PortalPublikationenMutational characterization of the bile acid receptor TGR5 i...

Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis.

  • Johannes R Hov
  • Verena Keitel
  • Jon K Laerdahl
  • Lina Spomer
  • Eva Ellinghaus
  • Abdou ElSharawy
  • Espen Melum
  • Kirsten M Boberg
  • Thomas Manke
  • Tobias Balschun
  • Christoph Schramm
  • Annika Bergquist
  • Tobias Weismüller
  • Daniel Gotthardt
  • Christian Rust
  • Liesbet Henckaerts
  • Clive M Onnie
  • Rinse K Weersma
  • Martina Sterneck
  • Andreas Teufel
  • Heiko Runz
  • Adolf Stiehl
  • Cyriel Y Ponsioen
  • Cisca Wijmenga
  • Morten H Vatn
  • Pieter C F Stokkers
  • Severine Vermeire
  • Christopher G Mathew
  • Benedicte A Lie
  • Ulrich Beuers
  • Michael P Manns
  • Stefan Schreiber
  • Erik Schrumpf
  • Dieter Häussinger
  • Andre Franke
  • Tom H Karlsen

Beteiligte Einrichtungen

Abstract

TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aimed to extensively investigate TGR5 sequence variation in PSC, as well as functionally characterize detected variants.

Bibliografische Daten

OriginalspracheDeutsch
Aufsatznummer8
ISSN1932-6203
DOIs
StatusVeröffentlicht - 2010
pubmed 20811628