Neurochemical modulation of repetition suppression and novelty signals in the human brain
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Neurochemical modulation of repetition suppression and novelty signals in the human brain. / Bunzeck, Nico; Thiel, Christiane.
in: CORTEX, Jahrgang 80, 01.07.2016, S. 161-73.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Neurochemical modulation of repetition suppression and novelty signals in the human brain
AU - Bunzeck, Nico
AU - Thiel, Christiane
N1 - Copyright © 2015. Published by Elsevier Ltd.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - The repeated processing of a sensory stimulus, such as a picture or sound, leads to a decrement in response in neurons that fired to the initial presentation. These effects are well known from single cell recordings in the inferior temporal cortex in monkeys, and functional neuroimaging in humans on large-scale neural activity could show similar effects in extrastriate, frontal and medial temporal lobe (MTL) regions. The role of specific neurotransmitters in repeated processing of information is, however, less clear. In the first part of this article, we will introduce the two concepts of repetition suppression and novelty signals, which is followed by a brief overview of pharmacological neuroimaging in humans. We will then summarize human studies suggesting that gamma-aminobutyric-acid (GABA) and acetylcholine (ACh) play an important role in modulating behavioral priming and associated repetition suppression in extrastriate and frontal brain regions. Finally, we review studies on neural novelty signals in the dopaminergic mesolimbic system, and conclude that dopamine (DA) regulates the temporal aspects of novelty processing and closely relates to long-term memory encoding rather than behavioral priming. As such, this review describes differential roles of GABA, ACh and DA in repeated stimulus processing, and further suggests that repetition suppression and neural novelty signals may not be two sides of the same coin but rather independent processes.
AB - The repeated processing of a sensory stimulus, such as a picture or sound, leads to a decrement in response in neurons that fired to the initial presentation. These effects are well known from single cell recordings in the inferior temporal cortex in monkeys, and functional neuroimaging in humans on large-scale neural activity could show similar effects in extrastriate, frontal and medial temporal lobe (MTL) regions. The role of specific neurotransmitters in repeated processing of information is, however, less clear. In the first part of this article, we will introduce the two concepts of repetition suppression and novelty signals, which is followed by a brief overview of pharmacological neuroimaging in humans. We will then summarize human studies suggesting that gamma-aminobutyric-acid (GABA) and acetylcholine (ACh) play an important role in modulating behavioral priming and associated repetition suppression in extrastriate and frontal brain regions. Finally, we review studies on neural novelty signals in the dopaminergic mesolimbic system, and conclude that dopamine (DA) regulates the temporal aspects of novelty processing and closely relates to long-term memory encoding rather than behavioral priming. As such, this review describes differential roles of GABA, ACh and DA in repeated stimulus processing, and further suggests that repetition suppression and neural novelty signals may not be two sides of the same coin but rather independent processes.
U2 - 10.1016/j.cortex.2015.10.013
DO - 10.1016/j.cortex.2015.10.013
M3 - SCORING: Journal article
C2 - 26625882
VL - 80
SP - 161
EP - 173
JO - CORTEX
JF - CORTEX
SN - 0010-9452
ER -