Near-Infrared Autofluorescence in Choroideremia: Anatomic and Functional Correlations
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Near-Infrared Autofluorescence in Choroideremia: Anatomic and Functional Correlations. / Birtel, Johannes; Salvetti, Anna Paola; Jolly, Jasleen K; Xue, Kanmin; Gliem, Martin; Müller, Philipp L; Holz, Frank G; MacLaren, Robert E; Charbel Issa, Peter.
in: AM J OPHTHALMOL, Jahrgang 199, 03.2019, S. 19-27.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Near-Infrared Autofluorescence in Choroideremia: Anatomic and Functional Correlations
AU - Birtel, Johannes
AU - Salvetti, Anna Paola
AU - Jolly, Jasleen K
AU - Xue, Kanmin
AU - Gliem, Martin
AU - Müller, Philipp L
AU - Holz, Frank G
AU - MacLaren, Robert E
AU - Charbel Issa, Peter
N1 - Copyright © 2018 Elsevier Inc. All rights reserved.
PY - 2019/3
Y1 - 2019/3
N2 - PURPOSE: To investigate near-infrared fundus autofluorescence (NIR-AF) characteristics in patients with choroideremia and to correlate these with anatomic and functional parameters.DESIGN: Retrospective, observational case series.METHODS: In this multicenter study, 43 consecutive choroideremia patients (79 eyes) underwent multimodal retinal imaging, including near-infrared fundus autofluorescence (NIR-AF), blue autofluorescence (B-AF), optical coherence tomography (OCT), fundus photography, and functional testing including fundus-controlled microperimetry.RESULTS: All eyes could be categorized into 3 groups based on patterns of NIR-AF over the island of surviving retinal pigment epithelium: Group 1 (preserved NIR-AF centrally), Group 2 (only disrupted NIR-AF), or Group 3 (absence of NIR-AF). Group 1 eyes showed areas of NIR-AF that matched the areas of B-AF islands (R2 = 0.94, slope 0.84 ± 0.04) while Group 2 eyes showed significantly smaller areas of NIR-AF compared with B-AF (R2 = 0.08; slope 0.02 ± 0.01). The 3 groups differed significantly in terms of residual B-AF island size (P < .0001), length of foveal ellipsoid zone (P = .03), foveal thickness (P = .04), and foveal sensitivity (P = .01). Visual acuity (P = .07) and central retinal thickness (P = .06) did not differ statistically. The length of the ellipsoid zone line was similar to the horizontal diameter of NIR-AF in Group 1 (R2 = 0.97, slope 0.96 ± 0.04), while Group 2 eyes showed broader ellipsoid zone than NIR-AF (R2 = 0.60, slope 0.19 ± 0.03).CONCLUSIONS: Choroideremia patients can be stratified into 3 groups based on NIR-AF imaging, which showed morphologic and functional changes correlating with different stages of retinal pigment epithelium degeneration. NIR-AF could be a marker for disease staging in choroideremia, and could be used for patient selection or as an outcome parameter in interventional trials.
AB - PURPOSE: To investigate near-infrared fundus autofluorescence (NIR-AF) characteristics in patients with choroideremia and to correlate these with anatomic and functional parameters.DESIGN: Retrospective, observational case series.METHODS: In this multicenter study, 43 consecutive choroideremia patients (79 eyes) underwent multimodal retinal imaging, including near-infrared fundus autofluorescence (NIR-AF), blue autofluorescence (B-AF), optical coherence tomography (OCT), fundus photography, and functional testing including fundus-controlled microperimetry.RESULTS: All eyes could be categorized into 3 groups based on patterns of NIR-AF over the island of surviving retinal pigment epithelium: Group 1 (preserved NIR-AF centrally), Group 2 (only disrupted NIR-AF), or Group 3 (absence of NIR-AF). Group 1 eyes showed areas of NIR-AF that matched the areas of B-AF islands (R2 = 0.94, slope 0.84 ± 0.04) while Group 2 eyes showed significantly smaller areas of NIR-AF compared with B-AF (R2 = 0.08; slope 0.02 ± 0.01). The 3 groups differed significantly in terms of residual B-AF island size (P < .0001), length of foveal ellipsoid zone (P = .03), foveal thickness (P = .04), and foveal sensitivity (P = .01). Visual acuity (P = .07) and central retinal thickness (P = .06) did not differ statistically. The length of the ellipsoid zone line was similar to the horizontal diameter of NIR-AF in Group 1 (R2 = 0.97, slope 0.96 ± 0.04), while Group 2 eyes showed broader ellipsoid zone than NIR-AF (R2 = 0.60, slope 0.19 ± 0.03).CONCLUSIONS: Choroideremia patients can be stratified into 3 groups based on NIR-AF imaging, which showed morphologic and functional changes correlating with different stages of retinal pigment epithelium degeneration. NIR-AF could be a marker for disease staging in choroideremia, and could be used for patient selection or as an outcome parameter in interventional trials.
KW - Adult
KW - Aged
KW - Choroideremia/classification
KW - Female
KW - Humans
KW - Infrared Rays
KW - Male
KW - Middle Aged
KW - Multimodal Imaging
KW - Optical Imaging
KW - Photography
KW - Retrospective Studies
KW - Tomography, Optical Coherence
KW - Visual Acuity/physiology
KW - Visual Field Tests
KW - Visual Fields/physiology
U2 - 10.1016/j.ajo.2018.10.021
DO - 10.1016/j.ajo.2018.10.021
M3 - SCORING: Journal article
C2 - 30713139
VL - 199
SP - 19
EP - 27
JO - AM J OPHTHALMOL
JF - AM J OPHTHALMOL
SN - 0002-9394
ER -
