Neonatal hippocampal lesion alters the functional maturation of the prefrontal cortex and the early cognitive development in pre-juvenile rats.
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Neonatal hippocampal lesion alters the functional maturation of the prefrontal cortex and the early cognitive development in pre-juvenile rats. / Krüger, Hanna-Sophie; Brockmann, Marco David; Salamon, Johannes Martin; Ittrich, Harald; Hanganu-Opatz, Ileana.
in: NEUROBIOL LEARN MEM, Jahrgang 97, Nr. 4, 4, 2012, S. 470-481.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Neonatal hippocampal lesion alters the functional maturation of the prefrontal cortex and the early cognitive development in pre-juvenile rats.
AU - Krüger, Hanna-Sophie
AU - Brockmann, Marco David
AU - Salamon, Johannes Martin
AU - Ittrich, Harald
AU - Hanganu-Opatz, Ileana
PY - 2012
Y1 - 2012
N2 - Mnemonic and executive performance is encoded into activity patterns of complex neuronal networks. Lesion studies revealed that adult recognition memory critically depends on the activation of the prefrontal cortex (PFC) and hippocampus (HP). However, its developmental profile remains poorly elucidated. We previously showed the rat PFC and HP are functionally coupled in theta- and gamma-band oscillations during neonatal [postnatal day (P) 5-8] and pre-juvenile (P10-15) stages of development. Here, we assess the behavioral readout of this early prefrontal-hippocampal activation by investigating the ontogeny and the mechanisms of novelty detection and recognition memory in relationship to the functional integrity of the PFC and HP. Excitotoxic lesion of the HP at birth led to abnormal oscillatory entrainment of the PFC throughout neonatal and pre-juvenile development. Although the onset of novelty detection correlated rather with the maturation of sensory perception and motor skills than with hippocampal integrity, the pre-juvenile performance in item, spatial and temporal order recognition memory significantly decreased after HP lesion at birth. This poorer performance does result neither from abnormal developmental milestones and locomotion nor from increased anxiety. Thus, novelty recognition in rat emerges during the second postnatal week and requires functional integrity of communication within neuronal networks including the PFC and HP.
AB - Mnemonic and executive performance is encoded into activity patterns of complex neuronal networks. Lesion studies revealed that adult recognition memory critically depends on the activation of the prefrontal cortex (PFC) and hippocampus (HP). However, its developmental profile remains poorly elucidated. We previously showed the rat PFC and HP are functionally coupled in theta- and gamma-band oscillations during neonatal [postnatal day (P) 5-8] and pre-juvenile (P10-15) stages of development. Here, we assess the behavioral readout of this early prefrontal-hippocampal activation by investigating the ontogeny and the mechanisms of novelty detection and recognition memory in relationship to the functional integrity of the PFC and HP. Excitotoxic lesion of the HP at birth led to abnormal oscillatory entrainment of the PFC throughout neonatal and pre-juvenile development. Although the onset of novelty detection correlated rather with the maturation of sensory perception and motor skills than with hippocampal integrity, the pre-juvenile performance in item, spatial and temporal order recognition memory significantly decreased after HP lesion at birth. This poorer performance does result neither from abnormal developmental milestones and locomotion nor from increased anxiety. Thus, novelty recognition in rat emerges during the second postnatal week and requires functional integrity of communication within neuronal networks including the PFC and HP.
KW - Animals
KW - Male
KW - Rats
KW - Animals, Newborn
KW - Brain Waves/drug effects/physiology
KW - Excitatory Amino Acid Agonists/pharmacology
KW - Exploratory Behavior/drug effects/physiology
KW - Hippocampus/drug effects/physiology
KW - N-Methylaspartate/pharmacology
KW - Neural Pathways/drug effects/physiology
KW - Prefrontal Cortex/drug effects/growth & development/physiology
KW - Recognition (Psychology)/drug effects/physiology
KW - Animals
KW - Male
KW - Rats
KW - Animals, Newborn
KW - Brain Waves/drug effects/physiology
KW - Excitatory Amino Acid Agonists/pharmacology
KW - Exploratory Behavior/drug effects/physiology
KW - Hippocampus/drug effects/physiology
KW - N-Methylaspartate/pharmacology
KW - Neural Pathways/drug effects/physiology
KW - Prefrontal Cortex/drug effects/growth & development/physiology
KW - Recognition (Psychology)/drug effects/physiology
M3 - SCORING: Journal article
VL - 97
SP - 470
EP - 481
JO - NEUROBIOL LEARN MEM
JF - NEUROBIOL LEARN MEM
SN - 1074-7427
IS - 4
M1 - 4
ER -
