Negative dip in BOLD fMRI is caused by blood flow--oxygen consumption uncoupling in humans.
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Negative dip in BOLD fMRI is caused by blood flow--oxygen consumption uncoupling in humans. / Röther, Joachim; Knab, Rene; Hamzei, Farsin; Fiehler, Jens; Reichenbach, Jürgen R; Büchel, Christian; Weiller, Cornelius.
in: NEUROIMAGE, Jahrgang 15, Nr. 1, 1, 2002, S. 98-102.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Negative dip in BOLD fMRI is caused by blood flow--oxygen consumption uncoupling in humans.
AU - Röther, Joachim
AU - Knab, Rene
AU - Hamzei, Farsin
AU - Fiehler, Jens
AU - Reichenbach, Jürgen R
AU - Büchel, Christian
AU - Weiller, Cornelius
PY - 2002
Y1 - 2002
N2 - The sensitivity of MRI for local changes in the deoxyhemoglobin concentration is the basis of the blood oxygen level dependent (BOLD) effect. Time-resolved fMRI studies during visual activation show an early signal intensity (SI) decrease indicating a short lasting uncoupling of oxygen consumption and cerebral blood flow (CBF) before a SI increase due to the overcompensating hemodynamic response occurs. Normal neuronal activity may be preserved despite absent vascular responsiveness. Here we show that a negative BOLD effect occurs during motor activation in an asymptomatic patient with severely disturbed cerebral autoregulation due to extracranial artery disease. This is thought to be due to oxygen consumption in the absence of a hemodynamic response. This rare case of a persisting uncoupling of oxygen metabolism and CBF serves as a model that supports changes of the cerebral blood oxygen saturation as the major contributor of the BOLD effect.
AB - The sensitivity of MRI for local changes in the deoxyhemoglobin concentration is the basis of the blood oxygen level dependent (BOLD) effect. Time-resolved fMRI studies during visual activation show an early signal intensity (SI) decrease indicating a short lasting uncoupling of oxygen consumption and cerebral blood flow (CBF) before a SI increase due to the overcompensating hemodynamic response occurs. Normal neuronal activity may be preserved despite absent vascular responsiveness. Here we show that a negative BOLD effect occurs during motor activation in an asymptomatic patient with severely disturbed cerebral autoregulation due to extracranial artery disease. This is thought to be due to oxygen consumption in the absence of a hemodynamic response. This rare case of a persisting uncoupling of oxygen metabolism and CBF serves as a model that supports changes of the cerebral blood oxygen saturation as the major contributor of the BOLD effect.
M3 - SCORING: Zeitschriftenaufsatz
VL - 15
SP - 98
EP - 102
JO - NEUROIMAGE
JF - NEUROIMAGE
SN - 1053-8119
IS - 1
M1 - 1
ER -
