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Mutagenicity testing of imidazole and related compounds.

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Mutagenicity testing of imidazole and related compounds. / Forster, R; Blowers, S D; Cinelli, S; Marquardt, H; Westendorf, Johannes.

in: MUTAT RES-FUND MOL M, Jahrgang 298, Nr. 2, 2, 1992, S. 71-79.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Forster, R, Blowers, SD, Cinelli, S, Marquardt, H & Westendorf, J 1992, 'Mutagenicity testing of imidazole and related compounds.', MUTAT RES-FUND MOL M, Jg. 298, Nr. 2, 2, S. 71-79. <http://www.ncbi.nlm.nih.gov/pubmed/1282214?dopt=Citation>

APA

Forster, R., Blowers, S. D., Cinelli, S., Marquardt, H., & Westendorf, J. (1992). Mutagenicity testing of imidazole and related compounds. MUTAT RES-FUND MOL M, 298(2), 71-79. [2]. http://www.ncbi.nlm.nih.gov/pubmed/1282214?dopt=Citation

Vancouver

Forster R, Blowers SD, Cinelli S, Marquardt H, Westendorf J. Mutagenicity testing of imidazole and related compounds. MUTAT RES-FUND MOL M. 1992;298(2):71-79. 2.

Bibtex

@article{42d2c67686a14acabd55a1f28e6b6718,
title = "Mutagenicity testing of imidazole and related compounds.",
abstract = "Ames tests have been performed with imidazole and its principal metabolites, hydantoin and hydantoic acid. N-Acetyl-imidazole, a potential metabolite resulting from the action of intestinal bacteria, and histamine, a structurally related compound which is widely distributed in mammalian tissues, have also been tested. Imidazole and histamine were also tested in the UDS assay in primary rat hepatocytes, while imidazole alone was tested in the M2-C3H mouse fibroblast malignant transformation assay. Imidazole gave consistently negative results in the Ames test, the UDS assay and the transformation assay. The three metabolites of imidazole, namely hydantoin, hydantoic acid and N-acetyl-imidazole, all gave negative results in the Ames test. Histamine gave no evidence of mutagenic activity in the Ames test or of genotoxicity in the UDS assay. These results indicate that imidazole and its metabolites are unlikely to present a mutagenic or carcinogenic hazard.",
author = "R Forster and Blowers, {S D} and S Cinelli and H Marquardt and Johannes Westendorf",
year = "1992",
language = "Deutsch",
volume = "298",
pages = "71--79",
number = "2",

}

RIS

TY - JOUR

T1 - Mutagenicity testing of imidazole and related compounds.

AU - Forster, R

AU - Blowers, S D

AU - Cinelli, S

AU - Marquardt, H

AU - Westendorf, Johannes

PY - 1992

Y1 - 1992

N2 - Ames tests have been performed with imidazole and its principal metabolites, hydantoin and hydantoic acid. N-Acetyl-imidazole, a potential metabolite resulting from the action of intestinal bacteria, and histamine, a structurally related compound which is widely distributed in mammalian tissues, have also been tested. Imidazole and histamine were also tested in the UDS assay in primary rat hepatocytes, while imidazole alone was tested in the M2-C3H mouse fibroblast malignant transformation assay. Imidazole gave consistently negative results in the Ames test, the UDS assay and the transformation assay. The three metabolites of imidazole, namely hydantoin, hydantoic acid and N-acetyl-imidazole, all gave negative results in the Ames test. Histamine gave no evidence of mutagenic activity in the Ames test or of genotoxicity in the UDS assay. These results indicate that imidazole and its metabolites are unlikely to present a mutagenic or carcinogenic hazard.

AB - Ames tests have been performed with imidazole and its principal metabolites, hydantoin and hydantoic acid. N-Acetyl-imidazole, a potential metabolite resulting from the action of intestinal bacteria, and histamine, a structurally related compound which is widely distributed in mammalian tissues, have also been tested. Imidazole and histamine were also tested in the UDS assay in primary rat hepatocytes, while imidazole alone was tested in the M2-C3H mouse fibroblast malignant transformation assay. Imidazole gave consistently negative results in the Ames test, the UDS assay and the transformation assay. The three metabolites of imidazole, namely hydantoin, hydantoic acid and N-acetyl-imidazole, all gave negative results in the Ames test. Histamine gave no evidence of mutagenic activity in the Ames test or of genotoxicity in the UDS assay. These results indicate that imidazole and its metabolites are unlikely to present a mutagenic or carcinogenic hazard.

M3 - SCORING: Zeitschriftenaufsatz

VL - 298

SP - 71

EP - 79

IS - 2

M1 - 2

ER -