Neural basis of reward anticipation and its genetic determinants
Standard
Neural basis of reward anticipation and its genetic determinants. / Jia, Tianye; Macare, Christine; Desrivières, Sylvane; Gonzalez, Dante A; Tao, Chenyang; Ji, Xiaoxi; Ruggeri, Barbara; Nees, Frauke; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Conrod, Patricia J; Dove, Rachel; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny A; Heinz, Andreas; Ittermann, Bernd; Lathrop, Mark; Lemaitre, Hervé; Martinot, Jean-Luc; Paus, Tomáš; Pausova, Zdenka; Poline, Jean-Baptiste; Rietschel, Marcella; Robbins, Trevor; Smolka, Michael N; Müller, Christian P; Feng, Jianfeng; Rothenfluh, Adrian; Flor, Herta; Schumann, Gunter; IMAGEN Consortium.
in: P NATL ACAD SCI USA, Jahrgang 113, Nr. 14, 05.04.2016, S. 3879-84.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Neural basis of reward anticipation and its genetic determinants
AU - Jia, Tianye
AU - Macare, Christine
AU - Desrivières, Sylvane
AU - Gonzalez, Dante A
AU - Tao, Chenyang
AU - Ji, Xiaoxi
AU - Ruggeri, Barbara
AU - Nees, Frauke
AU - Banaschewski, Tobias
AU - Barker, Gareth J
AU - Bokde, Arun L W
AU - Bromberg, Uli
AU - Büchel, Christian
AU - Conrod, Patricia J
AU - Dove, Rachel
AU - Frouin, Vincent
AU - Gallinat, Jürgen
AU - Garavan, Hugh
AU - Gowland, Penny A
AU - Heinz, Andreas
AU - Ittermann, Bernd
AU - Lathrop, Mark
AU - Lemaitre, Hervé
AU - Martinot, Jean-Luc
AU - Paus, Tomáš
AU - Pausova, Zdenka
AU - Poline, Jean-Baptiste
AU - Rietschel, Marcella
AU - Robbins, Trevor
AU - Smolka, Michael N
AU - Müller, Christian P
AU - Feng, Jianfeng
AU - Rothenfluh, Adrian
AU - Flor, Herta
AU - Schumann, Gunter
AU - IMAGEN Consortium
PY - 2016/4/5
Y1 - 2016/4/5
N2 - Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature.
AB - Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature.
U2 - 10.1073/pnas.1503252113
DO - 10.1073/pnas.1503252113
M3 - SCORING: Journal article
C2 - 27001827
VL - 113
SP - 3879
EP - 3884
JO - P NATL ACAD SCI USA
JF - P NATL ACAD SCI USA
SN - 0027-8424
IS - 14
ER -