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Neural mechanisms of placebo anxiolysis

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Neural mechanisms of placebo anxiolysis. / Meyer, Benjamin; Yuen, Kenneth S L; Ertl, Matthias; Polomac, Nenad; Mulert, Christoph; Büchel, Christian; Kalisch, Raffael.

in: J NEUROSCI, Jahrgang 35, Nr. 19, 13.05.2015, S. 7365-73.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Meyer, B, Yuen, KSL, Ertl, M, Polomac, N, Mulert, C, Büchel, C & Kalisch, R 2015, 'Neural mechanisms of placebo anxiolysis', J NEUROSCI, Jg. 35, Nr. 19, S. 7365-73. https://doi.org/10.1523/JNEUROSCI.4793-14.2015

APA

Meyer, B., Yuen, K. S. L., Ertl, M., Polomac, N., Mulert, C., Büchel, C., & Kalisch, R. (2015). Neural mechanisms of placebo anxiolysis. J NEUROSCI, 35(19), 7365-73. https://doi.org/10.1523/JNEUROSCI.4793-14.2015

Vancouver

Meyer B, Yuen KSL, Ertl M, Polomac N, Mulert C, Büchel C et al. Neural mechanisms of placebo anxiolysis. J NEUROSCI. 2015 Mai 13;35(19):7365-73. https://doi.org/10.1523/JNEUROSCI.4793-14.2015

Bibtex

@article{c6e0833d29f94f34ab431012ffb6fb91,
title = "Neural mechanisms of placebo anxiolysis",
abstract = "The beneficial effects of placebo treatments on fear and anxiety (placebo anxiolysis) are well known from clinical practice, and there is strong evidence indicating a contribution of treatment expectations to the efficacy of anxiolytic drugs. Although clinically highly relevant, the neural mechanisms underlying placebo anxiolysis are poorly understood. In two studies in humans, we tested whether the administration of an inactive treatment along with verbal suggestions of anxiolysis can attenuate experimentally induced states of phasic fear and/or sustained anxiety. Phasic fear is the response to a well defined threat and includes attentional focusing on the source of threat and concomitant phasic increases of autonomic arousal, whereas in sustained states of anxiety potential and unclear danger requires vigilant scanning of the environment and elevated tonic arousal levels. Our placebo manipulation consistently reduced vigilance measured in terms of undifferentiated reactivity to salient cues (indexed by subjective ratings, skin conductance responses and EEG event-related potentials) and tonic arousal [indexed by cue-unrelated skin conductance levels and enhanced EEG alpha (8-12 Hz) activity], indicating a downregulation of sustained anxiety rather than phasic fear. We also observed a placebo-dependent sustained increase of frontal midline EEG theta (4-7 Hz) power and frontoposterior theta coupling, suggesting the recruitment of frontally based cognitive control functions. Our results thus support the crucial role of treatment expectations in placebo anxiolysis and provide insight into the underlying neural mechanisms.",
keywords = "Adult, Anxiety, Brain, Brain Mapping, Cues, Electric Stimulation, Electroencephalography, Fear, Female, Galvanic Skin Response, Healthy Volunteers, Humans, Male, Middle Aged, Pain, Pain Measurement, Placebo Effect, Placebos, Time Factors, Young Adult",
author = "Benjamin Meyer and Yuen, {Kenneth S L} and Matthias Ertl and Nenad Polomac and Christoph Mulert and Christian B{\"u}chel and Raffael Kalisch",
note = "Copyright {\textcopyright} 2015 the authors 0270-6474/15/357365-09$15.00/0.",
year = "2015",
month = may,
day = "13",
doi = "10.1523/JNEUROSCI.4793-14.2015",
language = "English",
volume = "35",
pages = "7365--73",
journal = "J NEUROSCI",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "19",

}

RIS

TY - JOUR

T1 - Neural mechanisms of placebo anxiolysis

AU - Meyer, Benjamin

AU - Yuen, Kenneth S L

AU - Ertl, Matthias

AU - Polomac, Nenad

AU - Mulert, Christoph

AU - Büchel, Christian

AU - Kalisch, Raffael

N1 - Copyright © 2015 the authors 0270-6474/15/357365-09$15.00/0.

PY - 2015/5/13

Y1 - 2015/5/13

N2 - The beneficial effects of placebo treatments on fear and anxiety (placebo anxiolysis) are well known from clinical practice, and there is strong evidence indicating a contribution of treatment expectations to the efficacy of anxiolytic drugs. Although clinically highly relevant, the neural mechanisms underlying placebo anxiolysis are poorly understood. In two studies in humans, we tested whether the administration of an inactive treatment along with verbal suggestions of anxiolysis can attenuate experimentally induced states of phasic fear and/or sustained anxiety. Phasic fear is the response to a well defined threat and includes attentional focusing on the source of threat and concomitant phasic increases of autonomic arousal, whereas in sustained states of anxiety potential and unclear danger requires vigilant scanning of the environment and elevated tonic arousal levels. Our placebo manipulation consistently reduced vigilance measured in terms of undifferentiated reactivity to salient cues (indexed by subjective ratings, skin conductance responses and EEG event-related potentials) and tonic arousal [indexed by cue-unrelated skin conductance levels and enhanced EEG alpha (8-12 Hz) activity], indicating a downregulation of sustained anxiety rather than phasic fear. We also observed a placebo-dependent sustained increase of frontal midline EEG theta (4-7 Hz) power and frontoposterior theta coupling, suggesting the recruitment of frontally based cognitive control functions. Our results thus support the crucial role of treatment expectations in placebo anxiolysis and provide insight into the underlying neural mechanisms.

AB - The beneficial effects of placebo treatments on fear and anxiety (placebo anxiolysis) are well known from clinical practice, and there is strong evidence indicating a contribution of treatment expectations to the efficacy of anxiolytic drugs. Although clinically highly relevant, the neural mechanisms underlying placebo anxiolysis are poorly understood. In two studies in humans, we tested whether the administration of an inactive treatment along with verbal suggestions of anxiolysis can attenuate experimentally induced states of phasic fear and/or sustained anxiety. Phasic fear is the response to a well defined threat and includes attentional focusing on the source of threat and concomitant phasic increases of autonomic arousal, whereas in sustained states of anxiety potential and unclear danger requires vigilant scanning of the environment and elevated tonic arousal levels. Our placebo manipulation consistently reduced vigilance measured in terms of undifferentiated reactivity to salient cues (indexed by subjective ratings, skin conductance responses and EEG event-related potentials) and tonic arousal [indexed by cue-unrelated skin conductance levels and enhanced EEG alpha (8-12 Hz) activity], indicating a downregulation of sustained anxiety rather than phasic fear. We also observed a placebo-dependent sustained increase of frontal midline EEG theta (4-7 Hz) power and frontoposterior theta coupling, suggesting the recruitment of frontally based cognitive control functions. Our results thus support the crucial role of treatment expectations in placebo anxiolysis and provide insight into the underlying neural mechanisms.

KW - Adult

KW - Anxiety

KW - Brain

KW - Brain Mapping

KW - Cues

KW - Electric Stimulation

KW - Electroencephalography

KW - Fear

KW - Female

KW - Galvanic Skin Response

KW - Healthy Volunteers

KW - Humans

KW - Male

KW - Middle Aged

KW - Pain

KW - Pain Measurement

KW - Placebo Effect

KW - Placebos

KW - Time Factors

KW - Young Adult

U2 - 10.1523/JNEUROSCI.4793-14.2015

DO - 10.1523/JNEUROSCI.4793-14.2015

M3 - SCORING: Journal article

C2 - 25972166

VL - 35

SP - 7365

EP - 7373

JO - J NEUROSCI

JF - J NEUROSCI

SN - 0270-6474

IS - 19

ER -