Neonatal cholinergic lesion alters the acoustic structure of infant rat vocalization but not the early cognitive development.
Standard
Neonatal cholinergic lesion alters the acoustic structure of infant rat vocalization but not the early cognitive development. / Krüger, Hanna-Sophie; Hanganu-Opatz, Ileana L.
in: DEV PSYCHOBIOL, Jahrgang 55, Nr. 3, 3, 2013, S. 294-308.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Neonatal cholinergic lesion alters the acoustic structure of infant rat vocalization but not the early cognitive development.
AU - Krüger, Hanna-Sophie
AU - Hanganu-Opatz, Ileana L
N1 - Copyright © 2012 Wiley Periodicals, Inc.
PY - 2013
Y1 - 2013
N2 - Cholinergic innervation is critically required for cytoarchitectonic maturation of the cerebral cortex as well as functional assembling of neuronal networks and their behavioral readout. Selective lesion of cortically projecting cholinergic neurons initiated immediately after birth by the immunotoxin 192 IgG-saporin (SAP) led to abnormal wiring of prefrontal-hippocampal networks, yet the neurobehavioral and cognitive consequences of this impairment are still poorly understood. Here, we show that partial cholinergic depletion initiated at birth did not impact the general development of rat pups during the first 2 postnatal weeks, their homing behavior, and the maturation of recognition memory. However, the acoustic structure of infant ultrasonic vocalization was significantly affected by SAP, indicating that early neurobehavioral development relies on intact cholinergic drive. This altered vocalization did not elicit differential maternal care, suggesting that the previously reported SAP-induced behavioral deficits at adulthood are the direct result of cholinergic depletion rather than of abnormal mother-pup interactions.
AB - Cholinergic innervation is critically required for cytoarchitectonic maturation of the cerebral cortex as well as functional assembling of neuronal networks and their behavioral readout. Selective lesion of cortically projecting cholinergic neurons initiated immediately after birth by the immunotoxin 192 IgG-saporin (SAP) led to abnormal wiring of prefrontal-hippocampal networks, yet the neurobehavioral and cognitive consequences of this impairment are still poorly understood. Here, we show that partial cholinergic depletion initiated at birth did not impact the general development of rat pups during the first 2 postnatal weeks, their homing behavior, and the maturation of recognition memory. However, the acoustic structure of infant ultrasonic vocalization was significantly affected by SAP, indicating that early neurobehavioral development relies on intact cholinergic drive. This altered vocalization did not elicit differential maternal care, suggesting that the previously reported SAP-induced behavioral deficits at adulthood are the direct result of cholinergic depletion rather than of abnormal mother-pup interactions.
KW - Acetylcholine
KW - Analysis of Variance
KW - Animals
KW - Animals, Newborn
KW - Antibodies, Monoclonal
KW - Behavior, Animal
KW - Cholinergic Agents
KW - Cholinergic Neurons
KW - Cognition
KW - Immunohistochemistry
KW - Male
KW - Rats
KW - Recognition (Psychology)
KW - Ribosome Inactivating Proteins, Type 1
KW - Vocalization, Animal
U2 - 10.1002/dev.21029
DO - 10.1002/dev.21029
M3 - SCORING: Journal article
C2 - 22488119
VL - 55
SP - 294
EP - 308
JO - DEV PSYCHOBIOL
JF - DEV PSYCHOBIOL
SN - 0012-1630
IS - 3
M1 - 3
ER -
