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Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing

Standard

Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing. / Sieben, Kay; Bieler, Malte; Röder, Brigitte; Hanganu-Opatz, Ileana L.

in: PLOS BIOL, Jahrgang 13, Nr. 11, 11.2015, S. Art. e1002304.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sieben, K, Bieler, M, Röder, B & Hanganu-Opatz, IL 2015, 'Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing', PLOS BIOL, Jg. 13, Nr. 11, S. Art. e1002304. https://doi.org/10.1371/journal.pbio.1002304

APA

Sieben, K., Bieler, M., Röder, B., & Hanganu-Opatz, I. L. (2015). Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing. PLOS BIOL, 13(11), Art. e1002304. https://doi.org/10.1371/journal.pbio.1002304

Vancouver

Sieben K, Bieler M, Röder B, Hanganu-Opatz IL. Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing. PLOS BIOL. 2015 Nov;13(11):Art. e1002304. https://doi.org/10.1371/journal.pbio.1002304

Bibtex

@article{22fd6818e9b74dfaa2cac6b031779b8c,
title = "Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing",
abstract = "Optimal behavior relies on the combination of inputs from multiple senses through complex interactions within neocortical networks. The ontogeny of this multisensory interplay is still unknown. Here, we identify critical factors that control the development of visual-tactile processing by combining in vivo electrophysiology with anatomical/functional assessment of cortico-cortical communication and behavioral investigation of pigmented rats. We demonstrate that the transient reduction of unimodal (tactile) inputs during a short period of neonatal development prior to the first cross-modal experience affects feed-forward subcortico-cortical interactions by attenuating the cross-modal enhancement of evoked responses in the adult primary somatosensory cortex. Moreover, the neonatal manipulation alters cortico-cortical interactions by decreasing the cross-modal synchrony and directionality in line with the sparsification of direct projections between primary somatosensory and visual cortices. At the behavioral level, these functional and structural deficits resulted in lower cross-modal matching abilities. Thus, neonatal unimodal experience during defined developmental stages is necessary for setting up the neuronal networks of multisensory processing.",
author = "Kay Sieben and Malte Bieler and Brigitte R{\"o}der and Hanganu-Opatz, {Ileana L}",
year = "2015",
month = nov,
doi = "10.1371/journal.pbio.1002304",
language = "English",
volume = "13",
pages = "Art. e1002304",
journal = "PLOS BIOL",
issn = "1544-9173",
publisher = "Public Library of Science",
number = "11",

}

RIS

TY - JOUR

T1 - Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing

AU - Sieben, Kay

AU - Bieler, Malte

AU - Röder, Brigitte

AU - Hanganu-Opatz, Ileana L

PY - 2015/11

Y1 - 2015/11

N2 - Optimal behavior relies on the combination of inputs from multiple senses through complex interactions within neocortical networks. The ontogeny of this multisensory interplay is still unknown. Here, we identify critical factors that control the development of visual-tactile processing by combining in vivo electrophysiology with anatomical/functional assessment of cortico-cortical communication and behavioral investigation of pigmented rats. We demonstrate that the transient reduction of unimodal (tactile) inputs during a short period of neonatal development prior to the first cross-modal experience affects feed-forward subcortico-cortical interactions by attenuating the cross-modal enhancement of evoked responses in the adult primary somatosensory cortex. Moreover, the neonatal manipulation alters cortico-cortical interactions by decreasing the cross-modal synchrony and directionality in line with the sparsification of direct projections between primary somatosensory and visual cortices. At the behavioral level, these functional and structural deficits resulted in lower cross-modal matching abilities. Thus, neonatal unimodal experience during defined developmental stages is necessary for setting up the neuronal networks of multisensory processing.

AB - Optimal behavior relies on the combination of inputs from multiple senses through complex interactions within neocortical networks. The ontogeny of this multisensory interplay is still unknown. Here, we identify critical factors that control the development of visual-tactile processing by combining in vivo electrophysiology with anatomical/functional assessment of cortico-cortical communication and behavioral investigation of pigmented rats. We demonstrate that the transient reduction of unimodal (tactile) inputs during a short period of neonatal development prior to the first cross-modal experience affects feed-forward subcortico-cortical interactions by attenuating the cross-modal enhancement of evoked responses in the adult primary somatosensory cortex. Moreover, the neonatal manipulation alters cortico-cortical interactions by decreasing the cross-modal synchrony and directionality in line with the sparsification of direct projections between primary somatosensory and visual cortices. At the behavioral level, these functional and structural deficits resulted in lower cross-modal matching abilities. Thus, neonatal unimodal experience during defined developmental stages is necessary for setting up the neuronal networks of multisensory processing.

U2 - 10.1371/journal.pbio.1002304

DO - 10.1371/journal.pbio.1002304

M3 - SCORING: Journal article

C2 - 26600123

VL - 13

SP - Art. e1002304

JO - PLOS BIOL

JF - PLOS BIOL

SN - 1544-9173

IS - 11

ER -