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Neo-adjuvant chemotherapy for operable breast cancer induces apoptosis

Standard

Neo-adjuvant chemotherapy for operable breast cancer induces apoptosis. / Shao, Z M; Wu, J; Han, Q X; Shen, Z Z; Fontana, J A; Barsky, S H.

in: BREAST CANCER RES TR, Jahrgang 53, Nr. 3, 02.1999, S. 263-9.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Shao, ZM, Wu, J, Han, QX, Shen, ZZ, Fontana, JA & Barsky, SH 1999, 'Neo-adjuvant chemotherapy for operable breast cancer induces apoptosis', BREAST CANCER RES TR, Jg. 53, Nr. 3, S. 263-9.

APA

Shao, Z. M., Wu, J., Han, Q. X., Shen, Z. Z., Fontana, J. A., & Barsky, S. H. (1999). Neo-adjuvant chemotherapy for operable breast cancer induces apoptosis. BREAST CANCER RES TR, 53(3), 263-9.

Vancouver

Shao ZM, Wu J, Han QX, Shen ZZ, Fontana JA, Barsky SH. Neo-adjuvant chemotherapy for operable breast cancer induces apoptosis. BREAST CANCER RES TR. 1999 Feb;53(3):263-9.

Bibtex

@article{8ec81ca6cde34778bbfd02757762f1d7,
title = "Neo-adjuvant chemotherapy for operable breast cancer induces apoptosis",
abstract = "The use of neo-adjuvant chemotherapy (often referred to as pre-operative or primary chemotherapy) represents a major change in the management of breast cancer as a systemic disease. Laboratory studies have shown that many anti-cancer agents with differing modes of action achieve cytotoxic effects by inducing apoptosis. In this study, we investigated the induction of apoptosis by neo-adjuvant chemotherapy in human breast cancer. The aim was to determine whether a correlation existed between post chemotherapy apoptotic index (AI) and clinical response and patients' survival. Our results indicate that apoptosis is induced by neo-adjuvant chemotherapy and that the response is variable. Our data show that post chemotherapy AI correlated with clinical response and increased patient survival, including both relapse (disease) free survival and overall survival. Post-neo-adjuvant chemotherapy AI levels in primary breast cancer may possibly predict an individual patient's overall response.",
keywords = "Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Breast Neoplasms, Chemotherapy, Adjuvant, Cyclophosphamide, Disease-Free Survival, Female, Fluorouracil, Follow-Up Studies, Humans, Methotrexate, Middle Aged, Multivariate Analysis, Neoadjuvant Therapy, Predictive Value of Tests, Prognosis, Receptors, Estrogen, Survival Rate, Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't",
author = "Shao, {Z M} and J Wu and Han, {Q X} and Shen, {Z Z} and Fontana, {J A} and Barsky, {S H}",
year = "1999",
month = feb,
language = "English",
volume = "53",
pages = "263--9",
journal = "BREAST CANCER RES TR",
issn = "0167-6806",
publisher = "Springer New York",
number = "3",

}

RIS

TY - JOUR

T1 - Neo-adjuvant chemotherapy for operable breast cancer induces apoptosis

AU - Shao, Z M

AU - Wu, J

AU - Han, Q X

AU - Shen, Z Z

AU - Fontana, J A

AU - Barsky, S H

PY - 1999/2

Y1 - 1999/2

N2 - The use of neo-adjuvant chemotherapy (often referred to as pre-operative or primary chemotherapy) represents a major change in the management of breast cancer as a systemic disease. Laboratory studies have shown that many anti-cancer agents with differing modes of action achieve cytotoxic effects by inducing apoptosis. In this study, we investigated the induction of apoptosis by neo-adjuvant chemotherapy in human breast cancer. The aim was to determine whether a correlation existed between post chemotherapy apoptotic index (AI) and clinical response and patients' survival. Our results indicate that apoptosis is induced by neo-adjuvant chemotherapy and that the response is variable. Our data show that post chemotherapy AI correlated with clinical response and increased patient survival, including both relapse (disease) free survival and overall survival. Post-neo-adjuvant chemotherapy AI levels in primary breast cancer may possibly predict an individual patient's overall response.

AB - The use of neo-adjuvant chemotherapy (often referred to as pre-operative or primary chemotherapy) represents a major change in the management of breast cancer as a systemic disease. Laboratory studies have shown that many anti-cancer agents with differing modes of action achieve cytotoxic effects by inducing apoptosis. In this study, we investigated the induction of apoptosis by neo-adjuvant chemotherapy in human breast cancer. The aim was to determine whether a correlation existed between post chemotherapy apoptotic index (AI) and clinical response and patients' survival. Our results indicate that apoptosis is induced by neo-adjuvant chemotherapy and that the response is variable. Our data show that post chemotherapy AI correlated with clinical response and increased patient survival, including both relapse (disease) free survival and overall survival. Post-neo-adjuvant chemotherapy AI levels in primary breast cancer may possibly predict an individual patient's overall response.

KW - Adult

KW - Aged

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Apoptosis

KW - Breast Neoplasms

KW - Chemotherapy, Adjuvant

KW - Cyclophosphamide

KW - Disease-Free Survival

KW - Female

KW - Fluorouracil

KW - Follow-Up Studies

KW - Humans

KW - Methotrexate

KW - Middle Aged

KW - Multivariate Analysis

KW - Neoadjuvant Therapy

KW - Predictive Value of Tests

KW - Prognosis

KW - Receptors, Estrogen

KW - Survival Rate

KW - Clinical Trial

KW - Journal Article

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

M3 - SCORING: Journal article

C2 - 10369072

VL - 53

SP - 263

EP - 269

JO - BREAST CANCER RES TR

JF - BREAST CANCER RES TR

SN - 0167-6806

IS - 3

ER -