Neurocognitive impairment does not predict treatment outcome in obsessive-compulsive disorder.
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Neurocognitive impairment does not predict treatment outcome in obsessive-compulsive disorder. / Moritz, Steffen; Kloss, Martin; Jacobsen, Dirk; Fricke, Susanne; Cutler, Carrie; Brassen, Stefanie; Hand, Iver.
in: BEHAV RES THER, Jahrgang 43, Nr. 6, 6, 2005, S. 811-819.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Neurocognitive impairment does not predict treatment outcome in obsessive-compulsive disorder.
AU - Moritz, Steffen
AU - Kloss, Martin
AU - Jacobsen, Dirk
AU - Fricke, Susanne
AU - Cutler, Carrie
AU - Brassen, Stefanie
AU - Hand, Iver
PY - 2005
Y1 - 2005
N2 - There is conflicting evidence pertaining to whether or not neurocognitive task performance at baseline predicts treatment response in obsessive-compulsive disorder (OCD). In the present study, we administered a set of executive neurocognitive tests with a putative sensitivity for treatment outcome to a sample of 138 OCD patients. Additionally, subjective neurocognitive dysfunction was determined via a questionnaire. All patients participated in a cognitive-behavioural treatment program (CBT). Results showed that responders (n = 73) did not differ from non-responders (n = 65) on any of the parameters except for decreased performance on the delayed alternation test (p <.1, effect size: .61). A subsidiary analysis revealed that slowing on the Trail-Making Test A and an enhanced rate of perserveration errors on the Wisconsin Card Sorting Test predicted poor outcome for the treatment of compulsions. It is concluded that neurocognitive impairment does not represent a reliable early warning sign for non-response to CBT.
AB - There is conflicting evidence pertaining to whether or not neurocognitive task performance at baseline predicts treatment response in obsessive-compulsive disorder (OCD). In the present study, we administered a set of executive neurocognitive tests with a putative sensitivity for treatment outcome to a sample of 138 OCD patients. Additionally, subjective neurocognitive dysfunction was determined via a questionnaire. All patients participated in a cognitive-behavioural treatment program (CBT). Results showed that responders (n = 73) did not differ from non-responders (n = 65) on any of the parameters except for decreased performance on the delayed alternation test (p <.1, effect size: .61). A subsidiary analysis revealed that slowing on the Trail-Making Test A and an enhanced rate of perserveration errors on the Wisconsin Card Sorting Test predicted poor outcome for the treatment of compulsions. It is concluded that neurocognitive impairment does not represent a reliable early warning sign for non-response to CBT.
M3 - SCORING: Zeitschriftenaufsatz
VL - 43
SP - 811
EP - 819
JO - BEHAV RES THER
JF - BEHAV RES THER
SN - 0005-7967
IS - 6
M1 - 6
ER -
