Neural activation during processing of aversive faces predicts treatment outcome in alcoholism
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Neural activation during processing of aversive faces predicts treatment outcome in alcoholism. / Charlet, Katrin; Schlagenhauf, Florian; Richter, Anne; Naundorf, Karina; Dornhof, Lina; Weinfurtner, Christopher E J; König, Friederike; Walaszek, Bernadeta; Schubert, Florian; Müller, Christian A; Gutwinski, Stefan; Seissinger, Annette; Schmitz, Lioba; Walter, Henrik; Beck, Anne; Gallinat, Jürgen; Kiefer, Falk; Heinz, Andreas.
in: ADDICT BIOL, Jahrgang 19, Nr. 3, 05.2014, S. 439-51.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Neural activation during processing of aversive faces predicts treatment outcome in alcoholism
AU - Charlet, Katrin
AU - Schlagenhauf, Florian
AU - Richter, Anne
AU - Naundorf, Karina
AU - Dornhof, Lina
AU - Weinfurtner, Christopher E J
AU - König, Friederike
AU - Walaszek, Bernadeta
AU - Schubert, Florian
AU - Müller, Christian A
AU - Gutwinski, Stefan
AU - Seissinger, Annette
AU - Schmitz, Lioba
AU - Walter, Henrik
AU - Beck, Anne
AU - Gallinat, Jürgen
AU - Kiefer, Falk
AU - Heinz, Andreas
N1 - © 2013 The Authors, Addiction Biology © 2013 Society for the Study of Addiction.
PY - 2014/5
Y1 - 2014/5
N2 - Neuropsychological studies reported decoding deficits of emotional facial expressions in alcohol-dependent patients, and imaging studies revealed reduced prefrontal and limbic activation during emotional face processing. However, it remains unclear whether this reduced neural activation is mediated by alcohol-associated volume reductions and whether it interacts with treatment outcome. We combined analyses of neural activation during an aversive face-cue-comparison task and local gray matter volumes (GM) using Biological Parametric Mapping in 33 detoxified alcohol-dependent patients and 33 matched healthy controls. Alcoholics displayed reduced activation toward aversive faces-neutral shapes in bilateral fusiform gyrus [FG; Brodmann areas (BA) 18/19], right middle frontal gyrus (BA46/47), right inferior parietal gyrus (BA7) and left cerebellum compared with controls, which were explained by GM differences (except for cerebellum). Enhanced functional activation in patients versus controls was found in left rostral anterior cingulate cortex (ACC) and medial frontal gyrus (BA10/11), even after GM reduction control. Increased ACC activation correlated significantly with less (previous) lifetime alcohol intake [Lifetime Drinking History (LDH)], longer abstinence and less subsequent binge drinking in patients. High LDH appear to impair treatment outcome via its neurotoxicity on ACC integrity. Thus, high activation of the rostral ACC elicited by affective faces appears to be a resilience factor predicting better treatment outcome. Although no group differences were found, increased FG activation correlated with patients' higher LDH. Because high LDH correlated with worse task performance for facial stimuli in patients, elevated activation in the fusiform 'face' area may reflect inefficient compensatory activation. Therapeutic interventions (e.g. emotion evaluation training) may enable patients to cope with social stress and to decrease relapses after detoxification.
AB - Neuropsychological studies reported decoding deficits of emotional facial expressions in alcohol-dependent patients, and imaging studies revealed reduced prefrontal and limbic activation during emotional face processing. However, it remains unclear whether this reduced neural activation is mediated by alcohol-associated volume reductions and whether it interacts with treatment outcome. We combined analyses of neural activation during an aversive face-cue-comparison task and local gray matter volumes (GM) using Biological Parametric Mapping in 33 detoxified alcohol-dependent patients and 33 matched healthy controls. Alcoholics displayed reduced activation toward aversive faces-neutral shapes in bilateral fusiform gyrus [FG; Brodmann areas (BA) 18/19], right middle frontal gyrus (BA46/47), right inferior parietal gyrus (BA7) and left cerebellum compared with controls, which were explained by GM differences (except for cerebellum). Enhanced functional activation in patients versus controls was found in left rostral anterior cingulate cortex (ACC) and medial frontal gyrus (BA10/11), even after GM reduction control. Increased ACC activation correlated significantly with less (previous) lifetime alcohol intake [Lifetime Drinking History (LDH)], longer abstinence and less subsequent binge drinking in patients. High LDH appear to impair treatment outcome via its neurotoxicity on ACC integrity. Thus, high activation of the rostral ACC elicited by affective faces appears to be a resilience factor predicting better treatment outcome. Although no group differences were found, increased FG activation correlated with patients' higher LDH. Because high LDH correlated with worse task performance for facial stimuli in patients, elevated activation in the fusiform 'face' area may reflect inefficient compensatory activation. Therapeutic interventions (e.g. emotion evaluation training) may enable patients to cope with social stress and to decrease relapses after detoxification.
KW - Adult
KW - Alcoholism
KW - Brain Mapping
KW - Case-Control Studies
KW - Cerebellum
KW - Cerebral Cortex
KW - Cues
KW - Emotions
KW - Facial Expression
KW - Female
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Mental Processes
KW - Middle Aged
KW - Parietal Lobe
KW - Prefrontal Cortex
KW - Recurrence
KW - Temporal Lobe
KW - Treatment Outcome
U2 - 10.1111/adb.12045
DO - 10.1111/adb.12045
M3 - SCORING: Journal article
C2 - 23469861
VL - 19
SP - 439
EP - 451
JO - ADDICT BIOL
JF - ADDICT BIOL
SN - 1355-6215
IS - 3
ER -
