Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ-Global Registry for Emerging Fungal Infections

ECMM/ISHAM working group; Melina Heinemann

doi:10.1016/j.jinf.2020.08.015

Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ-Global Registry for Emerging Fungal Infections

Standard

Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ-Global Registry for Emerging Fungal Infections. / ECMM/ISHAM working group ; Heinemann, Melina.

in: J INFECTION, Jahrgang 81, Nr. 5, 5, 11.2020, S. 802-815.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

ECMM/ISHAM working group & Heinemann, M 2020, 'Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ-Global Registry for Emerging Fungal Infections', J INFECTION, Jg. 81, Nr. 5, 5, S. 802-815. https://doi.org/10.1016/j.jinf.2020.08.015

APA

ECMM/ISHAM working group, & Heinemann, M. (2020). Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ-Global Registry for Emerging Fungal Infections. J INFECTION, 81(5), 802-815. [5]. https://doi.org/10.1016/j.jinf.2020.08.015

Vancouver

ECMM/ISHAM working group, Heinemann M. Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ-Global Registry for Emerging Fungal Infections. J INFECTION. 2020 Nov;81(5):802-815. 5. https://doi.org/10.1016/j.jinf.2020.08.015

Bibtex

@article{1bf017fbdecd4bb4bd2239a07fb35914,

title = "Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ-Global Registry for Emerging Fungal Infections",

abstract = "OBJECTIVES: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI.METHODS: Extremely rare IFI collected in the FungiScopeⓇ registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales.RESULTS: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScopeⓇ. Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales.CONCLUSIONS: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens.",

author = "Jon Salmanton-Garc{\'i}a and Philipp Koehler and Anupma Kindo and Iker Falces-Romero and Julio Garc{\'i}a-Rodr{\'i}guez and Zden{\v e}k R{\'a}{\v c}il and Chen, {Sharon C-A} and Nikolai Klimko and Guillaume Desoubeaux and Thompson, {George R} and Miguel-{\'A}ngel Ben{\'i}tez-Pe{\~n}uela and Jos{\'e}-Yesid Rodr{\'i}guez and Sheppard, {Donald C} and Martin Hoenigl and {Le Govic}, Yohann and Hamid Badali and Baddley, {John W} and Jagdish Chander and Ingram, {Paul R} and Pakstis, {Diana L} and Mellinghoff, {Sibylle C} and Serkan Atıcı and Simone Cesaro and Arunaloke Chakrabarti and Damien Dupont and Gonz{\'a}lez, {Gloria M} and L{\'o}r{\'a}nt Hatvani and Raoul Herbrecht and Galina Klyasova and Cornelia Lass-Fl{\"o}rl and Mihai Mareș and Kathleen Mullane and Vinh, {Donald C} and Hilmar Wisplinghoff and Michaela Lackner and Cornely, {Oliver A} and Danila Seidel and {ECMM/ISHAM working group} and Melina Heinemann",

year = "2020",

month = nov,

doi = "10.1016/j.jinf.2020.08.015",

language = "English",

volume = "81",

pages = "802--815",

journal = "J INFECTION",

issn = "0163-4453",

publisher = "W.B. Saunders Ltd",

number = "5",

}

RIS

TY - JOUR

T1 - Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ-Global Registry for Emerging Fungal Infections

AU - Salmanton-García, Jon

AU - Koehler, Philipp

AU - Kindo, Anupma

AU - Falces-Romero, Iker

AU - García-Rodríguez, Julio

AU - Ráčil, Zdeněk

AU - Chen, Sharon C-A

AU - Klimko, Nikolai

AU - Desoubeaux, Guillaume

AU - Thompson, George R

AU - Benítez-Peñuela, Miguel-Ángel

AU - Rodríguez, José-Yesid

AU - Sheppard, Donald C

AU - Hoenigl, Martin

AU - Le Govic, Yohann

AU - Badali, Hamid

AU - Baddley, John W

AU - Chander, Jagdish

AU - Ingram, Paul R

AU - Pakstis, Diana L

AU - Mellinghoff, Sibylle C

AU - Atıcı, Serkan

AU - Cesaro, Simone

AU - Chakrabarti, Arunaloke

AU - Dupont, Damien

AU - González, Gloria M

AU - Hatvani, Lóránt

AU - Herbrecht, Raoul

AU - Klyasova, Galina

AU - Lass-Flörl, Cornelia

AU - Mareș, Mihai

AU - Mullane, Kathleen

AU - Vinh, Donald C

AU - Wisplinghoff, Hilmar

AU - Lackner, Michaela

AU - Cornely, Oliver A

AU - Seidel, Danila

AU - ECMM/ISHAM working group

AU - Heinemann, Melina

PY - 2020/11

Y1 - 2020/11

N2 - OBJECTIVES: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI.METHODS: Extremely rare IFI collected in the FungiScopeⓇ registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales.RESULTS: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScopeⓇ. Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales.CONCLUSIONS: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens.

AB - OBJECTIVES: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI.METHODS: Extremely rare IFI collected in the FungiScopeⓇ registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales.RESULTS: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScopeⓇ. Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales.CONCLUSIONS: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens.

U2 - 10.1016/j.jinf.2020.08.015

DO - 10.1016/j.jinf.2020.08.015

M3 - SCORING: Journal article

C2 - 32798532

VL - 81

SP - 802

EP - 815

JO - J INFECTION

JF - J INFECTION

SN - 0163-4453

IS - 5

M1 - 5

ER -