lung Carcinoma/*drug therapy/pathology/physiopathology, Sodium Channels/genetics/metabolism, Humans, Cell Line, Tumor, Cell Differentiation/drug effects, 1-Methyl-3-isobutylxanthine/*pharmacology, Antigens, CD56/metabolism, Cell Growth Processes/drug effects, Cyclooxygenase 1/genetics/metabolism, Cyclooxygenase 2/genetics/metabolism, Indomethacin/*pharmacology, Lung Neoplasms/*drug therapy/pathology/physiopathology, Neural Cell Adhesion Molecule L1/metabolism, Neurons/*drug effects/metabolism/pathology, Small Cell Lung Carcinoma/*drug therapy/pathology/physiopathology, Sodium Channels/genetics/metabolism",
author = "Annika Lange and Heike Gustke and G{\"u}nter Glassmeier and Markus Heine and Uwe Zangemeister-Wittke and J{\"u}rgen Schwarz and Udo Schumacher and Tobias Lange",
year = "2011",
language = "English",
volume = "74",
pages = "178--187",
journal = "LUNG CANCER",
issn = "0169-5002",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro.

AU - Lange, Annika

AU - Gustke, Heike

AU - Glassmeier, Günter

AU - Heine, Markus

AU - Zangemeister-Wittke, Uwe

AU - Schwarz, Jürgen

AU - Schumacher, Udo

AU - Lange, Tobias

PY - 2011

Y1 - 2011

N2 - Small cell lung cancer (SCLC) is one of the most aggressive malignancies implying a very poor prognosis for patients even under therapy. Since it is known that SCLC cells exhibit neurone-like characteristics, we investigated whether a neuronal induction medium (NID) consisting of indomethacin (200 ?M), 3-isobutyl-1-methylxanthine (IBMX, 500 ?M) and insulin (5 ?g/ml) induces neuronal differentiation and by this reduces malignancy of SCLC in vitro.

AB - Small cell lung cancer (SCLC) is one of the most aggressive malignancies implying a very poor prognosis for patients even under therapy. Since it is known that SCLC cells exhibit neurone-like characteristics, we investigated whether a neuronal induction medium (NID) consisting of indomethacin (200 ?M), 3-isobutyl-1-methylxanthine (IBMX, 500 ?M) and insulin (5 ?g/ml) induces neuronal differentiation and by this reduces malignancy of SCLC in vitro.

KW - Humans

KW - Cell Line, Tumor

KW - Cell Differentiation/drug effects

KW - 1-Methyl-3-isobutylxanthine/pharmacology

KW - Antigens, CD56/metabolism

KW - Cell Growth Processes/drug effects

KW - Cyclooxygenase 1/genetics/metabolism

KW - Cyclooxygenase 2/genetics/metabolism

KW - Indomethacin/pharmacology

KW - Lung Neoplasms/drug therapy/pathology/physiopathology

KW - Neural Cell Adhesion Molecule L1/metabolism

KW - Neurons/drug effects/metabolism/pathology

KW - Small Cell Lung Carcinoma/drug therapy/pathology/physiopathology

KW - Sodium Channels/genetics/metabolism

KW - Humans

KW - Cell Line, Tumor

KW - Cell Differentiation/drug effects

KW - 1-Methyl-3-isobutylxanthine/pharmacology

KW - Antigens, CD56/metabolism

KW - Cell Growth Processes/drug effects

KW - Cyclooxygenase 1/genetics/metabolism

KW - Cyclooxygenase 2/genetics/metabolism

KW - Indomethacin/pharmacology

KW - Lung Neoplasms/drug therapy/pathology/physiopathology

KW - Neural Cell Adhesion Molecule L1/metabolism

KW - Neurons/drug effects/metabolism/pathology

KW - Small Cell Lung Carcinoma/drug therapy/pathology/physiopathology

KW - Sodium Channels/genetics/metabolism

M3 - SCORING: Journal article

VL - 74

SP - 178

EP - 187

JO - LUNG CANCER

JF - LUNG CANCER

SN - 0169-5002

IS - 2

M1 - 2

ER -