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NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes

Standard

NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes. / Cui, Xiao-Ying; Hu, Qi-Dong; Tekaya, Meriem; Shimoda, Yasushi; Ang, Beng-Ti; Nie, Du-Yu; Sun, Li; Hu, Wei-Ping; Karsak, Meliha; Duka, Tanya; Takeda, Yasuo; Ou, Lian-Yun; Dawe, Gavin S; Yu, Feng-Gang; Ahmed, Sohail; Jin, Lian-Hong; Schachner, Melitta; Watanabe, Kazutada; Arsenijevic, Yvan; Xiao, Zhi-Cheng.

in: J BIOL CHEM, Jahrgang 279, Nr. 24, 11.06.2004, S. 25858-65.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Cui, X-Y, Hu, Q-D, Tekaya, M, Shimoda, Y, Ang, B-T, Nie, D-Y, Sun, L, Hu, W-P, Karsak, M, Duka, T, Takeda, Y, Ou, L-Y, Dawe, GS, Yu, F-G, Ahmed, S, Jin, L-H, Schachner, M, Watanabe, K, Arsenijevic, Y & Xiao, Z-C 2004, 'NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes', J BIOL CHEM, Jg. 279, Nr. 24, S. 25858-65. https://doi.org/10.1074/jbc.M313505200

APA

Cui, X-Y., Hu, Q-D., Tekaya, M., Shimoda, Y., Ang, B-T., Nie, D-Y., Sun, L., Hu, W-P., Karsak, M., Duka, T., Takeda, Y., Ou, L-Y., Dawe, G. S., Yu, F-G., Ahmed, S., Jin, L-H., Schachner, M., Watanabe, K., Arsenijevic, Y., & Xiao, Z-C. (2004). NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes. J BIOL CHEM, 279(24), 25858-65. https://doi.org/10.1074/jbc.M313505200

Vancouver

Cui X-Y, Hu Q-D, Tekaya M, Shimoda Y, Ang B-T, Nie D-Y et al. NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes. J BIOL CHEM. 2004 Jun 11;279(24):25858-65. https://doi.org/10.1074/jbc.M313505200

Bibtex

@article{90953b29883748cb99d4a371dbd514e6,
title = "NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes",
abstract = "Neurons and glia in the vertebrate central nervous system arise in temporally distinct, albeit overlapping, phases. Neurons are generated first followed by astrocytes and oligodendrocytes from common progenitor cells. Increasing evidence indicates that axon-derived signals spatiotemporally modulate oligodendrocyte maturation and myelin formation. Our previous observations demonstrate that F3/contactin is a functional ligand of Notch during oligodendrocyte maturation, revealing the existence of another group of Notch ligands. Here, we establish that NB-3, a member of the F3/contactin family, acts as a novel Notch ligand to participate in oligodendrocyte generation. NB-3 triggers nuclear translocation of the Notch intracellular domain and promotes oligodendrogliogenesis from progenitor cells and differentiation of oligodendrocyte precursor cells via Deltex1. In primary oligodendrocytes, NB-3 increases myelin-associated glycoprotein transcripts. Thus, the NB-3/Notch signaling pathway may prove to be a molecular handle to treat demyelinating diseases.",
keywords = "Active Transport, Cell Nucleus, Animals, Carrier Proteins/physiology, Cell Adhesion Molecules, Neuronal/physiology, Cell Differentiation, Cells, Cultured, Contactins, Mice, Mice, Inbred BALB C, Neurons/cytology, Oligodendroglia/cytology, Rats, Rats, Wistar, Receptor, Notch1, Receptors, Cell Surface/physiology, Signal Transduction, Stem Cells/cytology, Transcription Factors",
author = "Xiao-Ying Cui and Qi-Dong Hu and Meriem Tekaya and Yasushi Shimoda and Beng-Ti Ang and Du-Yu Nie and Li Sun and Wei-Ping Hu and Meliha Karsak and Tanya Duka and Yasuo Takeda and Lian-Yun Ou and Dawe, {Gavin S} and Feng-Gang Yu and Sohail Ahmed and Lian-Hong Jin and Melitta Schachner and Kazutada Watanabe and Yvan Arsenijevic and Zhi-Cheng Xiao",
year = "2004",
month = jun,
day = "11",
doi = "10.1074/jbc.M313505200",
language = "English",
volume = "279",
pages = "25858--65",
journal = "J BIOL CHEM",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "24",

}

RIS

TY - JOUR

T1 - NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes

AU - Cui, Xiao-Ying

AU - Hu, Qi-Dong

AU - Tekaya, Meriem

AU - Shimoda, Yasushi

AU - Ang, Beng-Ti

AU - Nie, Du-Yu

AU - Sun, Li

AU - Hu, Wei-Ping

AU - Karsak, Meliha

AU - Duka, Tanya

AU - Takeda, Yasuo

AU - Ou, Lian-Yun

AU - Dawe, Gavin S

AU - Yu, Feng-Gang

AU - Ahmed, Sohail

AU - Jin, Lian-Hong

AU - Schachner, Melitta

AU - Watanabe, Kazutada

AU - Arsenijevic, Yvan

AU - Xiao, Zhi-Cheng

PY - 2004/6/11

Y1 - 2004/6/11

N2 - Neurons and glia in the vertebrate central nervous system arise in temporally distinct, albeit overlapping, phases. Neurons are generated first followed by astrocytes and oligodendrocytes from common progenitor cells. Increasing evidence indicates that axon-derived signals spatiotemporally modulate oligodendrocyte maturation and myelin formation. Our previous observations demonstrate that F3/contactin is a functional ligand of Notch during oligodendrocyte maturation, revealing the existence of another group of Notch ligands. Here, we establish that NB-3, a member of the F3/contactin family, acts as a novel Notch ligand to participate in oligodendrocyte generation. NB-3 triggers nuclear translocation of the Notch intracellular domain and promotes oligodendrogliogenesis from progenitor cells and differentiation of oligodendrocyte precursor cells via Deltex1. In primary oligodendrocytes, NB-3 increases myelin-associated glycoprotein transcripts. Thus, the NB-3/Notch signaling pathway may prove to be a molecular handle to treat demyelinating diseases.

AB - Neurons and glia in the vertebrate central nervous system arise in temporally distinct, albeit overlapping, phases. Neurons are generated first followed by astrocytes and oligodendrocytes from common progenitor cells. Increasing evidence indicates that axon-derived signals spatiotemporally modulate oligodendrocyte maturation and myelin formation. Our previous observations demonstrate that F3/contactin is a functional ligand of Notch during oligodendrocyte maturation, revealing the existence of another group of Notch ligands. Here, we establish that NB-3, a member of the F3/contactin family, acts as a novel Notch ligand to participate in oligodendrocyte generation. NB-3 triggers nuclear translocation of the Notch intracellular domain and promotes oligodendrogliogenesis from progenitor cells and differentiation of oligodendrocyte precursor cells via Deltex1. In primary oligodendrocytes, NB-3 increases myelin-associated glycoprotein transcripts. Thus, the NB-3/Notch signaling pathway may prove to be a molecular handle to treat demyelinating diseases.

KW - Active Transport, Cell Nucleus

KW - Animals

KW - Carrier Proteins/physiology

KW - Cell Adhesion Molecules, Neuronal/physiology

KW - Cell Differentiation

KW - Cells, Cultured

KW - Contactins

KW - Mice

KW - Mice, Inbred BALB C

KW - Neurons/cytology

KW - Oligodendroglia/cytology

KW - Rats

KW - Rats, Wistar

KW - Receptor, Notch1

KW - Receptors, Cell Surface/physiology

KW - Signal Transduction

KW - Stem Cells/cytology

KW - Transcription Factors

U2 - 10.1074/jbc.M313505200

DO - 10.1074/jbc.M313505200

M3 - SCORING: Journal article

C2 - 15082708

VL - 279

SP - 25858

EP - 25865

JO - J BIOL CHEM

JF - J BIOL CHEM

SN - 0021-9258

IS - 24

ER -