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Mycalamide A shows cytotoxic properties and prevents EGF-induced neoplastic transformation through inhibition of nuclear factors

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Mycalamide A shows cytotoxic properties and prevents EGF-induced neoplastic transformation through inhibition of nuclear factors. / Dyshlovoy, Sergey A; Fedorov, Sergey N; Kalinovsky, Anatoly I; Shubina, Larisa K; Bokemeyer, Carsten; Stonik, Valentin A; Honecker, Friedemann.

in: MAR DRUGS, Jahrgang 10, Nr. 6, 06.2012, S. 1212-24.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Dyshlovoy, SA, Fedorov, SN, Kalinovsky, AI, Shubina, LK, Bokemeyer, C, Stonik, VA & Honecker, F 2012, 'Mycalamide A shows cytotoxic properties and prevents EGF-induced neoplastic transformation through inhibition of nuclear factors', MAR DRUGS, Jg. 10, Nr. 6, S. 1212-24. https://doi.org/10.3390/md10061212

APA

Dyshlovoy, S. A., Fedorov, S. N., Kalinovsky, A. I., Shubina, L. K., Bokemeyer, C., Stonik, V. A., & Honecker, F. (2012). Mycalamide A shows cytotoxic properties and prevents EGF-induced neoplastic transformation through inhibition of nuclear factors. MAR DRUGS, 10(6), 1212-24. https://doi.org/10.3390/md10061212

Vancouver

Dyshlovoy SA, Fedorov SN, Kalinovsky AI, Shubina LK, Bokemeyer C, Stonik VA et al. Mycalamide A shows cytotoxic properties and prevents EGF-induced neoplastic transformation through inhibition of nuclear factors. MAR DRUGS. 2012 Jun;10(6):1212-24. https://doi.org/10.3390/md10061212

Bibtex

@article{177c7ef60ef14c8fba69a7c65a506973,
title = "Mycalamide A shows cytotoxic properties and prevents EGF-induced neoplastic transformation through inhibition of nuclear factors",
abstract = "Mycalamide A, a marine natural compound previously isolated from sponges, is known as a protein synthesis inhibitor with potent antitumor activity. However, the ability of this compound to prevent malignant transformation of cells has never been examined before. Here, for the first time, we report the isolation of mycalamide A from ascidian Polysincraton sp. as well as investigation of its cancer preventive properties. In murine JB6 Cl41 P(+) cells, mycalamide A inhibited epidermal growth factor (EGF)-induced neoplastic transformation, and induced apoptosis at subnanomolar or nanomolar concentrations. The compound inhibited transcriptional activity of the oncogenic nuclear factors AP-1 and NF-κB, a potential mechanism of its cancer preventive properties. Induction of phosphorylation of the kinases MAPK p38, JNK, and ERK was also observed at high concentrations of mycalamide A. The drug shows promising potential for both cancer-prevention and cytotoxic therapy and should be further developed.",
keywords = "Animals, Apoptosis, Cell Line, Tumor, Cell Nucleus, Cell Transformation, Neoplastic, Epidermal Growth Factor, HeLa Cells, Humans, MAP Kinase Kinase 4, MAP Kinase Signaling System, Mice, NF-kappa B, Phosphorylation, Pyrans, Transcription Factor AP-1, Transcription, Genetic, Tumor Suppressor Protein p53, Urochordata, p38 Mitogen-Activated Protein Kinases, Journal Article, Research Support, Non-U.S. Gov't",
author = "Dyshlovoy, {Sergey A} and Fedorov, {Sergey N} and Kalinovsky, {Anatoly I} and Shubina, {Larisa K} and Carsten Bokemeyer and Stonik, {Valentin A} and Friedemann Honecker",
year = "2012",
month = jun,
doi = "10.3390/md10061212",
language = "English",
volume = "10",
pages = "1212--24",
journal = "MAR DRUGS",
issn = "1660-3397",
publisher = "MDPI AG",
number = "6",

}

RIS

TY - JOUR

T1 - Mycalamide A shows cytotoxic properties and prevents EGF-induced neoplastic transformation through inhibition of nuclear factors

AU - Dyshlovoy, Sergey A

AU - Fedorov, Sergey N

AU - Kalinovsky, Anatoly I

AU - Shubina, Larisa K

AU - Bokemeyer, Carsten

AU - Stonik, Valentin A

AU - Honecker, Friedemann

PY - 2012/6

Y1 - 2012/6

N2 - Mycalamide A, a marine natural compound previously isolated from sponges, is known as a protein synthesis inhibitor with potent antitumor activity. However, the ability of this compound to prevent malignant transformation of cells has never been examined before. Here, for the first time, we report the isolation of mycalamide A from ascidian Polysincraton sp. as well as investigation of its cancer preventive properties. In murine JB6 Cl41 P(+) cells, mycalamide A inhibited epidermal growth factor (EGF)-induced neoplastic transformation, and induced apoptosis at subnanomolar or nanomolar concentrations. The compound inhibited transcriptional activity of the oncogenic nuclear factors AP-1 and NF-κB, a potential mechanism of its cancer preventive properties. Induction of phosphorylation of the kinases MAPK p38, JNK, and ERK was also observed at high concentrations of mycalamide A. The drug shows promising potential for both cancer-prevention and cytotoxic therapy and should be further developed.

AB - Mycalamide A, a marine natural compound previously isolated from sponges, is known as a protein synthesis inhibitor with potent antitumor activity. However, the ability of this compound to prevent malignant transformation of cells has never been examined before. Here, for the first time, we report the isolation of mycalamide A from ascidian Polysincraton sp. as well as investigation of its cancer preventive properties. In murine JB6 Cl41 P(+) cells, mycalamide A inhibited epidermal growth factor (EGF)-induced neoplastic transformation, and induced apoptosis at subnanomolar or nanomolar concentrations. The compound inhibited transcriptional activity of the oncogenic nuclear factors AP-1 and NF-κB, a potential mechanism of its cancer preventive properties. Induction of phosphorylation of the kinases MAPK p38, JNK, and ERK was also observed at high concentrations of mycalamide A. The drug shows promising potential for both cancer-prevention and cytotoxic therapy and should be further developed.

KW - Animals

KW - Apoptosis

KW - Cell Line, Tumor

KW - Cell Nucleus

KW - Cell Transformation, Neoplastic

KW - Epidermal Growth Factor

KW - HeLa Cells

KW - Humans

KW - MAP Kinase Kinase 4

KW - MAP Kinase Signaling System

KW - Mice

KW - NF-kappa B

KW - Phosphorylation

KW - Pyrans

KW - Transcription Factor AP-1

KW - Transcription, Genetic

KW - Tumor Suppressor Protein p53

KW - Urochordata

KW - p38 Mitogen-Activated Protein Kinases

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.3390/md10061212

DO - 10.3390/md10061212

M3 - SCORING: Journal article

C2 - 22822368

VL - 10

SP - 1212

EP - 1224

JO - MAR DRUGS

JF - MAR DRUGS

SN - 1660-3397

IS - 6

ER -