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Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha.

Standard

Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha. / Ye, Haihong; Tan, Yen Ling Jessie; Ponniah, Sathivel; Takeda, Yasuo; Wang, Shi-Qiang; Schachner, Melitta; Watanabe, Kazutada; Pallen, Catherine J; Xiao, Zhi-Cheng.

in: EMBO J, Jahrgang 27, Nr. 1, 1, 2008, S. 188-200.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ye, H, Tan, YLJ, Ponniah, S, Takeda, Y, Wang, S-Q, Schachner, M, Watanabe, K, Pallen, CJ & Xiao, Z-C 2008, 'Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha.', EMBO J, Jg. 27, Nr. 1, 1, S. 188-200. <http://www.ncbi.nlm.nih.gov/pubmed/18046458?dopt=Citation>

APA

Ye, H., Tan, Y. L. J., Ponniah, S., Takeda, Y., Wang, S-Q., Schachner, M., Watanabe, K., Pallen, C. J., & Xiao, Z-C. (2008). Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha. EMBO J, 27(1), 188-200. [1]. http://www.ncbi.nlm.nih.gov/pubmed/18046458?dopt=Citation

Vancouver

Ye H, Tan YLJ, Ponniah S, Takeda Y, Wang S-Q, Schachner M et al. Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha. EMBO J. 2008;27(1):188-200. 1.

Bibtex

@article{cb53142ff27341659b7c816d0f934781,
title = "Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha.",
abstract = "Apical dendrites of pyramidal neurons in the neocortex have a stereotypic orientation that is important for neuronal function. Neural recognition molecule Close Homolog of L1 (CHL1) has been shown to regulate oriented growth of apical dendrites in the mouse caudal cortex. Here we show that CHL1 directly associates with NB-3, a member of the F3/contactin family of neural recognition molecules, and enhances its cell surface expression. Similar to CHL1, NB-3 exhibits high-caudal to low-rostral expression in the deep layer neurons of the neocortex. NB-3-deficient mice show abnormal apical dendrite projections of deep layer pyramidal neurons in the visual cortex. Both CHL1 and NB-3 interact with protein tyrosine phosphatase alpha (PTPalpha) and regulate its activity. Moreover, deep layer pyramidal neurons of PTPalpha-deficient mice develop misoriented, even inverted, apical dendrites. We propose a signaling complex in which PTPalpha mediates CHL1 and NB-3-regulated apical dendrite projection in the developing caudal cortex.",
author = "Haihong Ye and Tan, {Yen Ling Jessie} and Sathivel Ponniah and Yasuo Takeda and Shi-Qiang Wang and Melitta Schachner and Kazutada Watanabe and Pallen, {Catherine J} and Zhi-Cheng Xiao",
year = "2008",
language = "Deutsch",
volume = "27",
pages = "188--200",
journal = "EMBO J",
issn = "0261-4189",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha.

AU - Ye, Haihong

AU - Tan, Yen Ling Jessie

AU - Ponniah, Sathivel

AU - Takeda, Yasuo

AU - Wang, Shi-Qiang

AU - Schachner, Melitta

AU - Watanabe, Kazutada

AU - Pallen, Catherine J

AU - Xiao, Zhi-Cheng

PY - 2008

Y1 - 2008

N2 - Apical dendrites of pyramidal neurons in the neocortex have a stereotypic orientation that is important for neuronal function. Neural recognition molecule Close Homolog of L1 (CHL1) has been shown to regulate oriented growth of apical dendrites in the mouse caudal cortex. Here we show that CHL1 directly associates with NB-3, a member of the F3/contactin family of neural recognition molecules, and enhances its cell surface expression. Similar to CHL1, NB-3 exhibits high-caudal to low-rostral expression in the deep layer neurons of the neocortex. NB-3-deficient mice show abnormal apical dendrite projections of deep layer pyramidal neurons in the visual cortex. Both CHL1 and NB-3 interact with protein tyrosine phosphatase alpha (PTPalpha) and regulate its activity. Moreover, deep layer pyramidal neurons of PTPalpha-deficient mice develop misoriented, even inverted, apical dendrites. We propose a signaling complex in which PTPalpha mediates CHL1 and NB-3-regulated apical dendrite projection in the developing caudal cortex.

AB - Apical dendrites of pyramidal neurons in the neocortex have a stereotypic orientation that is important for neuronal function. Neural recognition molecule Close Homolog of L1 (CHL1) has been shown to regulate oriented growth of apical dendrites in the mouse caudal cortex. Here we show that CHL1 directly associates with NB-3, a member of the F3/contactin family of neural recognition molecules, and enhances its cell surface expression. Similar to CHL1, NB-3 exhibits high-caudal to low-rostral expression in the deep layer neurons of the neocortex. NB-3-deficient mice show abnormal apical dendrite projections of deep layer pyramidal neurons in the visual cortex. Both CHL1 and NB-3 interact with protein tyrosine phosphatase alpha (PTPalpha) and regulate its activity. Moreover, deep layer pyramidal neurons of PTPalpha-deficient mice develop misoriented, even inverted, apical dendrites. We propose a signaling complex in which PTPalpha mediates CHL1 and NB-3-regulated apical dendrite projection in the developing caudal cortex.

M3 - SCORING: Zeitschriftenaufsatz

VL - 27

SP - 188

EP - 200

JO - EMBO J

JF - EMBO J

SN - 0261-4189

IS - 1

M1 - 1

ER -