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Nationwide Routine-Data Analysis of Sex Differences in Outcome of Acute Myocardial Infarction

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Nationwide Routine-Data Analysis of Sex Differences in Outcome of Acute Myocardial Infarction. / Freisinger, Eva; Sehner, Susanne; Malyar, Nasser M; Suling, Anna; Reinecke, Holger; Wegscheider, Karl.

in: CLIN CARDIOL, Jahrgang 41, Nr. 8, 08.2018, S. 1013-1021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Freisinger, E, Sehner, S, Malyar, NM, Suling, A, Reinecke, H & Wegscheider, K 2018, 'Nationwide Routine-Data Analysis of Sex Differences in Outcome of Acute Myocardial Infarction', CLIN CARDIOL, Jg. 41, Nr. 8, S. 1013-1021. https://doi.org/10.1002/clc.22962

APA

Freisinger, E., Sehner, S., Malyar, N. M., Suling, A., Reinecke, H., & Wegscheider, K. (2018). Nationwide Routine-Data Analysis of Sex Differences in Outcome of Acute Myocardial Infarction. CLIN CARDIOL, 41(8), 1013-1021. https://doi.org/10.1002/clc.22962

Vancouver

Freisinger E, Sehner S, Malyar NM, Suling A, Reinecke H, Wegscheider K. Nationwide Routine-Data Analysis of Sex Differences in Outcome of Acute Myocardial Infarction. CLIN CARDIOL. 2018 Aug;41(8):1013-1021. https://doi.org/10.1002/clc.22962

Bibtex

@article{31d7c092003f4a3fa6da5b383f5998b6,
title = "Nationwide Routine-Data Analysis of Sex Differences in Outcome of Acute Myocardial Infarction",
abstract = "Women have been reported to suffer from impaired outcome after acute myocardial infarction (AMI). The aim of our study was to determine the impact of sex and age on utilization of inpatient healthcare and outcome in patients with AMI (STEMI and NSTEMI) in a real-life setting. We performed a routine-data-based analysis of 203 106 nationwide inpatients hospitalized with STEMI and NSTEMI, focusing on sex differences regarding risk constellation, treatments, and in-hospital outcome. A logistic regression model was designed to evaluate the use of coronary angiography and interventions and their sex-related impact on mortality (within 30 days). Compared with males, female STEMI patients (25 146, vs 52 965 males) were older and had a higher incidence of diabetes mellitus (27.4% vs 20.6%), heart failure (32.8% vs 26.2%), and chronic kidney disease (19.1% vs 13.5%, respectively; all P < 0.05), and had higher observed in-hospital mortality (STEMI, 16.9% vs 9.9%; NSTEMI, 11.7% vs 8.7%). Females were less likely to receive coronary angiography in STEMI in the age groups <60 and ≥ 80 years (odds ratio: 0.8, 95% confidence interval: 0.76-0.83, P < 0.05), despite similar mortality risk reduction. Estimated overall in-hospital mortality showed no differences with respect to sex in STEMI for age groups 40 to 79 years. However, females age ≥ 80 years had slightly higher in-hospital mortality after adjustment. The increased observed in-hospital mortality in females was attributed to the impact of more unfavorable risk and age distribution. Coronary angiography was associated with lower in-hospital mortality; particularly, older females were less frequently treated.",
keywords = "Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Coronary Angiography, Female, Germany, Hospital Mortality, Humans, Incidence, Male, Middle Aged, Myocardial Infarction, Population Surveillance, Prognosis, Risk Assessment, Risk Factors, Sex Distribution, Sex Factors, Journal Article, Multicenter Study",
author = "Eva Freisinger and Susanne Sehner and Malyar, {Nasser M} and Anna Suling and Holger Reinecke and Karl Wegscheider",
note = "{\textcopyright} 2018 Wiley Periodicals, Inc.",
year = "2018",
month = aug,
doi = "10.1002/clc.22962",
language = "English",
volume = "41",
pages = "1013--1021",
journal = "CLIN CARDIOL",
issn = "0160-9289",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Nationwide Routine-Data Analysis of Sex Differences in Outcome of Acute Myocardial Infarction

AU - Freisinger, Eva

AU - Sehner, Susanne

AU - Malyar, Nasser M

AU - Suling, Anna

AU - Reinecke, Holger

AU - Wegscheider, Karl

N1 - © 2018 Wiley Periodicals, Inc.

PY - 2018/8

Y1 - 2018/8

N2 - Women have been reported to suffer from impaired outcome after acute myocardial infarction (AMI). The aim of our study was to determine the impact of sex and age on utilization of inpatient healthcare and outcome in patients with AMI (STEMI and NSTEMI) in a real-life setting. We performed a routine-data-based analysis of 203 106 nationwide inpatients hospitalized with STEMI and NSTEMI, focusing on sex differences regarding risk constellation, treatments, and in-hospital outcome. A logistic regression model was designed to evaluate the use of coronary angiography and interventions and their sex-related impact on mortality (within 30 days). Compared with males, female STEMI patients (25 146, vs 52 965 males) were older and had a higher incidence of diabetes mellitus (27.4% vs 20.6%), heart failure (32.8% vs 26.2%), and chronic kidney disease (19.1% vs 13.5%, respectively; all P < 0.05), and had higher observed in-hospital mortality (STEMI, 16.9% vs 9.9%; NSTEMI, 11.7% vs 8.7%). Females were less likely to receive coronary angiography in STEMI in the age groups <60 and ≥ 80 years (odds ratio: 0.8, 95% confidence interval: 0.76-0.83, P < 0.05), despite similar mortality risk reduction. Estimated overall in-hospital mortality showed no differences with respect to sex in STEMI for age groups 40 to 79 years. However, females age ≥ 80 years had slightly higher in-hospital mortality after adjustment. The increased observed in-hospital mortality in females was attributed to the impact of more unfavorable risk and age distribution. Coronary angiography was associated with lower in-hospital mortality; particularly, older females were less frequently treated.

AB - Women have been reported to suffer from impaired outcome after acute myocardial infarction (AMI). The aim of our study was to determine the impact of sex and age on utilization of inpatient healthcare and outcome in patients with AMI (STEMI and NSTEMI) in a real-life setting. We performed a routine-data-based analysis of 203 106 nationwide inpatients hospitalized with STEMI and NSTEMI, focusing on sex differences regarding risk constellation, treatments, and in-hospital outcome. A logistic regression model was designed to evaluate the use of coronary angiography and interventions and their sex-related impact on mortality (within 30 days). Compared with males, female STEMI patients (25 146, vs 52 965 males) were older and had a higher incidence of diabetes mellitus (27.4% vs 20.6%), heart failure (32.8% vs 26.2%), and chronic kidney disease (19.1% vs 13.5%, respectively; all P < 0.05), and had higher observed in-hospital mortality (STEMI, 16.9% vs 9.9%; NSTEMI, 11.7% vs 8.7%). Females were less likely to receive coronary angiography in STEMI in the age groups <60 and ≥ 80 years (odds ratio: 0.8, 95% confidence interval: 0.76-0.83, P < 0.05), despite similar mortality risk reduction. Estimated overall in-hospital mortality showed no differences with respect to sex in STEMI for age groups 40 to 79 years. However, females age ≥ 80 years had slightly higher in-hospital mortality after adjustment. The increased observed in-hospital mortality in females was attributed to the impact of more unfavorable risk and age distribution. Coronary angiography was associated with lower in-hospital mortality; particularly, older females were less frequently treated.

KW - Adult

KW - Age Distribution

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Coronary Angiography

KW - Female

KW - Germany

KW - Hospital Mortality

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Population Surveillance

KW - Prognosis

KW - Risk Assessment

KW - Risk Factors

KW - Sex Distribution

KW - Sex Factors

KW - Journal Article

KW - Multicenter Study

U2 - 10.1002/clc.22962

DO - 10.1002/clc.22962

M3 - SCORING: Journal article

C2 - 29667216

VL - 41

SP - 1013

EP - 1021

JO - CLIN CARDIOL

JF - CLIN CARDIOL

SN - 0160-9289

IS - 8

ER -