Myeloperoxidase: a leukocyte-derived protagonist of inflammation and cardiovascular disease
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Myeloperoxidase: a leukocyte-derived protagonist of inflammation and cardiovascular disease. / Nussbaum, Claudia; Klinke, Anna; Adam, Matti; Baldus, Stephan; Sperandio, Markus.
in: ANTIOXID REDOX SIGN, Jahrgang 18, Nr. 6, 20.02.2013, S. 692-713.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Myeloperoxidase: a leukocyte-derived protagonist of inflammation and cardiovascular disease
AU - Nussbaum, Claudia
AU - Klinke, Anna
AU - Adam, Matti
AU - Baldus, Stephan
AU - Sperandio, Markus
PY - 2013/2/20
Y1 - 2013/2/20
N2 - SIGNIFICANCE: The heme-enzyme myeloperoxidase (MPO) is one of the major neutrophil bactericidal proteins and is stored in large amounts inside azurophilic granules of neutrophils. Upon cell activation, MPO is released and extracellular MPO has been detected in a wide range of acute and chronic inflammatory conditions. Recent ADVANCES AND CRITICAL ISSUES: Apart from its role during infection, MPO has emerged as a critical modulator of inflammation throughout the last decade and is currently discussed in the initiation and propagation of cardiovascular diseases. MPO-derived oxidants (e.g., hypochlorous acid) interfere with various cell functions and contribute to tissue injury. Recent data also suggest that MPO itself exerts proinflammatory properties independent of its catalytic activity. Despite advances in unraveling the complex action of MPO and MPO-derived oxidants, further research is warranted to determine the precise nature and biological role of MPO in inflammation.FUTURE DIRECTIONS: The identification of MPO as a central player in inflammation renders this enzyme an attractive prognostic biomarker and a potential target for therapeutic interventions. A better understanding of the (patho-) physiology of MPO is essential for the development of successful treatment strategies in acute and chronic inflammatory diseases.
AB - SIGNIFICANCE: The heme-enzyme myeloperoxidase (MPO) is one of the major neutrophil bactericidal proteins and is stored in large amounts inside azurophilic granules of neutrophils. Upon cell activation, MPO is released and extracellular MPO has been detected in a wide range of acute and chronic inflammatory conditions. Recent ADVANCES AND CRITICAL ISSUES: Apart from its role during infection, MPO has emerged as a critical modulator of inflammation throughout the last decade and is currently discussed in the initiation and propagation of cardiovascular diseases. MPO-derived oxidants (e.g., hypochlorous acid) interfere with various cell functions and contribute to tissue injury. Recent data also suggest that MPO itself exerts proinflammatory properties independent of its catalytic activity. Despite advances in unraveling the complex action of MPO and MPO-derived oxidants, further research is warranted to determine the precise nature and biological role of MPO in inflammation.FUTURE DIRECTIONS: The identification of MPO as a central player in inflammation renders this enzyme an attractive prognostic biomarker and a potential target for therapeutic interventions. A better understanding of the (patho-) physiology of MPO is essential for the development of successful treatment strategies in acute and chronic inflammatory diseases.
KW - Cardiovascular Diseases/enzymology
KW - Humans
KW - Hypochlorous Acid/metabolism
KW - Infections/enzymology
KW - Inflammation/enzymology
KW - Leukocytes/enzymology
KW - Neutrophils/metabolism
KW - Peroxidase/metabolism
U2 - 10.1089/ars.2012.4783
DO - 10.1089/ars.2012.4783
M3 - SCORING: Review article
C2 - 22823200
VL - 18
SP - 692
EP - 713
JO - ANTIOXID REDOX SIGN
JF - ANTIOXID REDOX SIGN
SN - 1523-0864
IS - 6
ER -