Nasolabial cyst: case report with respect to immunohistochemical findings.
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Nasolabial cyst: case report with respect to immunohistochemical findings. / Friedrich, Reinhard; Scheuer, Hanna; Assaf, Alexandre; Zustin, Jozef.
in: IN VIVO, Jahrgang 26, Nr. 3, 3, 2012, S. 453-458.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Nasolabial cyst: case report with respect to immunohistochemical findings.
AU - Friedrich, Reinhard
AU - Scheuer, Hanna
AU - Assaf, Alexandre
AU - Zustin, Jozef
PY - 2012
Y1 - 2012
N2 - The nasolabial cyst is a rare, usually unilateral lesion arising in the soft tissues adjacent to the alveolar process of the anterior maxilla, above the apices of frontal teeth and below the alar base. The typical clinical features of nasolabial cysts are: swelling between the upper lip and nasal aperture caused by a smooth and fluctuant, well defined space-occupying lesion, elevation of the nasal ala and obliteration of the nasolabial fold. This report describes some clinical, radiological and morphological findings in a nasolabial cyst. The cyst was lined up with bilayered epithelium showing scattered goblet cells. The immunohistochemical analysis revealed that the basaloid epithelial cells exhibited nuclear positive reactions for p63. The proliferative activity of the epithelial cells was low (<5%). Reaction for podoplanin was only discretely positive in basal cells within the non-inflamed portions but was enhanced in areas with inflammatory changes of the cyst wall. Cytokeratin subtyping showed a distinct expression of intermediate filaments in the nasolabial cyst. Nasolabial cysts are developmental cysts that can be cured by adequate surgical techniques. The expression pattern of podoplanin in this entity points to an association of this protein expression with inflammatory reactions to the cyst.
AB - The nasolabial cyst is a rare, usually unilateral lesion arising in the soft tissues adjacent to the alveolar process of the anterior maxilla, above the apices of frontal teeth and below the alar base. The typical clinical features of nasolabial cysts are: swelling between the upper lip and nasal aperture caused by a smooth and fluctuant, well defined space-occupying lesion, elevation of the nasal ala and obliteration of the nasolabial fold. This report describes some clinical, radiological and morphological findings in a nasolabial cyst. The cyst was lined up with bilayered epithelium showing scattered goblet cells. The immunohistochemical analysis revealed that the basaloid epithelial cells exhibited nuclear positive reactions for p63. The proliferative activity of the epithelial cells was low (<5%). Reaction for podoplanin was only discretely positive in basal cells within the non-inflamed portions but was enhanced in areas with inflammatory changes of the cyst wall. Cytokeratin subtyping showed a distinct expression of intermediate filaments in the nasolabial cyst. Nasolabial cysts are developmental cysts that can be cured by adequate surgical techniques. The expression pattern of podoplanin in this entity points to an association of this protein expression with inflammatory reactions to the cyst.
KW - Adult
KW - Humans
KW - Female
KW - Tumor Markers, Biological/metabolism
KW - Membrane Glycoproteins/metabolism
KW - Transcription Factors/metabolism
KW - Cysts/metabolism/pathology/radiography/surgery
KW - Maxillary Neoplasms/metabolism/pathology/radiography/surgery
KW - Nasolabial Fold/pathology
KW - Tumor Suppressor Proteins/metabolism
KW - Adult
KW - Humans
KW - Female
KW - Tumor Markers, Biological/metabolism
KW - Membrane Glycoproteins/metabolism
KW - Transcription Factors/metabolism
KW - Cysts/metabolism/pathology/radiography/surgery
KW - Maxillary Neoplasms/metabolism/pathology/radiography/surgery
KW - Nasolabial Fold/pathology
KW - Tumor Suppressor Proteins/metabolism
M3 - SCORING: Journal article
C2 - 22523298
VL - 26
SP - 453
EP - 458
JO - IN VIVO
JF - IN VIVO
SN - 0258-851X
IS - 3
M1 - 3
ER -
