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Neuronal calcium sensor-1 deletion in the mouse decreases motivation and dopamine release in the nucleus accumbens

Standard

Neuronal calcium sensor-1 deletion in the mouse decreases motivation and dopamine release in the nucleus accumbens. / Ng, Enoch; Varaschin, Rafael K; Su, Ping; Browne, Caleb J; Hermainski, Joanna; Le Foll, Bernard; Pongs, Olaf; Liu, Fang; Trudeau, Louis-Eric; Roder, John C; Wong, Albert H C.

in: BEHAV BRAIN RES, Jahrgang 301, 15.03.2016, S. 213-25.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ng, E, Varaschin, RK, Su, P, Browne, CJ, Hermainski, J, Le Foll, B, Pongs, O, Liu, F, Trudeau, L-E, Roder, JC & Wong, AHC 2016, 'Neuronal calcium sensor-1 deletion in the mouse decreases motivation and dopamine release in the nucleus accumbens', BEHAV BRAIN RES, Jg. 301, S. 213-25. https://doi.org/10.1016/j.bbr.2015.12.037

APA

Ng, E., Varaschin, R. K., Su, P., Browne, C. J., Hermainski, J., Le Foll, B., Pongs, O., Liu, F., Trudeau, L-E., Roder, J. C., & Wong, A. H. C. (2016). Neuronal calcium sensor-1 deletion in the mouse decreases motivation and dopamine release in the nucleus accumbens. BEHAV BRAIN RES, 301, 213-25. https://doi.org/10.1016/j.bbr.2015.12.037

Vancouver

Ng E, Varaschin RK, Su P, Browne CJ, Hermainski J, Le Foll B et al. Neuronal calcium sensor-1 deletion in the mouse decreases motivation and dopamine release in the nucleus accumbens. BEHAV BRAIN RES. 2016 Mär 15;301:213-25. https://doi.org/10.1016/j.bbr.2015.12.037

Bibtex

@article{4624e5d885c04a5496996135bc5d6c0c,
title = "Neuronal calcium sensor-1 deletion in the mouse decreases motivation and dopamine release in the nucleus accumbens",
abstract = "Calcium sensors detect intracellular calcium changes and interact with downstream targets to regulate many functions. Neuronal Calcium Sensor-1 (NCS-1) or Frequenin is widely expressed in the nervous system, and involved in neurotransmission, synaptic plasticity and learning. NCS-1 interacts with and regulates dopamine D2 receptor (D2R) internalization and is implicated in disorders like schizophrenia and substance abuse. However, the role of NCS-1 in behaviors dependent on dopamine signaling in the striatum, where D2R is most highly expressed, is unknown. We show that Ncs-1 deletion in the mouse decreases willingness to work for food. Moreover, Ncs-1 knockout mice have significantly lower activity-dependent dopamine release in the nucleus accumbens core in acute slice recordings. In contrast, food preference, responding for conditioned reinforcement, ability to represent changes in reward value, and locomotor response to amphetamine are not impaired. These studies identify novel roles for NCS-1 in regulating activity-dependent striatal dopamine release and aspects of motivated behavior.",
keywords = "Amphetamine, Animals, Central Nervous System Stimulants, Conditioning, Classical, Dopamine, Feeding Behavior, Food Preferences, Locomotion, Male, Mice, Inbred C57BL, Mice, Knockout, Motivation, Motor Activity, Neuronal Calcium-Sensor Proteins, Neuropeptides, Nucleus Accumbens, Satiety Response, Tissue Culture Techniques, Journal Article, Research Support, Non-U.S. Gov't",
author = "Enoch Ng and Varaschin, {Rafael K} and Ping Su and Browne, {Caleb J} and Joanna Hermainski and {Le Foll}, Bernard and Olaf Pongs and Fang Liu and Louis-Eric Trudeau and Roder, {John C} and Wong, {Albert H C}",
note = "Copyright {\textcopyright} 2015 Elsevier B.V. All rights reserved.",
year = "2016",
month = mar,
day = "15",
doi = "10.1016/j.bbr.2015.12.037",
language = "English",
volume = "301",
pages = "213--25",
journal = "BEHAV BRAIN RES",
issn = "0166-4328",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Neuronal calcium sensor-1 deletion in the mouse decreases motivation and dopamine release in the nucleus accumbens

AU - Ng, Enoch

AU - Varaschin, Rafael K

AU - Su, Ping

AU - Browne, Caleb J

AU - Hermainski, Joanna

AU - Le Foll, Bernard

AU - Pongs, Olaf

AU - Liu, Fang

AU - Trudeau, Louis-Eric

AU - Roder, John C

AU - Wong, Albert H C

N1 - Copyright © 2015 Elsevier B.V. All rights reserved.

PY - 2016/3/15

Y1 - 2016/3/15

N2 - Calcium sensors detect intracellular calcium changes and interact with downstream targets to regulate many functions. Neuronal Calcium Sensor-1 (NCS-1) or Frequenin is widely expressed in the nervous system, and involved in neurotransmission, synaptic plasticity and learning. NCS-1 interacts with and regulates dopamine D2 receptor (D2R) internalization and is implicated in disorders like schizophrenia and substance abuse. However, the role of NCS-1 in behaviors dependent on dopamine signaling in the striatum, where D2R is most highly expressed, is unknown. We show that Ncs-1 deletion in the mouse decreases willingness to work for food. Moreover, Ncs-1 knockout mice have significantly lower activity-dependent dopamine release in the nucleus accumbens core in acute slice recordings. In contrast, food preference, responding for conditioned reinforcement, ability to represent changes in reward value, and locomotor response to amphetamine are not impaired. These studies identify novel roles for NCS-1 in regulating activity-dependent striatal dopamine release and aspects of motivated behavior.

AB - Calcium sensors detect intracellular calcium changes and interact with downstream targets to regulate many functions. Neuronal Calcium Sensor-1 (NCS-1) or Frequenin is widely expressed in the nervous system, and involved in neurotransmission, synaptic plasticity and learning. NCS-1 interacts with and regulates dopamine D2 receptor (D2R) internalization and is implicated in disorders like schizophrenia and substance abuse. However, the role of NCS-1 in behaviors dependent on dopamine signaling in the striatum, where D2R is most highly expressed, is unknown. We show that Ncs-1 deletion in the mouse decreases willingness to work for food. Moreover, Ncs-1 knockout mice have significantly lower activity-dependent dopamine release in the nucleus accumbens core in acute slice recordings. In contrast, food preference, responding for conditioned reinforcement, ability to represent changes in reward value, and locomotor response to amphetamine are not impaired. These studies identify novel roles for NCS-1 in regulating activity-dependent striatal dopamine release and aspects of motivated behavior.

KW - Amphetamine

KW - Animals

KW - Central Nervous System Stimulants

KW - Conditioning, Classical

KW - Dopamine

KW - Feeding Behavior

KW - Food Preferences

KW - Locomotion

KW - Male

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Motivation

KW - Motor Activity

KW - Neuronal Calcium-Sensor Proteins

KW - Neuropeptides

KW - Nucleus Accumbens

KW - Satiety Response

KW - Tissue Culture Techniques

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.bbr.2015.12.037

DO - 10.1016/j.bbr.2015.12.037

M3 - SCORING: Journal article

C2 - 26738968

VL - 301

SP - 213

EP - 225

JO - BEHAV BRAIN RES

JF - BEHAV BRAIN RES

SN - 0166-4328

ER -